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Report for Clinical Trial NCT00190177

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

ECLAXIR:Search for an Association Between CX3CR1 V249I Polymorphism, Preeclampsia and Endothelial Injury

The study hypothesis is the involvement of the couple CX3CR1/CX3CL1 in occurrence of endothelial injury in preeclampsia. According to this hypothesis, Carriers of the I249 allele who express less CX3CR1 shoud be protected against this risk. The main objective of the study is the search of an association between CX3CR1 V249I polymorphism and preeclampsia. The secondary aims are the search of an association with the most severe forms of preeclampsia and endothelial injury.

NCT00190177 Preeclampsia
MeSH: Pre-Eclampsia
HPO: Preeclampsia Toxemia of pregnancy



Time Perspective: Retrospective


There is one SNP

SNPs


1 V249I

ECLAXIR:Search for an Association Between CX3CR1 V249I Polymorphism, Preeclampsia and Endothelial Injury The study hypothesis is the involvement of the couple CX3CR1/CX3CL1 in occurrence of endothelial injury in preeclampsia. --- V249I ---

The main objective of the study is the search of an association between CX3CR1 V249I polymorphism and preeclampsia. --- V249I ---

The frequency of the V249I polymorphism in african black population will be determined by studying 200 subjects (100 cases and 100 controls). --- V249I ---

The V249I polymorphism will be identified by PCR followed by enzyme digestion. --- V249I ---



HPO Nodes


HPO:
Preeclampsia
Genes 18
F5 HELLPAR SLC25A20 CORIN PPARG CFI NOS3 DHPS HBA1 CFH STOX1 CYP11B1 LBR CD46 EP300 HBA2 ADGRG6 CYP11B2
Toxemia of pregnancy
Genes 21
PPARG LMNA F5 NR3C2 HELLPAR SLC25A20 CORIN PPARG CFI NOS3 DHPS HBA1 CFH STOX1 CYP11B1 LBR CD46 EP300 HBA2 ADGRG6 CYP11B2