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Report for Mutation I1370K

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Familial Factors in the Development of Colon Cancer

RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer. PURPOSE: Clinical trial to study the cancer-related genes in patients who have colon cancer or adenomatous polyps.

NCT00055848 Colorectal Cancer Genetic: cytogenetic analysis Genetic: gene mapping Genetic: microarray analysis
MeSH: Colonic Neoplasms
HPO: Colon cancer Neoplasm of the colon

DISEASE CHARACTERISTICS: - Diagnosis of colon cancer or polyps at age 70 or under - Has a living full sibling with diagnosis of colon cancer or polyps at age 70 or under - No history of familial adenomatous polyposis syndrome - No hereditary nonpolyposis colon cancer, according to Amsterdam criteria - No known I1370K adenomatous polyposis of the colon susceptibility variant - Enrolled on 1 of the following clinical trials: - CLB-9581 - CLB-89803 - CLB-80001 NOTE: Patients do not need to be receiving protocol therapy. --- I1370K ---

PATIENT CHARACTERISTICS: Age - 70 and under at diagnosis Other - No significant psychiatric illness that would preclude giving informed consent - No inflammatory bowel disease (in patient or sibling) DISEASE CHARACTERISTICS: - Diagnosis of colon cancer or polyps at age 70 or under - Has a living full sibling with diagnosis of colon cancer or polyps at age 70 or under - No history of familial adenomatous polyposis syndrome - No hereditary nonpolyposis colon cancer, according to Amsterdam criteria - No known I1370K adenomatous polyposis of the colon susceptibility variant - Enrolled on 1 of the following clinical trials: - CLB-9581 - CLB-89803 - CLB-80001 NOTE: Patients do not need to be receiving protocol therapy. --- I1370K ---



HPO Nodes


Colon cancer
Genes 59
TP53 TRIP13 COL14A1 SMAD4 BRCA2 MLH1 MSH6 HABP2 PMS2 APC BUB1B PALLD BUB1 GREM1 NTHL1 PMS1 MSH6 AXIN2 APC EPCAM BUB3 MSH2 APC KRAS TGFBR2 FAN1 MINPP1 APC MSH3 SH3KBP1 TP53 KRAS AAGAB SMAD4 BMPR1A MSH2 BMPR1A MLH3 MSH2 PALB2 MUTYH FLCN PIK3CA BMPR1A FOXE1 MSH2 SMAD7 MLH1 CEP57 MLH1 BRCA1 RPS19 PRKAR1A PMS1 APC CDKN2A APC MLH1 APC