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Report for Clinical Trial NCT01016444

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

β2AR Polymorphisms and Albuterol Responsiveness in Acute Asthma

The hypothesis to be tested is that acutely ill asthmatics who do not resolve their attacks following standard doses of albuterol and require admission to hospital have single nucleotide polymorphisms of their B2 adrenergic receptors that lower B2 agonist responsivity.

NCT01016444 Acute Asthma
MeSH: Asthma
HPO: Asthma


Primary Outcomes

Measure: B2AR polymorphisms associated with albuterol responsiveness in acute asthma.

Time: ~ 1 hour following 3 doses of albuterol Q 20 min

Secondary Outcomes

Measure: B2AR haplotypes

Time: ~ 1hr post 3 doses of albuterol

Time Perspective: Prospective

Case Control


There are 2 SNPs

SNPs


1 G16R

The results of this study will demonstrate whether Gly16Arg or Gln27Glu genotypes and/or β2AR haplotypes are associated with the response to albuterol in patients who experience acute episodes of asthma and whether genotype pattern varies between different clinical phenotypes. --- Gly16Arg ---


2 Q27E

The results of this study will demonstrate whether Gly16Arg or Gln27Glu genotypes and/or β2AR haplotypes are associated with the response to albuterol in patients who experience acute episodes of asthma and whether genotype pattern varies between different clinical phenotypes. --- Gly16Arg --- --- Gln27Glu ---



HPO Nodes


HPO:
Asthma
Genes 138
DNAH9 COL5A2 DNAH11 NFKB2 TDGF1 DDX41 SPAG1 ARMC4 GP1BA GAS2L2 CCDC151 ERCC2 TNF SPINK5 GP1BB GAS1 TGIF1 CCL11 CDON DLL1 CFAP221 PTGER2 TBX21 LRBA RSPH4A CFTR FLG NME8 DNAAF4 ZIC2 SCGB3A2 CCDC65 SDHD ADRB2 TBX1 GP1BB SIX3 IDS NODAL NSUN2 ELOVL4 PEPD CARMIL2 CFAP300 FGF8 GP9 FOXJ1 DNAI1 CASP8 DOCK8 CCDC151 DISP1 IL13 CCNO ALMS1 RSPH1 CCDC39 STK36 MUC7 NOD2 CARD11 CCDC28B DNAL1 DNAH1 ZMYND10 RSPH3 RSPH9 MS4A2 PLA2G7 HNMT DRC1 NKX2-1 SHH COL1A1 CCDC103 SPINK5 FGFR1 DNAAF3 MTOR HIRA LRRC56 LRRC6 GAS8 CFAP298 NEK9 CCDC40 IL4R PGM3 DOCK8 DNAAF2 GLI2 RREB1 TGFB1 PTCH1 GRHL2 SIK3 SCN4A BBS1 TALDO1 DNAAF1 NKX2-1 OFD1 TRAIP PLCG2 HLA-G COL5A1 ALMS1 DNAI2 BCL11B LIG4 GTF2H5 PGM3 ARVCF PEX5 CDSN SEC24C DNAAF6 DNAH5 CCDC114 ADA PLA2G7 JMJD1C DNAJB13 RPGR FOXH1 ALOX5 TTC25 FCGR2A TBX1 COMT COX4I2 UFD1 SPEF2 SUFU DNAAF5 LIFR MCIDAS HYDIN