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Report for Clinical Trial NCT00830245
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
To assess the efficacy and safety of erlotinib for non-small cell lung cancer patients with
leptomeningeal carcinomatosis
Name: Erlotinib
Description: Erlotinib 150mg/dayType: Drug
Erlotinib
Primary Outcomes
Measure: Overall survival
Time: 1 year
Secondary Outcomes
Measure: Cytology negative conversion rate
Time: 1 month, 2 months, 3 months, 4 months
Measure: Neurologic symptom improvement
Time: 1 month, 2 months, 3 months, 4 months
Measure: Response rate (extra-cranial disease)
Time: 2 months, 4 months
Measure: Response rate (brain)
Time: 2 months, 4 months
Measure: Quality of life
Time: 1 month, 2 months, 3 months, 4 months
Measure: Toxicities
Time: 1 month, 2 months, 3 months, 4 months
Measure: Prognostic factors
Time: N-A
Purpose: Treatment
Allocation: Non-Randomized
Single Group Assignment
There is one SNP
SNPs
1 L858R
Inclusion Criteria:
1. Age >18
2. Histologically or pathologically proven non-small cell lung cancer (NSCLC)
3. Leptomeningeal carcinomatosis confirmed by CSF cytology
4. A patients with EGFR mutation (including exon 19 deletion, L858R)
5. ECOG performance status 0-3
6. Expected life time more than at least 4 weeks
7. --- L858R ---
A patient who refused to sign the informed consent
Inclusion Criteria:
1. Age >18
2. Histologically or pathologically proven non-small cell lung cancer (NSCLC)
3. Leptomeningeal carcinomatosis confirmed by CSF cytology
4. A patients with EGFR mutation (including exon 19 deletion, L858R)
5. ECOG performance status 0-3
6. Expected life time more than at least 4 weeks
7. --- L858R ---
HPO Nodes
HPO:Carcinoma
Genes 16
POLE MSH2 DKC1 SMARCA4 NLRP1 POLD1 CDKN1B MLH1 RSPO1 FGFR3 BCL10 APC STK11 PTEN APC KIT hr>Neoplasm of the lung
Genes 61
REST GPC3 WT1 HPGD BRAF PIK3CA TP53 TRIM28 RB1 TRIP13 SLCO2A1 AKT1 CASP8 KRAS TSC1 POU6F2 EWSR1 PRKN LMNA NAB2 TERT TSC2 SLC22A18 BRCA2 PPP2R1B STAT6 STK11 MUC5B ERBB2 TSC2 MBTPS2 BAP1 TSC2 DICER1 PDGFRB PERP EGFR TSC1 DIS3L2 NOTCH3 KEAP1 DICER1 DICER1 WT1 TSC1 C11ORF95 IRF1 CYP2A6 WRN RELA WT1 PTEN SFTPC SFTPA2 ERCC6 TRPV3 TP53 H19 TRIM28 FASLG MAP3K8 hr>Non-small cell lung carcinoma
Genes 3
TP53 TP53 BAP1 hr>