Aim: This study compared the effectiveness of three different mouthrinses (alcohol and non-alcohol chlorhexidine, alkyl dimethyl glycine / alkyl dimethyl amine oxide - C31G) in plaque control and early wound healing, postoperatively. Materials and Methods: In this, randomized, double-blind, controlled clinical trial 42 patients were allocated to three groups assigned to two weeks rinsing after periodontal surgery with C31G (group A), alcohol-free chlorhexidine 0.12% (group B) or alcohol-based chlorhexidine 0.12% (group C). At weeks 1 and 2, plaque and early wound healing indices were recorded. At day 14, total bacterial counts were estimated utilizing real - time qPCR. Statistics included linear and generalized linear mixed models.
Name: Alcohol-based Chlorhexidine Gluconate 0.12%
Description: Rinsing with 15ml for one minute twice daily for 14 daysType: DrugAlcohol-based Chlorhexidine (Group C)
Name: Alcohol-free Chlorhexidine Gluconate 0.12%
Description: Rinsing with 15ml for one minute twice daily for 14 daysType: DrugAlcohol-free Chlorhexidine (Group B)
Name: C31G
Description: Rinsing with 15ml for one minute twice daily for 14 daysType: DrugC31G (Group A)
Description: EHI measurements range between 1-5: = Complete flap closure-no fibrin line in interproximal area. = Complete flap closure-fibrin line in interproximal area. = Complete flap closure-fibrin clot in the interproximal area. = Incomplete flap closure-partial necrosis of interproximal tissue. = Incomplete flap closure-complete necrosis of the interproximal tissue.
Measure: Assessment of Periodontal Soft Tissue Healing Progress Between Baseline (Immediately After Surgery), 7 and 14 Days Postoperatively (Evaluated by Early Wound Healing Index - EHI) Time: Early Wound Healing Index was recorded at the 7th and 14th postsurgical dayDescription: PI measurements range between 0-3: 0 = No plaque = A film of plaque adhering to the free gingival margin and adjacent area of the tooth. The plaque may be seen in situ only after application of disclosing solution or by using the probe on the tooth surface. = Moderate accumulation of soft deposits on the tooth and gingival margin which can be seen with the naked eye. = Abundance of soft matter on the tooth and gingival margin.
Measure: Plaque Index (PI) Time: PI was recorded 14 days postoperativelyDescription: Assessment of the accumulation of dental plaque at buccal tooth surfaces between baseline (immediately before surgery), 7 and 14 days postoperatively. PA% referred at the percentage of the total buccal surface area of the included teeth covered by dental plaque. PA% values range between 0-100%
Measure: Plaque Area Index (PA%) Time: PA% was recorded at the 7th and 14th postoperative dayDescription: Levels of bacterial counts, expressed in total bacterial DNA mass (ng) and total number of bacteria. TBC was evaluated by real-time Polymerase Chain Reaction (PCR).
Measure: Total Bacterial Counts (TBC) Time: Plaque samples were collected at the 14th postsurgical day.Allocation: Randomized
Parallel Assignment
There is one SNP
Effectiveness of Three Different Mouthrinses in Dental Plaque Control and Early Wound Healing Aim: This study compared the effectiveness of three different mouthrinses (alcohol and non-alcohol chlorhexidine, alkyl dimethyl glycine / alkyl dimethyl amine oxide - C31G) in plaque control and early wound healing, postoperatively. --- C31G ---
Materials and Methods: In this, randomized, double-blind, controlled clinical trial 42 patients were allocated to three groups assigned to two weeks rinsing after periodontal surgery with C31G (group A), alcohol-free chlorhexidine 0.12% (group B) or alcohol-based chlorhexidine 0.12% (group C). --- C31G ---