SNPMiner Trials (Home Page)
Report for Clinical Trial NCT00579683
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
The purpose of this study is to try to learn more about how small molecule kinase inhibitors
work in treating lung cancer. Some early studies have shown that gefitinib, erlotinib and
similar drugs are more likely to work if a particular DNA change (also known as a mutation)
is found in a protein that is important in lung cancer. This protein is called the epidermal
growth factor receptor (EGFR). Since small molecule kinase inhibitors sometimes stop working,
we would like to examine your tumor to learn why these medicines are not working as well.
Your tumor will be examined for a variety of things including changes in the DNA of the EGFR.
We will also sequence parts of the genes for HER2, HER3, HER4, and KRAS, other proteins
thought to be important in lung cancer.
Name: Tumor core biopsy for RNA isolation
Description: RNA isolation will be carried out using approximately 25 mg of gross tissue from these tumor specimens.Type: Other
1
Primary Outcomes
Measure: To compare EGFR gene sequence in patients upon relapse with EGFR gene sequence prior to treatment with small molecule kinase inhibitors.
Time: 2 years
Secondary Outcomes
Measure: To identify novel mutations in the tyrosine kinase domain of EGFR in patients with acquired resistance to small molecule kinase inhibitors.
Time: 2 years
Measure: To more precisely characterize the frequency and clinical implications of T790M in patients with acquired resistance to small molecule kinase inhibitors.
Time: 2 years
Measure: To identify novel mechanisms of acquired resistance to EGFR small molecule kinase inhibitors.
Time: 2 years
Time Perspective: Prospective
Case-Only
There is one SNP
SNPs
1 T790M
To more precisely characterize the frequency and clinical implications of T790M in patients with acquired resistance to small molecule kinase inhibitors.. null. --- T790M ---
HPO Nodes
HPO:Neoplasm of the lung
Genes 61
REST GPC3 WT1 HPGD BRAF PIK3CA TP53 TRIM28 RB1 TRIP13 SLCO2A1 AKT1 CASP8 KRAS TSC1 POU6F2 EWSR1 PRKN LMNA NAB2 TERT TSC2 SLC22A18 BRCA2 PPP2R1B STAT6 STK11 MUC5B ERBB2 TSC2 MBTPS2 BAP1 TSC2 DICER1 PDGFRB PERP EGFR TSC1 DIS3L2 NOTCH3 KEAP1 DICER1 DICER1 WT1 TSC1 C11ORF95 IRF1 CYP2A6 WRN RELA WT1 PTEN SFTPC SFTPA2 ERCC6 TRPV3 TP53 H19 TRIM28 FASLG MAP3K8 hr>Non-small cell lung carcinoma
Genes 3
TP53 TP53 BAP1 hr>