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Report for Clinical Trial NCT01936051

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Modeling Between Plasma Concentration and Serotonin Transporter Occupancy Induced by Escitalopram in Obsessive-compulsive Disorder(OCD) Patients

To modeling the pharmacokinetic-pharmacodynamic(PK-PD) simulation with the plasma concentration and the transporter occupancy from OCD patients treated with escitalopram. To examine the effect of G2677T/A single nucleotide polymorphism(SNP) of ABCB1 gene to the PK-PD modeling in OCD patients treated with escitalopram.

NCT01936051 OCD
MeSH: Compulsive Personality Disorder Obsessive-Compulsive Disorder
HPO: Obsessive-compulsive behavior


Primary Outcomes

Measure: serotonin transporter occupancy

Time: 72hr after oral administration of escitalopram

Secondary Outcomes

Measure: genotype

Time: baseline

Description: scale for the severity of Obsessive-compulsive symptoms

Measure: Yale-Brown Obsessive Compulsive Scale(Y-BOCS) Score

Time: baseline

Description: serotonin transporter occupancy measured at 5 hour and 24 hour after oral dose of escitalopram

Measure: serotonin transporter occupancy

Time: within the first 24hrs after oral administration of escitalopram

Description: plasma concentration of escitalopram at baseline, 1, 2, 3, 5, 8, 10, 24, 48, 72 hour after oral dose of escitalopram

Measure: escitalopram plasma concentration

Time: within 72 hours after oral administration of escitalopram

Time Perspective: Other

Other


There is one SNP

SNPs


1 G2677T

To examine the effect of G2677T/A single nucleotide polymorphism(SNP) of ABCB1 gene to the PK-PD modeling in OCD patients treated with escitalopram. --- G2677T ---

To genotype G2677T/A SNP of ABCB1 gene in OCD patients treated with escitalopram. --- G2677T ---



HPO Nodes


HPO:
Obsessive-compulsive behavior
Genes 96
GRN GATAD2B HCN1 ARID1B GTF2I CHMP2B BAZ1B EHMT1 MLXIPL SLC35C1 CLIP2 TREM2 PAH RAD21 TOR1A AFF2 UBE3A SGCE GABRD MED12 SCN9A TBX1 MAPK1 TMEM106B STX1B ELN CLCN4 MAPT GABRG2 SGCE OCRL SLC6A4 RFC2 TKT HDC HTR2A PSEN1 PCDH19 UBE2A CLCN4 C9ORF72 NKX2-1 SCN1A HDAC4 COASY YWHAG CRKL KMT2A SCN2A GCH1 ADGRV1 TBL2 XK DPF2 TRRAP SLC45A1 GTF2IRD1 SETD5 AFF2 HDAC8 FMR1 ELN SEMA3E TLK2 PANK2 TRIO SMC3 VCP POGZ AUTS2 TCF20 HNRNPH2 BCR CHD7 DRD2 ALMS1 SETD5 TTC19 PANK2 SQSTM1 SCN1B LIMK1 DMPK SLITRK1 MED12 COASY SETD5 PPM1D FMR1 ADNP KCTD17 NIPBL ADNP SMC1A SLITRK1 TRIO