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Report for Clinical Trial NCT01074398

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

ERCC1 Expression as a Predictor of Progression Free and Overall Survival in Patients With Epithelial Ovarian Cancer Treated on GOG Protocols 0172 and 0182

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how well patients will respond to treatment. PURPOSE: This research study is looking at biomarkers in predicting response in patients with advanced ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer.

NCT01074398 Fallopian Tube Cancer Ovarian Cancer Peritoneal Cavity Cancer
MeSH: Ovarian Neoplasms Carcinoma, Ovarian Epithelial Fallopian Tube Neoplasms
HPO: Fallopian tube carcinoma Ovarian neoplasm

5 Interventions

Name: gene expression analysis

Type: Genetic

Name: polymorphism analysis

Type: Genetic

Name: protein expression analysis

Type: Genetic

Name: immunohistochemistry staining method

Type: Other

Name: laboratory biomarker analysis

Type: Other


Primary Outcomes

Measure: Association between ERCC1 tumor expression and progression-free and overall survival

Secondary Outcomes

Measure: Association between ERCC1 polymorphisms and ERCC1 tumor expression

There is one SNP

SNPs


1 C8092A

Secondary - To correlate ERCC1 single-nucleotide polymorphisms (C8092A and codon 118) with ERCC1 tumor expression. --- C8092A ---



HPO Nodes


HPO:
Fallopian tube carcinoma
Ovarian neoplasm
Genes 86
VAMP7 ZFPM2 CTNNB1 PTEN AKT1 WT1 FGFR2 AKT1 OPCML SOX9 BRCA2 BRCA1 PTEN MLH1 SUFU EWSR1 PMS2 IDH1 LMNA RAD51C RAD51C STAG3 GATA4 PALLD PIK3CA CHEK2 BRIP1 MRE11 FGFR2 TP53 RAD51D PRKN MSH6 EPCAM WT1 NR0B1 WT1 KRAS DICER1 TGFBR2 IDH2 SRY BRCA1 FAN1 DMRT3 MSH3 TP53 KRAS NR5A1 INHBA RNF43 KEAP1 DICER1 BARD1 SMAD4 RAD50 MSH2 NBN WNT10A C11ORF95 MLH3 PTCH2 CDH1 WRN PTEN PALB2 MAP3K1 PIK3CA RELA MAP3K1 PALB2 WT1 PMS2 BRCA2 PTEN BRCA1 RAD51 BRCA1 BRCA2 PTCH1 FLI1 PTEN PMS1 PTCH1 CDKN2A WWOX