SNPMiner Trials by Shray Alag


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Report for Mutation M11T

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Consecutive, Case Control Study of Association Between Single Nucleotide Polymorphism of SP-D and Susceptibility and Prognosis of Infectious Keratitis

This study explores the association between single nucleotide polymorphism (Met11Thr) of surfactant protein D(SP-D) and susceptibility and prognosis of infectious keratitis.Met11Thr of SP-D of patients with keratitis and normal controls were compared.Allele and genotype frequencies of patients with keratitis and normal controls were determined by polymerase chain reaction with sequence specific primers(PCR-SSPs) .SP-D gene polymorphism of patients with keratitis and normal controls was detected by Sanger sequencing

NCT04213313 Infectious Keratitis Drug: Treatment of bacterial keratitis Drug: Treatment of fungal keratitis Drug: Treatment of viral keratitis Diagnostic Test: corneal scraping Other: Sequencing
MeSH: Communicable Diseases Infection Keratitis
HPO: Keratitis

Association Between SNP of SP-D and Susceptibility and Prognosis of Infectious Keratitis This study explores the association between single nucleotide polymorphism (Met11Thr) of surfactant protein D(SP-D) and susceptibility and prognosis of infectious keratitis.Met11Thr of SP-D of patients with keratitis and normal controls were compared.Allele and genotype frequencies of patients with keratitis and normal controls were determined by polymerase chain reaction with sequence specific primers(PCR-SSPs) .SP-D gene polymorphism of patients with keratitis and normal controls was detected by Sanger sequencing Base type. --- Met11Thr ---

Primary Outcomes

Description: Base type of SNP(rs721917):(Met and Thr)

Measure: Base type

Time: before the treatment

Description: Genotype of SNP(rs721917):( Met /Met , Thr/Thr and Met/Thr)

Measure: Genotype

Time: before the treatment

Secondary Outcomes

Description: Grading of Keratitis: cornea:transparency ,edema,turbidity,perforation conjunctiva: hyperaemia blephar:inflammation

Measure: Grading of Keratitis

Time: before the treatment


HPO Nodes


Keratitis
Genes 85
COL7A1 NIPAL4 GJB6 HLA-DRB1 TLR4 GTF2H5 ERCC6 TGM1 STAT4 CCR1 ERCC2 ERCC5 FGFR2 IARS2 XPA TP63 MBTPS2 GJB2 ERCC2 NLRP3 MPLKIP TARS1 BTD XPC ABCA12 ERCC2 ERCC2 LMNA ALOX12B ERAP1 WIPF1 B2M GTF2E2 ZEB1 HLCS LBR KLRC4 ZMPSTE24 IKBKG IL10 NTRK1 GSN XPA UBAC2 HLA-B PLG PLEC POLH C4A FOXE3 IL12A-AS1 MBTPS2 IL12A IL23R DDB2 MPLKIP NOD2 BTNL2 NLRP1 UROS MEFV DDB2 RNF113A PNPLA1 ERCC3 RNF125 MAB21L1 ERCC4 CRLF1 GATA1 SCN9A NOD2 GJB2 MBTPS2 XPC ERCC3 CERS3 PAX6 GJB2 FAS AIRE IKBKG WAS POLH ALOXE3