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Report for Clinical Trial NCT00378469

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Study of the Effects of Muscular Activity on Iron Metabolism: A Pilot Study on Healthy Volunteers

The aim of this study is to evaluate the effect of muscular exercise on iron metabolism in healthy volunteers. Fourteen healthy male subjects will have to pedal on an ergocycle for 45 minutes, and urine and blood samples will be collected regularly to measure hemojuvelin, hepcidin, iron and transferrin levels.

NCT00378469 Iron Overload Iron Deficiency
MeSH: Iron Overload

1 Interventions

Name: 45 minute exercise on ergocycle

Type: Behavioral


Primary Outcomes

Measure: Pharmacokinetics of urinary hepcidin

Measure: Pharmacokinetics of blood hemojuvelin

Secondary Outcomes

Measure: Pharmacokinetics of urine and blood iron, transferrin, interleukin-6 (IL-6) and ferritin

Allocation: Randomized

Crossover Assignment


There is one SNP

SNPs


1 C282Y

Inclusion Criteria: - Male individuals aged between 18 and 40 years old - Body mass index (BMI) between 18 and 25 - Normal at clinical examination - Normal biological variables - Written informed consent Exclusion Criteria: - Mutation C282Y of the HFE gene - Iron metabolism abnormality - Inflammatory syndrome - Chronic pathology or ongoing treatment - Tobacco smoking, alcohol consuming more than 30g/day - History of transfusion or blood-giving within 3 months - Positive serology for hepatitis B virus (HBV), hepatitis C virus (HCV) or HIV. --- C282Y ---



HPO Nodes