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Report for Clinical Trial NCT03029858

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Programmed Death-ligand 1(PD-L1) and Other Immuno-markers Influenced by Osimertinib Treatment in Advanced Non-small Cell Lung Cancer (NSCLC) Patients

The study will investigate whether PD-L1 and other immuno-markers will be influenced by osimertinib treatment in advanced epidermal growth factor receptor (EGFR)T790M positive advanced NSCLC patients. In addition, we will explore whether PD-L1 and other immuno-markers can predict the safety and efficacy of subsequent use of immune checkpoint inhibitors at the time of PD due to osimertinib resistance.

NCT03029858 Small Cell Lung Cancer, Polygonal Type
MeSH: Lung Neoplasms Small Cell Lung Carcinoma
HPO: Neoplasm of the lung Small cell lung carcinoma

1 Interventions

Name: No interventions will be taken in this Observational study

Description: TAGRISSO(osimertinib/AZD9291)

Type: Other


Primary Outcomes

Description: Measure PD-L1 value Change by tumor cells(TC)/immune cells(IC) staining from the baseline to progressive disease(PD)

Measure: Measure PD-L1 value

Time: baseline and PD,up to 24 months

Description: Measure PD-L1 expression positive rate (%) change from the baseline to progressive disease(PD)

Measure: Measure PD-L1 expression positive rate (%)

Time: baseline and PD,up to 24 months

Time Perspective: Other

Case-Only


There is one SNP

SNPs


1 T790M

Small Cell Lung Cancer, Polygonal Type Lung Neoplasms Small Cell Lung Carcinoma Investigate whether PD-L1 and other immuno-markers will be influenced by osimertinib treatment in advanced EGFR T790M positive advanced NSCLC patients. --- T790M ---



HPO Nodes


HPO:
Neoplasm of the lung
Genes 61
REST GPC3 WT1 HPGD BRAF PIK3CA TP53 TRIM28 RB1 TRIP13 SLCO2A1 AKT1 CASP8 KRAS TSC1 POU6F2 EWSR1 PRKN LMNA NAB2 TERT TSC2 SLC22A18 BRCA2 PPP2R1B STAT6 STK11 MUC5B ERBB2 TSC2 MBTPS2 BAP1 TSC2 DICER1 PDGFRB PERP EGFR TSC1 DIS3L2 NOTCH3 KEAP1 DICER1 DICER1 WT1 TSC1 C11ORF95 IRF1 CYP2A6 WRN RELA WT1 PTEN SFTPC SFTPA2 ERCC6 TRPV3 TP53 H19 TRIM28 FASLG MAP3K8
Small cell lung carcinoma