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Report for Clinical Trial NCT01001273

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Hyperinsulinemic Normoglycemic Clamp for Pancreas and Simultaneous Pancreas/Kidney Transplant Recipients

This study proposes a simple and safe way of lowering this complicate rate, while improving graft recovering and protecting the graft as it recovers from the transplant. The investigators hypothesize that by maintaining a tight glucose control via a glucose-insulin clamp during surgery and 72 hours post-operatively the investigators will be able to lower the complication rate by 50%.

NCT01001273 Postoperative Complications
MeSH: Postoperative Complications

1 Interventions

Name: Hyperinsulinemic Normoglycemic Clamp

Description: The patient receives insulin intravenous infusion at 2ml units/kg/min. Dextrose 20% (D20W ®) will be titrated to maintain blood glucose between 4 - 6 mmol/L (72 - 108 mg/dl).

Type: Other

Study Group


Primary Outcomes

Measure: The number of post-transplants all complications up to 30 days (Clavien grading).

Time: 30 days post-operative

Secondary Outcomes

Measure: The number of 30 days post-transplant serious medical complication (Clavien grade 3, 4)

Time: 30 days post-op

Measure: The length of hospital stay (days)

Time: Length of hospital stay (day 1 until discharge)

Purpose: Prevention

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 D20W

Inclusion Criteria: - Male or female patient over 18 years of age - Patient is about to receive a pancreas or a simultaneous pancreas/kidney transplant - Able to give written informed consent prior to any study specific procedure Exclusion Criteria: - Multi-organ transplant other than kidney transplant - No central venous access available to deliver the D20W solution Inclusion Criteria: - Male or female patient over 18 years of age - Patient is about to receive a pancreas or a simultaneous pancreas/kidney transplant - Able to give written informed consent prior to any study specific procedure Exclusion Criteria: - Multi-organ transplant other than kidney transplant - No central venous access available to deliver the D20W solution Postoperative Complications Postoperative Complications null --- D20W ---

Inclusion Criteria: - Male or female patient over 18 years of age - Patient is about to receive a pancreas or a simultaneous pancreas/kidney transplant - Able to give written informed consent prior to any study specific procedure Exclusion Criteria: - Multi-organ transplant other than kidney transplant - No central venous access available to deliver the D20W solution Inclusion Criteria: - Male or female patient over 18 years of age - Patient is about to receive a pancreas or a simultaneous pancreas/kidney transplant - Able to give written informed consent prior to any study specific procedure Exclusion Criteria: - Multi-organ transplant other than kidney transplant - No central venous access available to deliver the D20W solution Postoperative Complications Postoperative Complications null --- D20W --- --- D20W ---



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