SNPMiner Trials (Home Page)
Report for Mutation V57I
 Developed by Shray Alag, 2020.
SNP Clinical Trial Gene 
There are 2 clinical trials
Clinical Trials
      This phase II trial is studying the side effects of and how well alisertib works in treating
      young patients with relapsed or refractory solid tumors or leukemia. Alisertib may stop the
      growth of cancer cells by blocking some of the enzymes needed for cell growth.
    
To explore the relationship between polymorphic variations in the
      UDP-glucuronosyltransferase gene UGT1A1 and exposure to MLN8237, and to assess 2 common
      polymorphic variants in the aurora A kinase gene, Phe31Ile and Val57Ile. --- Phe31Ile ---  --- Val57Ile --- 
  Primary Outcomes 
 Description: For patients with recurrent solid tumors a patient who experienced a complete or partial response according to RECIST version 1.1 criteria is considered a responder. For patients with recurrent acute lymphoblastic leukemia a patient who experiences a bone marrow evaluation with < 5% blast cells on morphological evaluation of bone marrow will be considered a responder. For patients with recurrent acute myelogenous leukemia a patient who experiences a complete remission or complete remission with partial recovery of platelet count according to the AML International Working Group Criteria will be considered a responder.
 Measure: Number of Participants With Overall Response
 Time: From first dose of alisertib through 6 cycles of protocol therapy or until removal from protocol therapy whichever occurred first.
  Secondary Outcomes 
 Description: The number of patient-cycles in which the adverse event considered grade 3 or higher AE according to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 considered by the treating physician to be possibly, probably or definitely related to alisertib.
 Measure: Number of Patients Cycles With Grade 3 or Higher Adverse Event
 Time: Up to 24 months
 Description: Serum concentration of alisertib prior to the first day of administration in nanograms/milliliter.
 Measure: Serum Concentration of Alisertib Prior to the First Day of Administration
 Time: day 1 of protocol therapy
 Description: Serum concentration of alisertib on the first day of administration one hour after administration in nanograms/milliliter.
 Measure: Serum Concentration of Alisertib on the First Day of Administration One Hour After Administration
 Time: day 1 of protocol therapy
 Description: Serum concentration of alisertib on the first day of administration three hours after administration in nanograms/milliliter.
 Measure: Serum Concentration of Alisertib on the First Day of Administration Three Hours After Administration
 Time: day 1 of protocol therapy
 Description: Serum concentration of alisertib on the first day of administration six hours after administration in nanograms/milliliter.
 Measure: Serum Concentration of Alisertib on the First Day of Administration Six Hours After Administration
 Time: day 1 of protocol therapy
 Description: Serum concentration of alisertib on the fourth day of administration prior to the administration of the day 4 dose in nanograms/milliliter.
 Measure: Serum Concentration of Alisertib on the Fourth Day of Administration Prior to the Administration of the Day 4 Dose
 Time: day 4 of protocol therapy
 Description: Serum concentration of alisertib on the seventh day of administration prior to the administration of the day 7 dose in nanograms/milliliter.
 Measure: Serum Concentration of Alisertib on the Seventh Day of Administration Prior to the Administration of the Day 7 Dose.
 Time: day 7 of protocol therapy
2 A Phase I/II Study of MLN8237, an Oral Selective Small Molecule Inhibitor of Aurora A Kinase, in Children With Relapsed/Refractory Solid Tumors 
      RATIONALE: MLN8237 may stop the growth of cancer cells by blocking some of the enzymes needed
      for cell growth.
      PURPOSE: This phase I/II trial is studying the side effects and best dose of MLN8237 and to
      see how well it works in treating young patients with relapsed or refractory solid tumors
    
NCT02444884  Unspecified Childhood Solid Tumor, Excluding CNS  Neuroblastoma  Drug: MLN8237 MeSH: Neuroblastoma   
HPO: Neuroblastoma   
To assess two common polymorphic variants in the Aurora A kinase gene (Phe31Ile and
      Val57Ile) thought to potentially influence tumorigenesis. --- Phe31Ile ---  --- Val57Ile --- 
  Primary Outcomes 
 Measure: Determine maximum tolerated dose and RP2D administered once daily on Days 1-7
 Time: Up to 21 days (1st cycle) of protocol therapy
 Measure: Determine maximum tolerated dose and RP2D administered po BID on Days 1-7
 Time: Up to 21 days (1st cycle) of protocol therapy
 Description: DLT will be defined as possibly, probably or definitely attributable to MLN8237. The DLT observation period for the purposes of dose-escalation will be the first cycle of therapy
 Measure: Adverse events as assessed by (CTCAE) version 4.0
 Time: Every 21 days (each cycle) of protocol therapy for up to 35 cycles [up to 105 weeks]
 Description: single-dose AUC, trough estimation, t½ of accumulation
 Measure: PK Profile: MLN8237 concentrations in plasma samples
 Time: 30 min after the first dose, and at 1,2, 3, 4, 6-8, 24 hours, Day 4 and 7 in Cycle 1
HPO Nodes
Neuroblastoma 
Genes 53
TUBB  GPC4  BDNF  NUTM1  PHOX2B  MLH1  PMS2  RET  MSH6  PRDM16  PHOX2B  RERE  SDHB  MSH6  PHOX2B  NF1  EPCAM  KIF1B  EDN3  TUBB  TGFBR2  SEMA4A  ASCL1  RET  FAN1  GABRD  ASCL1  RAF1  RUNX1  GDNF  GDNF  BRAF  BMPR1A  KRAS  BRD4  MLH1  MSH2  PMS2  MLH3  GPC3  PTPN11  MYO1H  PIK3CA  PHOX2B  KCNAB2  MAPRE2  RPS20  PHOX2B  PMS1  EDN3  PALB2  MSH2  SKI   hr>
Renal neoplasm 
Genes 167
GPC3  REST  GPC3  TSC2  VAMP7  TRIP13  HNF1B  BUB1B  KCNQ1OT1  SOX9  FLCN  SDHC  TRIM37  SDHAF2  LMNA  EXT2  GATA4  TSC2  BRCA2  SRC  BUB1  FH  APC  SLC49A4  SDHB  WT1  HDAC4  SLC25A11  SDHD  BAP1  ALX4  SRY  VHL  KLLN  CTNNB1  NR5A1  KEAP1  DICER1  DIS3L2  WT1  FIBP  DLC1  FN1  PIK3CA  NOD2  SDHC  FGFR3  VHL  MAP3K1  EP300  FOXE1  WT1  AXIN2  MITF  PAX6  SDHD  IFNG  NSD1  TBX18  H19  H19  TRIM28  MDH2  PTCH1  GPC4  MLH1  POU6F2  AKT1  WT1  CCND1  ZFPM2  H19-ICR  TP53  TRIP13  GPC4  COL14A1  TRIM28  VHL  WT1  MET  TSC1  TRIP13  AKT1  MSH6  POU6F2  HABP2  CDC73  H19  KCNQ1OT1  H19  IGF2  NRAS  BUB1B  KCNQ1  FLCN  CDKN1B  DIS3L2  CDC73  REST  PRCC  IGF2  CDKN1B  STK11  WT1  WT1  NR0B1  BUB3  DCC  WT1  TSC1  KLLN  MSH2  HNF1B  TSC2  TP53  SEC23B  GPC3  PTEN  HNF1A  KIF1B  MAX  DICER1  PIK3CA  PIK3CA  DIS3L2  RNF139  MINPP1  DMRT3  BRCA2  BUB1  RET  CDKN1C  AAGAB  TSC1  WT1  FH  GPC3  WRN  PIK3CA  TMEM127  VHL  IGF2  FLCN  H19  OGG1  SETBP1  SDHB  BUB1B  SDHA  IGF2  CEP57  TFE3  FH  CDC73  GPC4  DICER1  PTPRJ  LMNA  HNF4A  DLST  H19  SDHB  BMPER  PALB2  FLCN  PHF21A  WWOX   hr>
Peripheral primitive neuroectodermal neoplasm 
Genes 54
TUBB  GPC4  BDNF  NUTM1  PHOX2B  MLH1  PMS2  RET  MSH6  PRDM16  PHOX2B  RERE  SDHB  MSH6  PHOX2B  NF1  EPCAM  KIF1B  EDN3  TUBB  TGFBR2  SEMA4A  ASCL1  RET  FAN1  GABRD  ASCL1  RAF1  RUNX1  GDNF  GDNF  BRAF  BMPR1A  KRAS  BRD4  MLH1  MSH2  PMS2  MLH3  GPC3  PTPN11  MYO1H  PIK3CA  PHOX2B  KCNAB2  MAPRE2  RPS20  PHOX2B  FLI1  PMS1  EDN3  PALB2  MSH2  SKI   hr>
Ependymoblastoma 
 hr>
Sarcoma 
Genes 197
REST  RB1  SDHC  KRAS  PAX7  ABCA5  ASPSCR1  RECQL4  SUFU  APC  ANTXR2  FH  GREM1  KRT17  EXT1  PIK3CA  BMPR1B  RASGRP1  KIT  SDHD  PRKCD  REST  KCNN3  IDH2  NF1  CTNNB1  PDGFRB  CDKN2B  KEAP1  DICER1  DICER1  TAF15  CDKN2A  FGFR3  SLC22A18  PTCH2  CDKN2C  NBN  CHEK2  EP300  AXIN2  CHEK2  IFNG  PTH1R  COL1A1  FOXO1  TBX18  GJC2  FLT4  PRKAR1A  DHCR24  MSH2  MLH1  ANTXR2  GNAS  CASP10  TRIP13  NUTM1  MDM2  TSC1  PTEN  KCNH1  BUB1B  FLNA  NF2  ELMO2  NF1  BUB3  DCC  MEN1  TSC1  MSH2  TP53  PTEN  FAM20C  PDGFB  BUB1  NOTCH3  ATP6V1B2  TSC1  SUFU  FLCN  WT1  MSH2  MEN1  FH  NRAS  MTAP  APC  NF1  CHEK2  NR4A3  NBN  APC  NF2  TSC2  IL6  SPRED1  AKT1  NRAS  BUB1B  SOS1  FLCN  SDHC  SMARCB1  IDH1  LMNA  MSH6  SDHC  TSC2  NF2  SRC  BUB1  APC  RECQL4  ABCA5  SDHB  GNAS  APC  PDGFRB  VEGFC  HRAS  KCNH1  FAS  BRD4  PRLR  DLC1  SDHB  PIK3CA  WRN  TP53  MAP2K1  IDH1  BRAF  MLH1  CDKN1A  RPS19  FOXC2  EWSR1  PTCH1  APC  AKT1  CDKN2A  KIT  TP53  PDGFB  AKT1  MSH6  EWSR1  CDC73  KIT  NRAS  IDH2  EXT2  CDKN1B  SOS1  NF1  KLLN  APC  TSC2  SSX2  SEC23B  DICER1  PIK3CA  PDGFRA  FAS  EXT1  APC  RECQL4  HRAS  MLH1  CTNNB1  BMPR1A  PMS2  EXT2  WRN  PTEN  SSX1  SDHA  PTPN11  SDHB  BUB1B  PAX3  FASLG  GDF5  CEP57  SQSTM1  CDC73  EXT1  TP53  PTPRJ  CDKN1B  PLCD1  RB1  APC  PTCH1  MC1R   hr>
Leukemia 
Genes 190
ATM  KRAS  KIT  RPS15A  NF1  MPL  RPL35A  RPL11  RPL18  DDX41  SBDS  LPP  ETV6  BUB1B  F13A1  DNMT3A  JAK2  NUP214  FANCD2  MSH6  FANCA  PIGL  NRAS  TCIRG1  BUB1  TET2  FLT3  TAL1  ATRX  TREX1  PDGFRA  SRP54  RPS29  PTPN11  CALR  FANCE  WIPF1  SF3B1  GATA2  GLI1  STS  SH3GL1  XRCC4  MPL  SH2B3  EFL1  PIGA  TREM2  CBL  MPL  RUNX1  MPL  PIGL  THPO  FANCG  NSD1  BRD4  NSUN2  SH2B3  RARA  GATA2  NPM1  CBL  CHIC2  ERBB3  GFI1  TERT  KIT  BCR  ARHGAP26  DYNC2LI1  EVC  SCN10A  GATA1  ELANE  RNASEH2B  RPS14  SH2B3  JAK2  RPL15  SBDS  NRAS  RPL26  RPL27  ADA2  RPS7  TYROBP  F13B  MSH2  BCR  WAS  TERC  TP53  TRIP13  MYD88  NUTM1  RPS24  GNB1  TP53  DNMT3A  TERT  NUMA1  NUP214  RPL5  SAMD9L  TET2  CFTR  POT1  FANCC  RPS10  EP300  EVC2  BUB1B  CEBPA  BRCA2  DNAJC21  CALR  SCN9A  LIG4  ADAR  BLM  TET2  JAK2  SMPD1  RNASEH2C  SCN11A  GATA2  BUB3  PRSS1  KIF11  BCR  RPL35  TAL2  SRP54  IFIH1  ABL1  PDGFRB  KRAS  RNASEH2A  TET2  MLLT10  SRP54  DNAJC21  DKC1  RUNX1  APC  LIG4  CBFB  BLM  THPO  CALR  NBN  JAK2  MLH1  RPS19  ELANE  SAMD9L  RPL31  PMS2  ASXL1  TSR2  MLF1  PIK3CA  DNAJC21  RUNX1  GFI1  SRSF2  SETBP1  HAX1  RPS26  RPS17  FLT3  RPS27  PIK3R1  KRAS  CEP57  PICALM  CREBBP  GATA2  CTRC  MYD88  TET2  RPS28  ABL1  RB1  SPINK1  GATA1  NBN  JAK2  SAMHD1   hr>
Ewing sarcoma 
Genes 4
EWSR1  RB1  NUTM1  BRD4   hr>
Rhabdomyosarcoma 
Genes 25
TRIP13  KEAP1  DICER1  PAX7  HRAS  DICER1  MLH1  NRAS  BUB1B  PMS2  SLC22A18  MSH6  NBN  BUB1B  BUB1  PAX3  CEP57  FOXO1  BUB3  PTCH1  NF1  MSH2  DICER1  NBN  MC1R   hr>
Osteosarcoma 
Genes 17
RECQL4  TP53  RB1  RECQL4  CHEK2  SQSTM1  MDM2  TP53  RPS19  WRN  CDKN2A  MTAP  RECQL4  TP53  RB1  LMNA  CHEK2   hr>
Neuroectodermal neoplasm 
Genes 94
TUBB  TSC2  RB1  GPC4  BDNF  NUTM1  GLI3  BRCA2  PHOX2B  TSC1  LRP5  MLH1  PMS2  APC  IDH1  RET  MSH6  POT1  PRDM16  TSC2  PHOX2B  CDKN2A  RERE  NF2  MSH3  SDHB  MSH6  PHOX2B  APC  NF1  EPCAM  TSC1  KIF1B  EDN3  TUBB  TGFBR2  SEMA4A  ASCL1  IDH1  IDH2  RET  FAN1  GABRD  ASCL1  RAF1  RUNX1  GDNF  APC  GDNF  MSH3  BRAF  BMPR1A  KRAS  BRD4  KEAP1  DICER1  MLH1  MSH2  C11ORF95  PMS2  MLH3  GPC3  TP53  PTPN11  MYO1H  PIK3CA  NBN  RELA  CHEK2  SETBP1  PHOX2B  KCNAB2  IGF2  MAPRE2  IFNG  RB1  RPS20  PHOX2B  H19  FLI1  NF1  PMS1  RB1  CHEK2  EDN3  PALB2  APC  TP53  MSH2  SKI  NBN  ERBB2  APC  NF2   hr>
Embryonal rhabdomyosarcoma 
Genes 2
SLC22A18  DICER1   hr>
Hepatoblastoma 
Genes 18
TTC37  SETBP1  SETBP1  APC  H19-ICR  SKIV2L  GPC4  CDKN1C  APC  APC  GPC3  APC  KCNQ1OT1  H19  APC  IGF2  SLC37A4  KCNQ1   hr>
Neoplasm 
Genes 1473
GPC3  LETM1  LZTS1  REST  MPL  ARID1B  RPL18  MGMT  GLI3  BIRC3  ZSWIM6  TRNS2  ETV6  HNF1B  KIT  BRCA1  SUFU  PLAG1  SOX9  TP63  CTSC  RASA1  ATRX  TRIM37  SUFU  BTK  CYP11B1  NOTCH3  EPCAM  PORCN  PIGL  AR  TET2  FH  TGIF1  HMBS  ATRX  TREX1  SMAD4  KRT17  FGFR1  WDPCP  SF3B1  GPR101  KIT  GLI1  SLC25A11  XRCC4  SDHD  PRKCD  RNF43  SDHB  BAP1  EGFR  PIGA  NF1  ASCL1  MPL  RET  C2CD3  GDNF  NR5A1  DICER1  TNFRSF4  CASP10  TERC  FGF8  PSAP  CIB1  SLC22A18  PTCH2  ENPP1  CDKN2C  SLC25A11  GPR101  KIT  AXIN2  TREX1  DYNC2LI1  ERCC4  RPS14  COMP  TINF2  FOXE1  DHCR24  RPS7  TYROBP  HOXD13  ERBB2  BLK  EYA1  ZFPM2  ERCC6  NLRP1  STAC3  ERCC5  NUTM1  MEN1  WT1  BCL10  GNPTAB  KRAS  TP53  KDR  PUF60  TRNF  FCN3  SDHC  KCNH1  MSTO1  EP300  BUB1B  GNA11  KCNE3  DOCK8  SEMA3C  ACD  GLI2  SMPD1  SUFU  NF1  PTCH2  ACAN  DCC  WT1  CTSA  KIF11  BCR  SRGAP1  KIT  PTEN  LEMD3  MLLT10  SCN4A  BRCA2  BMPR1A  NOTCH3  SEC23A  CDKN1C  BARD1  SPIB  RSPO1  MC2R  CALR  ATP6V1B2  NBN  RAD54L  MST1  SUFU  MYCN  TMEM127  SRD5A3  IGF2  CD28  RUNX1  OGG1  HAX1  SDHC  CTNNB1  MST1R  SDHA  IGF2  KCNJ10  IL12RB1  MEN1  RAD51  TFE3  ND5  MMEL1  MVK  APC  FLI1  RNF6  NF1  BRCA2  SUFU  GPC6  NR4A3  TTC37  KIT  NRTN  BLNK  IGH  SPRED1  TXNRD2  IGF2R  FOXP1  BUB1B  SOS1  LRP5  GJB2  DNMT3A  PMS2  PRKN  RET  MSH6  ACVRL1  MPLKIP  ERCC2  AIP  GNAS  TAL1  NNT  RECQL4  PMS1  DLL1  EIF2AK4  STAT6  MNX1  SDHB  KRAS  MEN1  MN1  SH2B3  EFL1  VHL  KLLN  RMRP  RUNX1  SIX3  GDNF  FANCD2  EXT1  CDH23  BRD4  DLEC1  NODAL  CARMIL2  SDHB  MSH2  HMBS  SMAD4  SRP72  NRAS  DOCK8  SPRTN  BRCA1  MAP2K1  KRT14  LETM1  TERT  MAP2K2  HRAS  WHCR  WT1  IDH1  TMEM107  SCN10A  GJB3  SDHD  KRAS  GATA1  RPS20  GJB2  SLX4  USP8  PRKAR1A  CR2  JAK2  HFE  MPL  POT1  BRCA2  GNAI3  SDHB  ALK  OCA2  TP53  GPC4  ACTG2  CTNNB1  HSPG2  AR  FGFR1  STK4  MET  TMC8  MRAP  MSH6  CCBE1  EWSR1  LMO1  EDN3  LEMD3  PGM3  FGFR3  CASP8  RB1CC1  SCN9A  FANCL  TG  SDHD  COX3  IGF2  COL11A2  AGGF1  GPR101  PRKN  PLCB4  SDHD  NF1  GTF2E2  MAP2K1  ESCO2  CDC73  WRAP53  TET2  PDGFRB  RNASEH2A  RAD21  HNF1A  TGFBR2  POLD1  COX2  TNFRSF10B  MINPP1  DNAJC21  FAS  EXT1  SLC26A2  APC  SDHAF2  TINF2  LIG4  POLR1D  WWOX  TMC6  RPS19  ERCC2  SASH1  MC1R  MVD  SEC23B  CYP2A6  GPC3  KIT  HRAS  RAD54L  SDHA  GDNF  NKX2-1  GFI1  ALX3  STAT3  MYH11  DYNC2LI1  FGFR2  TCOF1  PTEN  MAFA  PIK3R1  SLC25A13  HRAS  VHL  COL7A1  GNAS  FGFR2  PIK3CA  GPC4  DICER1  ERCC3  PIK3CA  RAD51C  RB1  RMRP  MLH3  ATM  COL7A1  LIG4  NF1  VAMP7  RPL35A  RB1  SETD2  BCL10  LPP  NRAS  KRAS  ABCA5  ERCC2  PDE6D  KCNQ1OT1  MS4A1  SLC22A18  APC  LIG4  JAK2  FANCD2  GAS1  STAG3  NRAS  PALLD  SLC22A18  RFWD3  PPP2R1B  APC  PTPN11  PTEN  WIPF1  PIK3CA  NOP10  IL7  UROD  TNFRSF1B  TP53  REST  SLC37A4  NHP2  CXCR4  KIT  CYSLTR2  FZD2  ALX4  BMPR1A  SRY  TRNQ  SDHD  PIGL  CCM2  FIBP  FANCI  GJB4  SPINK1  RPL10  NSD2  MAP3K1  RET  CDK4  HSPA9  TET2  GFI1B  MAD2L2  DCC  AP2S1  SMAD7  BRCA2  TRNK  ERCC3  BRCA1  ELANE  SFTPC  PTH1R  COL1A1  FUZ  OFD1  RET  FLT4  PRKAR1A  SBDS  RPL26  SMARCE1  SMARCAD1  MSH2  BCR  GPR35  INTU  FANCA  STAT1  ANTXR2  FGFRL1  TUBB  BRAF  SLX4  CASP10  TERT  RAD21  MTOR  TRIP13  MYD88  DPM1  RSPO1  PTPN11  CTNNB1  AIP  PTEN  VANGL1  CYP2D6  RPS10  GCK  KRT16  DNAJC21  BCL2  AKT1  KRAS  KLF6  NOTCH1  FLNA  MAX  NF2  PALB2  TP53  PSENEN  RNF6  TSC1  HNF1B  TP53  RFWD3  SDHD  PERP  TP53  DIS3L2  B3GALT6  STS  PDGFB  SMARCB1  BRAF  BRIP1  CBFB  BUB1  BLM  INHBA  CALR  NBN  MLH3  TAF1  MLF1  PIK3CA  MSH2  CTLA4  ND6  PALB2  WT1  PTCH1  POLE  ADA  MC1R  FLT4  ATP7A  MLH3  SMO  TRNF  NRAS  LMNA  DLST  TRNL1  MTAP  TP53  ZAP70  SDHB  CHEK2  PALB2  FLT4  CDK4  NBN  MSR1  CC2D2A  TNPO3  ECE1  RPS15A  NAGS  TMEM67  HNF1A  PIK3CA  ATP7A  AKT1  NRAS  SDHAF2  CXCR4  TSC2  NF2  EPHB2  WDPCP  OFD1  BUB1  FLT3  APC  SMARCA4  CDKN2A  RPS29  MCM4  PDGFRA  ESCO2  CTC1  ESR1  SDHB  MSH6  APC  HABP2  GNAQ  KIF1B  SH3GL1  CD70  MPL  IGH  ZIC2  GCM2  VEGFC  HRAS  CTNNB1  KCNH1  LRRC8A  BRAF  FAS  ICOS  NSD1  RNF43  AKT1  BIN1  DLC1  SH2B3  RARA  WNT10A  CARD14  SDHC  EXOC6B  ESCO2  POLR1C  G6PC  MSH6  KRT1  PDX1  TNFRSF13C  ERCC3  EVC  SNAI2  CD79A  BRCA1  RNASEH2B  CCND1  TP53  RPS19  H19  H19  BRCA2  TFAP2A  ARMC5  FASLG  FGFR3  APC  F5  EDN1  MAP3K8  AIP  APC  AKT1  TERC  CCND1  CEL  MYC  TP53  GPC4  ERCC5  HNF1A  POLE  DAXX  NUP214  TRIP13  AKT1  TET2  CDC73  ND1  MUTYH  PIK3R1  TERT  CEBPA  EXT2  OCRL  DIS3L2  ADAR  TGFBR2  BRCA2  MRE11  SOS1  HNF4A  FAH  TMEM127  WT1  AXIN2  TCF4  EDN3  PTPN3  KRAS  SEMA4A  PIK3CA  XPA  MFN2  TINF2  PIK3CA  APPL1  RUNX1  GNPTAB  FGFR3  NRAS  PDCD10  RAG2  PTEN  CTNNB1  SOX2  BMPR1A  HBB  TERT  USP9X  NFKB1  FANCC  PRF1  WRN  SRY  SRSF2  PMS2  RHBDF2  PHOX2B  RPS17  PAX3  RECQL4  KIF1B  SQSTM1  RB1  EXT1  XPC  CYLD  TOP2A  MYD88  CDKN1B  TET2  GJB2  PTEN  UBE2T  RTEL1  PTCH1  KLHDC8B  GATA1  POLH  JAK2  RHOH  FLCN  DCLRE1C  MTMR14  GTF2H5  PTEN  SBDS  TBC1D24  PAX7  AR  TP53  ASPSCR1  MTM1  RECQL4  ERCC2  TGFBR2  ERCC4  JAK2  SF3B1  CDKN2B  XPC  GATA4  KIT  POU2AF1  BRCA2  GREM1  CDON  NTHL1  DICER1  GINS1  ATM  RAD51D  SHOX  EXT1  RASGRP1  WT1  GATA2  NF2  ERCC4  TUBB  MBTPS2  DHCR7  MYLK  KCNN3  TCTN3  TMEM216  TMEM231  KRT1  CTNNB1  MPL  PDGFRB  FANCG  RPGRIP1L  KEAP1  DICER1  WT1  BAP1  FOXI1  ERCC4  CDKN2A  FGFR3  KDSR  CBL  HRAS  BMPR1A  DISP1  RELA  MAP3K1  PARN  BCR  ENG  COL7A1  LMOD1  KRAS  PAX6  SNAI2  GLI3  FANCF  FOXO1  RPL15  TBX18  TRPV3  PIK3CA  NRAS  CDH1  GNAS  SMARCB1  KLF11  ADA2  EDN3  POU6F2  CDH1  GNAS  IL1B  SMAD4  H19-ICR  SDHB  STK11  NF2  TRIM28  SEC23A  SLCO2A1  BRCA2  BRAF  DNMT3A  MDM2  BMP2  BRCA2  DHH  NRAS  POU6F2  CTBP1  PTCH2  FLCN  CALR  BAP1  LIG4  HRAS  REST  BRAF  SAMD9  NDP  TYR  KRT17  MUC5B  PRSS1  MEN1  NPM1  ITK  MSH2  CYLD  TAL2  SRP54  IFIH1  HMMR  TCTN3  ND5  JAK2  FAM20C  RET  NEK9  DMRT3  KRAS  MINPP1  SH3KBP1  THPO  FAH  KRT5  JAK2  PHKG2  TSC1  TNFRSF13C  MEN1  FH  RPL31  FANCG  PIK3CA  IL2RG  DNAJC21  VANGL2  MYO1H  ALX1  CDKN2A  AIP  H19  NRAS  TWIST1  PTEN  TRNK  TRPS1  RPS26  MAPRE2  RPS27  TCF3  KRT17  ERCC6  DHH  MMP1  FGFR1  SEMA3D  PTCH1  ABL1  CDKN2A  SKI  APC  WWOX  ZSWIM6  NF2  WNT10A  KRAS  GPC3  REST  GJB6  HRAS  VHL  CTNNB1  TGFBR1  IL6  TDGF1  RPL11  IL1RN  BRCA1  MGAT2  POT1  ASCC1  XPA  TBX2  FLCN  HFE  NTHL1  SMARCB1  DVL3  TRNH  IDH1  FANCA  LAMB3  CD79B  RAD51C  PRDM16  PHOX2B  GNAQ  CCL2  PDGFRA  CREB1  SRP54  PIEZO2  TRNL1  GBA  GNAS  WNT5A  PIK3CA  STS  FANCB  KRAS  MAGT1  RAD51  IDH1  TNFRSF13B  TREM2  GABRD  BCL10  SKIV2L  POLD1  KRIT1  KRAS  ARSA  SMAD4  RAD51  TP53  DIS3L2  KIAA0753  PRLR  CD96  LZTR1  WRN  GATA2  EDNRB  MUTYH  ATM  CHIC2  TP53  CYLD  PAX4  SLC26A4  RTEL1  VHL  NEK1  TRNS1  GCM2  TYR  ATP7B  CTHRC1  BRAF  ASXL1  OFD1  MLH1  CDKN1A  PHOX2B  XRCC2  CD19  RB1  FOXC2  TRIM28  EWSR1  TERT  GNA11  F13B  CDKN2A  KARS1  BCL10  TP53  WT1  CDKN2A  FDPS  KIT  COX1  COL14A1  VHL  WT1  TERT  SMAD4  STAR  NUMA1  RPL5  PDGFB  PCGF2  CFTR  KCNQ1OT1  KIT  GJA1  GNAQ  CD27  FANCC  IDH2  EVC2  BRCA2  TCF4  KRAS  PIK3CA  CDC73  ACVR1  BRIP1  TRNW  PRCC  GCGR  CDKN1B  STK11  SCN11A  TGFBR2  AXIN2  ERBB2  RPL35  APC  TSC2  IL12A  SSX2  TET2  KIF1B  DICER1  TRNP  BTK  CCDC22  PDGFRA  ALX3  ADAMTS3  CD81  RET  DKC1  GLI3  FGF3  SMAD4  STK11  ERCC6  WT1  ELANE  C11ORF95  SAMD9L  SLC45A2  NQO2  PTPN11  ATR  PDGFRL  TNFSF12  BRCA2  ADA  BUB1B  FASLG  GDF5  KRAS  CPLANE1  CREBBP  CDC73  CLCNKB  GATA2  CTRC  SDHA  ACTB  APC  BMPER  SPINK1  APC2  MC1R  FOXI1  DYNC2H1  KIT  PPM1D  SDHC  NSD1  SDHC  DDX41  ANTXR1  CASP8  F13A1  SUFU  INS  NUP214  ANTXR2  KIF7  NFKB2  ABCC8  TARS1  ERCC3  TCIRG1  ND4  ERCC2  GNAS  TERT  WASHC5  SLC49A4  RERE  CALR  MSH3  PHOX2B  SLC25A13  BMPR1B  CYLD  SIX6  ASCL1  IDH2  FAN1  CHRNG  CBL  NEUROD1  MSH3  THPO  VANGL1  CDKN2B  TAF15  PTCH2  HMGA2  MSH6  CHEK2  FN1  GATA2  IRF1  KRAS  BMPR1A  NPM1  ERCC3  CDH1  ALK  DNM2  ERBB3  PTPN11  DLST  MUTYH  PARN  GFI1  NBN  FGFR3  CHEK2  EP300  RNF113A  TNFSF15  TEK  TERF2IP  ICOS  COL18A1  TNFSF12  BRAF  CHEK2  IFNG  TMC6  USB1  KDM6B  GJC2  SLC26A2  MDH2  TP53  ENG  MLH1  KRT6B  MNX1  PDGFB  TRNH  POLE  CASP10  HPGD  TET2  RB1  PHOX2B  JAG1  GNB1  ACD  TNFRSF13B  MYC  BRAF  TSC1  SAMD9L  BCL10  H19  POT1  USP8  IGF2  OFD1  CYP11B2  KCNQ1  CDH1  LMX1B  TET2  ANTXR1  JAK2  SMARCB1  ELMO2  PTCH1  SIX1  L2HGDH  WRAP53  BUB3  AXIN1  RET  KCNJ11  ABL1  FANCE  RAD54B  FANCM  TSC2  MAX  IGHM  TSC1  HACE1  CASR  RNF139  MITF  RAF1  WT1  TCTN3  POLH  LIG4  TP53  KRT10  AAGAB  SRY  RAD50  TNFRSF1B  TRNQ  DNASE1L3  FAM149B1  KRT9  VHL  FLCN  TBXT  SLC37A4  DKC1  PNP  DDB2  SETBP1  ECM1  MSH2  CR2  COL2A1  COL7A1  MLH1  FH  SFTPA2  PIK3CA  FOXH1  MET  HNF4A  H19  KAT6B  GPR143  PHB  PMS1  ATP7A  FAT4  TJP2  TFAP2A  GDF2  AHCY  TSC2  CD19  TRNS1  BDNF  TRIP13  AKT1  FGFR2  RAG1  BRCA1  SDHC  MLH1  XRCC3  NSD2  LMNA  SDHC  TERC  EXT2  PIK3CA  MSH3  SDHD  SRC  CHEK2  C1S  ABCA5  HBB  RYR1  FGFR2  CDC73  KIT  FANCE  RET  LYST  KCNJ10  BCHE  HDAC4  INPP5E  CRKL  PHOX2B  BAP1  CPLX1  PDGFRB  ARL6IP6  RNASEL  SETBP1  CTLA4  PALB2  DCLRE1C  NSUN2  XIAP  TRNS2  BMPR1A  IL7R  BCL6  COL4A5  PIK3CA  NOD2  PRKAR1A  NELFA  IL2RG  MYH8  RHBDF2  IGLL1  PIK3CA  SERPINA1  FOXE1  ARHGAP26  TCF4  MITF  ABCB11  ERBB2  GNA14  SLC26A2  NSD1  SH2B3  STK11  PTCH1  GDNF  RPL27  DHCR7  WAS  CIB1  SHH  CACNA1S  LIN28B  SF3B1  ATM  PRKCD  RPS24  LAMA3  ATRX  CASP8  AKT1  OPCML  HFE  SH2D1A  ING1  CCND1  SLC12A3  HABP2  H19  LAMC2  RAD51C  NAB2  NRAS  MAPK1  CPLANE1  CYP26C1  CDKN1B  CHD7  IGH  MYF6  BLM  ASXL1  FH  NEK1  HLA-DRB1  SLC26A4  RPS14  SHOX  RNASEH2C  SMARCD2  GATA2  CDH23  WT1  EPCAM  NR0B1  KLLN  DVL1  SEC23B  GPC3  SLC17A9  BRCA1  SRP54  DKC1  RECQL4  CD28  PTPN11  HRAS  NBEAL2  BARD1  MLH1  DDB2  PMS2  IRF1  ABCC6  EXT2  ASXL1  TSR2  PTEN  MALT1  PTEN  BCR  PALB2  BRIP1  SSX1  PHKA2  FGFR2  SDHB  FERMT1  KCNAB2  FLT3  PMVK  MSTO1  CEP57  MMP1  PICALM  IRF5  TP53  PTPRJ  RNR1  WWOX  PLCD1  RPS28  FGFR3  COL2A1  IKBKG  TERT  RASA1  SAMHD1  PHF21A   hr>