development of skin adhesive patches for the monitoring and prediction of mental disorders
Name: cognitive stress (serial 7)
Type: BehavioralMajor depressive disorder normal control panic disorder
Description: changes of skin conductane level(SCL) and skin conductance response(SCR)
Measure: Electrodermal activity(EDA) Time: baseline, 0.5, 1,2,3 monthsDescription: changes of SDNN, RMSSD and LF/HF ratio
Measure: Heart rate variability Time: baseline, 0.5, 1,2,3 monthsDescription: IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12(p70), IFN-γ, TNF-α
Measure: Cytokines Time: baseline, 0.5, 1,2,3 monthsDescription: serum, plasma, platelet BDNF
Measure: BDNF Time: baseline, 0.5, 1,2,3 monthsDescription: structured interview assessing for DSM-IV Axis I disorders with strong reliability and validity in relation to the Structured Clinical Interview for DSM-IV (SCID-IV)
Measure: MINI plus Time: BaselineDescription: assess current and past Axis I diagnoses
Measure: MINI Suicidality Module Time: baseline, 0.5, 1,2,3 monthsDescription: changes of HAMD-17 total socres
Measure: Hamilton Depression Rating Scale-17(HAMD-17) Time: baseline, 0.5, 1,2,3 monthsDescription: changes of HAMA total scores
Measure: Hamilton Anxiety Rating Scale(HAMA) Time: baseline, 0.5, 1,2,3 monthsDescription: ASI-3 to measure the three most supported AS domains: social (i.e., fear of exhibiting symptoms in public that may elicit embarrassment), cognitive (i.e., fear of losing cognitive control or experiencing concentration difficulties), and physical (i.e., fear that physical sensations are a sign of an immediate physical problem).
Measure: Anxiety Sensitivity Index(ASI) Time: baseline, 0.5, 1,2,3 monthsDescription: The APPQ (Rapee et al., 1995) is a 27-item instrument that is designed to measure interoceptive, agoraphobic, and social situational fear. Subjects respond to each item on a 9-point Likert scale from 0 to 8, according to how much fear they think they would experience in a given situation so that total scores range from 0 to 216.
Measure: APPQ(Albany Panic and Phobia Questionnaire) Time: baseline, 0.5, 1,2,3 monthsDescription: 16-item questionnaire that aims to measure the trait of worry, using Likert rating from 1 (not at all typical of me) to 5 (very typical of me)
Measure: PSWQ(Penn state worry questionnaire) Time: baseline, 0.5, 1,2,3 monthsDescription: emotional, somatic, cognitive, and behavioral stress responses.
Measure: SRI(Stress response Inventory) Time: baseline, 0.5, 1,2,3 monthsDescription: The Perceived Stress Scale (PSS) is the most widely used psychological instrument for measuring the perception of stress. It is a measure of the degree to which situations in one's life are appraised as stressful.
Measure: Perceived Stress Scale(PSS) Time: baseline, 0.5, 1,2,3 monthsDescription: The Barratt Impulsiveness Scale (BIS) is a widely used measure of impulsiveness. It includes 30 items that are scored to yield six first-order factors (attention, motor, self-control, cognitive complexity, perseverance, and cognitive instability impulsiveness) and three second-order factors (attentional, motor, and non-planning impulsiveness).The BIS-11 is a 30-item self-report questionnaire, that is scored to yield a total score, three second-order factors, and six first-order factors.
Measure: Barratt Impulsivity Scale Time: baseline, 0.5, 1,2,3 monthsDescription: The items assess panic frequency, distress during panic, panic-focused anticipatory anxiety, phobic avoidance of situations, phobic avoidance of physical sensations, impairment in work functioning, and impairment in social functioning. The overall assessment is made by a total score, which is calculated by summing the scores for all seven items. The total scores range from 0 to 28.
Measure: Panic disorder severity scale(PDSS) Time: baseline, 0.5, 1,2,3 monthsAllocation: Non-Randomized
Parallel Assignment
There is one SNP
Brain-derived neurotrophic factor(BDNF) genotyping: Val66Met. --- Val66Met ---