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Report for Clinical Trial NCT01720758

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Assessment of the V600E Mutation in the B-RAF Gene in Chronic Lymphoproliferative Disease.

The presence of a specific mutation in the gene known as B-RAF has been found in patients who have Hairy Cell Leukemia. In this study this specific mutation known as V600E will be ascertained in peripheral blood samples of patients who have this disease and in a group of patients who have a similar chronic lymphoproliferative conditions such as splenic marginal lymphoma. The finding of this specific mutation will help to verify or exclude the diagnosis of Hairy Cell Leukemia and determine whether patients are in remission.

NCT01720758 Hairy Cell Leukemia Splenic Marginal Zone Lymphoma
MeSH: Lymphoma, B-Cell, Marginal Zone Leukemia, Hairy Cell Lymphoproliferative Disorders
HPO: Lymphoproliferative disorder


Primary Outcomes

Measure: detection of the B-RAF V600E mutation

Time: 2 weeks

Time Perspective: Prospective

Other


There is one SNP

SNPs


1 V600E

Assessment of the V600E Mutation in the B-RAF Gene in Chronic Lymphoproliferative Disease.. Assessment of the V600E Mutation in the B-RAF Gene in Chronic Lymphoproliferative Disease The presence of a specific mutation in the gene known as B-RAF has been found in patients who have Hairy Cell Leukemia. --- V600E ---

Assessment of the V600E Mutation in the B-RAF Gene in Chronic Lymphoproliferative Disease.. Assessment of the V600E Mutation in the B-RAF Gene in Chronic Lymphoproliferative Disease The presence of a specific mutation in the gene known as B-RAF has been found in patients who have Hairy Cell Leukemia. --- V600E --- --- V600E ---

In this study this specific mutation known as V600E will be ascertained in peripheral blood samples of patients who have this disease and in a group of patients who have a similar chronic lymphoproliferative conditions such as splenic marginal lymphoma. --- V600E ---

detection of the B-RAF V600E mutation. --- V600E ---



HPO Nodes


HPO:
Lymphoproliferative disorder
Genes 9
KRAS ZAP70 MYD88 NRAS IL2RG MYD88 CD70 MCM4 CD27