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Report for Clinical Trial NCT01105351

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Effect of Mild Increase in Folic Acid Intake on the Distribution of Folate Forms in Relation to a Common Polymorphism in One Folate Catabolising Enzyme

The common polymorphism in MTHFR gene (C677T) has a significant effect on (6S)-5-CH3-H4folate after folic acid supplementation. For example, post supplementation differences in (6S)-5-CH3-H4folate between CC and TT are above 30%.

NCT01105351 the Effect of MTHFR C677T on Folate Metabolism

2 Interventions

Name: folic acid plus B6 and B12

Description: folic acid 400 µg plus vitamin B12 plus B6

Type: Dietary Supplement

folic acid plus B6 and B12

Name: folic acid

Description: folic acid 400 µg

Type: Dietary Supplement

Folic acid


Primary Outcomes

Description: we will measure primary folate forms after folic acid supplement

Measure: blood metabolic markers

Time: 18 months

Purpose: Basic Science

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 C677T

Effect of Folic Acid on Primary Folate Forms in Relation to MTHFR The common polymorphism in MTHFR gene (C677T) has a significant effect on (6S)-5-CH3-H4folate after folic acid supplementation. --- C677T ---

methotrexate) treatment - Ileum resection - Current B-vitamin supplement - Epilepsy medications - Megaloblastic anemia or other indications for treatment with high doses of folate or vitamin B12. the Effect of MTHFR C677T on Folate Metabolism The investigators aim to test the effect of low doses of folic acid with or without B6 and B12 on folate forms in relation to polymorphisms in folate catabolising enzymes in elderly people. --- C677T ---



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