This study proposes a simple and safe way of lowering this complicate rate, while improving graft recovering and protecting the graft as it recovers from the transplant. The investigators hypothesize that by maintaining a tight glucose control via a glucose-insulin clamp during surgery and 72 hours post-operatively the investigators will be able to lower the complication rate by 50%.
Name: Hyperinsulinemic Normoglycemic Clamp
Description: The patient receives insulin intravenous infusion at 2ml units/kg/min. Dextrose 20% (D20W ®) will be titrated to maintain blood glucose between 4 - 6 mmol/L (72 - 108 mg/dl).Type: OtherStudy Group
Allocation: Randomized
Parallel Assignment
There is one SNP
Inclusion Criteria: - Male or female patient over 18 years of age - Patient is about to receive a pancreas or a simultaneous pancreas/kidney transplant - Able to give written informed consent prior to any study specific procedure Exclusion Criteria: - Multi-organ transplant other than kidney transplant - No central venous access available to deliver the D20W solution Inclusion Criteria: - Male or female patient over 18 years of age - Patient is about to receive a pancreas or a simultaneous pancreas/kidney transplant - Able to give written informed consent prior to any study specific procedure Exclusion Criteria: - Multi-organ transplant other than kidney transplant - No central venous access available to deliver the D20W solution Postoperative Complications Postoperative Complications null --- D20W ---
Inclusion Criteria: - Male or female patient over 18 years of age - Patient is about to receive a pancreas or a simultaneous pancreas/kidney transplant - Able to give written informed consent prior to any study specific procedure Exclusion Criteria: - Multi-organ transplant other than kidney transplant - No central venous access available to deliver the D20W solution Inclusion Criteria: - Male or female patient over 18 years of age - Patient is about to receive a pancreas or a simultaneous pancreas/kidney transplant - Able to give written informed consent prior to any study specific procedure Exclusion Criteria: - Multi-organ transplant other than kidney transplant - No central venous access available to deliver the D20W solution Postoperative Complications Postoperative Complications null --- D20W --- --- D20W ---