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Report for Clinical Trial NCT03388099

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Impact of Gonadotrophin REceptor Polimorphisms on the Relationship Between Serum AMH and Ovarian Response

Aim of study: To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.

NCT03388099 antim├╝llerian Hormone and Gonadotrophin Receptor Polymorphism as Predictors of Ovarian Response


Primary Outcomes

Description: To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.

Measure: Gonadotrophin receptor polymorphisms and ovarian response and AMH value

Time: 1 year

Secondary Outcomes

Description: To define the incidence of carriers of polymorphisms in the FSH receptor (FSHR) variant N680S (homozygous and heterozygous) among women undergoing ovarian stimulation for IVF.

Measure: polymorphisms in the FSH receptor (FSHR) variant N680S

Time: 1 year

Description: To define the incidence of carriers of polymorphisms in the LH receptor (LHR) variant N312S (homozygous and heterozygous) among women undergoing ovarian stimulation for IVF.

Measure: polymorphisms in the LH receptor (LHR) variant N312S

Time: 1 year

Description: To analyse the doses of gonadotrophins needed for stimulation on each group of patients

Measure: Doses of gonadotrophin needed and polymorphisms

Time: 1 year

Time Perspective: Prospective

Cohort


There are 2 SNPs

SNPs


1 N312S

To define the incidence of carriers of polymorphisms in the FSH receptor (FSHR) variant N680S (homozygous and heterozygous) among women undergoing ovarian stimulation for IVF.. polymorphisms in the LH receptor (LHR) variant N312S. --- N680S --- --- N312S ---

To define the incidence of carriers of polymorphisms in the LH receptor (LHR) variant N312S (homozygous and heterozygous) among women undergoing ovarian stimulation for IVF.. Doses of gonadotrophin needed and polymorphisms. --- N312S ---


2 N680S

To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.. polymorphisms in the FSH receptor (FSHR) variant N680S. --- N680S ---

To define the incidence of carriers of polymorphisms in the FSH receptor (FSHR) variant N680S (homozygous and heterozygous) among women undergoing ovarian stimulation for IVF.. polymorphisms in the LH receptor (LHR) variant N312S. --- N680S ---



HPO Nodes