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Report for Clinical Trial NCT02722668

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Transplantation of Umbilical Cord Blood From Unrelated Donors in Patients With Hematological Diseases Using a Non-Myeloablative Preparative Regimen

This is a phase II trial using a non-myeloablative cyclophosphamide/ fludarabine/total body irradiation (TBI) preparative regimen with modifications based on factors including diagnosis, disease status, and prior treatment. Single or double unit selected according to current University of Minnesota umbilical cord blood graft selection algorithm.

NCT02722668 Acute Leukemia Acute Myeloid Leukemia Acute Lymphoblastic Leukemia/Lymphoma Burkitt's Lymphoma Natural Killer Cell Malignancies Chronic Myelogenous Leukemia Myelodysplastic Syndrome Large-cell Lymphoma Hodgkin Lymphoma Multiple Myeloma Relapsed Chronic Lymphocytic Leukemia Relapsed Small Lymphocytic Lymphoma Marginal Zone B-cell Lymphoma Follicular Lymphoma Lymphoplasmacytic Lymphoma Mantle-cell Lymphoma Prolymphocytic Leukemia Bone Marrow Failure Syndromes Myeloproliferative Neoplasms/Myelofibrosis Biphenotypic/Undifferentiated/Prolymphocytic Leukemias MRD Positive Leukemia Leukemia or MDS in Aplasia Relapsed T-Cell Lymphoma Relapsed Multiple Myeloma Plasma Cell Leukemia
MeSH: Burkitt Lymphoma Lymphoma Leukemia Multiple Myeloma Neoplasms, Plasma Cell Precursor Cell Lymphoblastic Leukemia-Lymphoma Leukemia, Lymphocytic, Chronic, B-Cell Lymphoma, Mantle-Cell Leukemia, Myelogenous, Chronic, BCR-ABL Positive Lymphoma, B-Cell, Marginal Zone Leukemia, Prolymphocytic Waldenstrom Macroglobulinemia Leukemia, Plasma Cell Myelodysplastic Syndromes Myeloproliferative Disorders Pancytopenia Hematologic Diseases Syndrome
HPO: Abnormality of blood and blood-forming tissues Burkitt lymphoma Chronic lymphatic leukemia Chronic myelogenous leukemia Leukemia Lymphoma Monoclonal immunoglobulin M proteinemia Multiple myeloma Myelodysplasia Myeloproliferative disorder Pancytopenia

7 Interventions

Name: Fludarabine

Description: Both Arms: 30 mg/m^2 IV over 1 hour Day -6 to Day -2

Type: Drug

ATG No ATG

Name: Cyclophosphamide

Description: Arm 1: 50 mg/kg IV over 2 hours Day -6

Type: Drug

ATG No ATG

Name: MMF

Description: Both Arms: Mycophenolate mofetil (MMF) 3 gram/day IV/PO for patients who are ≥ 40 kg divided in 2 or 3 doses. In obese patients (>125% IBW) 15 mg/kg every 12 hours may be considered. Pediatric patient (<40 kilograms) will receive MMF at the dose of 15 mg/kg/dose every 8 hours beginning Day -3. MMF dosing will be monitored and altered as clinically appropriate based on institutional guidelines. Patients will be eligible for MMF dosing and pharmacokinetics studies. Stop MMF at Day +30 or 7 days after engraftment, whichever day is later, if no acute graft versus host disease (GVHD). (Definition of engraftment is 1st day of 3 consecutive days of absolute neutrophil count [ANC) ≥ 0.5 x 109 /L]). If no donor engraftment, do not stop MMF.

Type: Drug

ATG No ATG

Name: Sirolimus

Description: Both Arms: Adult Dosing: Sirolimus will be administered starting at Day -3 with 8-12 mg oral loading dose followed by single dose 4 mg/day with a target serum concentration of 3 to 12 mg/mL by high-performance liquid chromatography (HPLC) and will be monitored per institutional guidelines. In the absence of acute GVHD sirolimus may be tapered starting at Day +100 and eliminated by Day +180 post-transplantation. Pediatric Dosing: Sirolimus will be administered starting on Day -3 with an oral loading dose of 10 mg followed by maintenance dosing of 2.5 mg/m^2/day (Maximum total daily dose of 4mg) as per institutional guidelines. Target serum concentration goals are 3 to 12 mg/mL by high-performance liquid chromatography (HPLC) and will be monitored per institutional guidelines.

Type: Drug

ATG No ATG

Name: TBI

Description: Both Arms: 200 cGy on Day -1

Type: Radiation

ATG No ATG

Name: Umbilical cord blood cell infusion

Description: Both Arms: Day 0

Type: Biological

ATG No ATG

Name: ATG

Description: Arm 2: 15 mg/kg IV every 12 hours Day -6 to Day -4

Type: Biological

ATG


Primary Outcomes

Description: Simple proportions will be used to estimate the probability of grade II-IV actue GVHD.

Measure: Probability of Acute Graft Versus Host Disease (GVHD)

Time: Day 100

Secondary Outcomes

Description: Percentage of patients with grade III-IV acute GVHD.

Measure: Incidence of Acute GVHD

Time: Day 100

Measure: Transplant related mortality

Time: 6 months post transplant

Description: Percentage of subjects with donor chimerism.

Measure: Chimerism

Time: Day 21

Description: Percentage of subjects with donor chimerism.

Measure: Chimerism

Time: Day 100

Description: Percentage of subjects with donor chimerism.

Measure: Chimerism

Time: Day 180

Description: Percentage of subjects with donor chimerism.

Measure: Chimerism

Time: 1 year post transplant

Description: Percentage of subjects with neutrophil engraftment.

Measure: Neutrophil Engraftment

Time: Day 42

Purpose: Treatment

Allocation: Non-Randomized

Parallel Assignment


There is one SNP

SNPs


1 T315I

t(9;22), t(1;19), t(4;11), other MLL rearrangements, IKZF1 - 30 years of age or older at diagnosis - White blood cell counts of greater than 30,000/mcL (B-ALL) or greater than 100,000/mcL (T-ALL) at diagnosis - CNS leukemia involvement during the course of disease - Slow cytologic response (>10% lymphoblasts in bone marrow on Day 14 of induction therapy) - Evidence of persistent immonophenotypic or molecular minimal residual disease (MRD) at the end of induction and consolidation therapy - Biphenotypic/Undifferentiated/Prolymphocytic Leukemias in first or subsequent CR - Chronic myelogenous leukemia in chronic or accelerated phase, or CML blast crisis in morphological remission (<5% blasts): Chronic phase patients must have failed at least two tyrosine kinase inhibitors, been intolerant to all available TKIs, or have T315I mutation. --- T315I ---



HPO Nodes


HPO:
Abnormality of blood and blood-forming tissues
Genes 1848
PIEZO1 TNFRSF11A HBA2 BIRC3 PRKAR1A KIT COL5A1 ATRX CYP11B1 CASP10 PIGL F2 TET2 ATRX LMBRD1 LAMA3 SLC40A1 KIT GLI1 PROC HMCN1 PEPD EPB41 CASP10 NBAS NGLY1 ABCA1 NEDD4L WAS MARS1 REN ENPP1 PLG LRP5 GBA TREX1 DYNC2LI1 RPS14 TNFAIP3 TINF2 TYROBP ADAMTS2 NPC2 CYP7B1 BLK KCNJ11 CYB5A HIRA SLC19A2 GP1BA RNASEH2C ANKRD26 SLC22A4 CD3G BUB1B TAF1A DOCK8 GDF2 HLCS SPTA1 SMPD1 BCOR HLA-DPB1 NDUFS1 PET100 BCR APP JAK2 SSR4 IL10 IFNG SLC17A5 MLLT10 BCL11B NOTCH3 BMPR1A CALR RAG2 CDAN1 FCGR2A NDUFAF2 COG6 SUFU RUNX1 ACP2 IFNG ITGB4 SDHC HPRT1 ISCU COL5A1 MTTP SMAD3 TGFBR1 CD247 MET IGH GFI1B ATP6V0A2 COA8 DNMT3A VWF RPS26 ACVRL1 VPS33B GATA1 FOXE3 NCF1 TAL1 RECQL4 SMAD4 TPP2 RNU4ATAC ITGA2B SDHA SH2B3 PRKACG PDGFB PIGM ERCC4 C1R RMRP ALG6 WIPF1 CD81 F7 ADAMTS2 NOS3 GATA6 CHD7 SMAD4 SRP72 DOCK8 FLI1 BRCA1 TAZ SLC2A1 TERT HBA2 NDUFB8 HBB GATA1 TMPO MTOR MTHFR CR2 HAVCR2 SERPINF2 MYH6 SDHB AKR1D1 CD59 NHLRC2 MPI DCLRE1C GLB1 TMPRSS6 KRIT1 STK4 NEBL SAA1 NDUFA12 EWSR1 COG4 ACTN1 MYORG SDHD EPHB2 MRAS AGGF1 GTF2E2 SMAD3 ESCO2 TGFB1 GPI PDGFRB RNASEH2A CEBPE TGFBR2 DGKE MTFMT APC ABCB7 ITGB3 FCGR2C KIT F9 ABHD5 RAD54L GFI1 SPATA5 GLA SLC30A10 MAP2K2 NDP PIK3R1 CTSK STIM1 KLF1 VHL COL7A1 CST3 SFXN4 HBB DPM2 SLC25A13 RAD51C RMRP ANK1 KCNJ11 CD40 DLD LRP5 ATM COL5A2 RPL35A PSEN1 BCL10 LPP CCR1 ERCC2 GP1BA HBA1 JAK2 ACAD9 TFR2 FANCD2 ATP6V0A2 IREB2 KIF15 SOS1 NEXN STT3B F11 ATRX CTRC TGFBR2 PTPN11 HPS3 HBA1 PTEN RS1 WIPF1 NDUFS3 TNFRSF1B LBR SLC37A4 CXCR4 KIT TNFRSF13B CYSLTR2 CORO1A TRNQ PTPN22 TRNN CD55 ALG12 MEFV CCM2 SCARB2 FANCI GP9 NT5C3A UMPS WAS CD247 ANKRD1 GFI1B AK2 MAD2L2 RFXANK ELMO2 CARD11 PTH1R ACTC1 MYH11 SMARCAL1 JAGN1 LYST MSH2 GPR35 FANCA NSMCE2 CYBC1 HLA-DPA1 LBR ANKRD11 SLX4 RAG2 KRT14 DPM1 CLCN7 FARSB RNASEH2A SPARC CISD2 DNAJC21 TGFBR2 ADA PLVAP AKT1 KMT2D NOTCH1 GCLC TNFRSF1A IL7R IL10 FUT8 RFWD3 TMEM67 NPHP1 BRAF CYP7B1 ACAT1 RFX5 ITGB3 MTRR MLH3 MLF1 PRSS1 POLE ACSL4 FARS2 RASA1 MTAP VPS13B CUBN ALPL IGHM SDHB CFTR PALB2 COL3A1 GFI1 GBA HNF1A F5 MMADHC ATP7A FECH ABCD4 ACD ITGB3 HRG ZNF469 TREX1 NCF1 LPIN2 GGCX CD3E BUB1 TBXAS1 EFL1 SGCG MCM4 ERAP1 CLCN7 MSH6 GNAQ COPA HAVCR2 NOTCH1 PEX12 SH3GL1 F13A1 SPINK1 IGH DOCK6 HABP2 LRRC8A TERT RPS27 RNF43 ITGB3 RARA GSS HBG2 FCGR2B TNNC1 NCF2 NLRP3 PDX1 TNFRSF13C ERCC3 WAS EVC CTLA4 MYPN CD79A BLOC1S6 CCND1 ZBTB20 TRNS1 BRCA2 AIRE NCF2 TERC CCND1 HLA-DRB1 HBB RPS24 NR1H4 KRT5 MVK ACP5 TXNRD2 DAXX NUP214 TET2 TINF2 ACAD8 MVK EOGT KRT14 DNAJC19 MTHFD1 PEX16 ND1 PIK3R1 OCRL ADAR PIK3R1 MPL PRLR TMEM127 MYH9 TCF4 GNAS HBA2 SEMA4A A4GALT FCGR2C WDR19 APPL1 RUNX1 ACTN4 C4A PSAP BMPR1A B4GALT1 NFKB1 FANCC SRC MEFV RPS17 KRT14 RIN2 VCL KIF1B GBA MVK TRNT1 PLN MMUT UBE2T KLHDC8B FGA RANBP2 GTF2H5 SPINK1 SBDS FERMT3 CYP2C9 COX15 ARPC1B SPINK5 NLRP3 COG4 FHL2 RNF168 SGCD ZBTB24 NTHL1 PEX12 GINS1 TERT HYOU1 CASR NPHP4 IRF2BP2 MMACHC FANCG SEC63 CSF3R BAP1 ERCC4 CDKN2A LRP5 PLOD1 PDE11A PLAT KLF1 TCIRG1 PARN BCR HSD3B7 COL7A1 IFNGR1 PKLR RPL15 RFXAP TRMU SLC4A4 RPS17 SDHB ASAH1 SLC7A7 GP1BA SLCO2A1 DNMT3A HLA-B ORAI1 DHFR STEAP3 FIP1L1 SLC4A1 SPTA1 CALR BAP1 LAMTOR2 PRF1 SERAC1 KCNN4 ABCC8 LCK NPM1 ITK TAL2 IFIH1 TNXB COL5A1 AMMECR1 COX20 ATP7A FANCI FAH JAK2 PHKG2 GALC TNFRSF13C SEC24C RPL31 TGFB2 ITGA2 IL2RG CCND1 NUMA1 FUCA1 ATR FLI1 APP MMP1 CA2 CACNA1D SPTB KRAS SMPD1 TUBB1 SPTA1 VHL CAPN5 RPL11 HBB-LCR GP1BA PEX14 TBX2 EPB42 GYPC SMARCB1 CORIN DOCK2 FANCA LAMB3 CD79B AMN LYST ABCB7 GNAQ DTNBP1 PDGFRA SLC30A10 GBA GBA LMAN1 GNAS HBB PROC STS FANCB FECH MMUT DBH PFKM RFT1 KRIT1 KRAS SMAD4 TACO1 AP3B1 LCAT NLRP3 GATA2 SEMA3E ATM RPL5 ADAMTS13 AMMECR1 PACS2 FASTKD2 HBB SPP1 PRF1 ATP7B GCNT2 SPTB ARHGEF1 CASR KCNE5 ALDOB CD3D CYB5R3 F13B BEST1 BCL10 PSMB4 CPT2 GCLC PTPN22 PDCD10 COX1 COL14A1 SP110 TERT NUMA1 CFTR C4A NDUFA13 PRKACA CD27 FANCC IDH2 SLC46A1 EVC2 RFT1 LPIN2 TCAP TGFB2 FOXN1 RREB1 RNU4ATAC STK11 SCN11A APC TET2 SDHA BTK PDGFRA SCO1 CD81 RET PANK2 PRKCD ATP6AP1 COX10 NLRP1 HBG2 PHGDH PTPN11 TNFSF12 KAT6B FLT1 ADA EGLN1 KRAS CLCNKB PRTN3 COL3A1 SLC39A13 FGB DNAJC19 RIT1 KIT KRT5 GP1BB LDB3 DDX41 NDUFA4 NPHP4 CLPX F13A1 RPL11 NUP214 NFKB2 CLCN7 TARS1 ND4 MYH7 GNAS TERT DLL4 CALR NDUFAF3 PLEKHM1 COL4A1 LMBRD1 THRA GBA TACO1 IRX5 ATOH7 SEC61A1 TNFSF11 SLC19A2 KLF1 IDH2 TBX1 NEUROD1 THPO PML PANK2 ANK1 GATA2 NPM1 NDUFS7 CACNA1S G6PD LAT SOS1 LYRM7 ANGPTL6 GFI1 NBN TNNI3 LARS1 APP GATA1 USB1 FAS HPRT1 TBXA2R F10 TAZ MLH1 MUC1 HPGD COL3A1 FGG GNB1 PROS1 ACD KDM6A ALG2 FBXL4 FYB1 NPC1 CPOX USP8 GLB1 CYP11B2 IL10RA ABCC9 EXTL3 TET2 JAK2 GBA FGFR2 CFI COL1A2 WRAP53 GP6 TALDO1 HBB SRD5A3 KCNJ11 PIGT ABL1 FANCE COL3A1 FANCM MAX PRKG1 IGHM RAF1 FLNA F12 CFI PGM3 CYP4F22 AAGAB IL12A PSMB8 PDHA1 TNFRSF1B PSEN2 PDGFRB PNP APOE CR2 TMEM165 LAMC2 BRAF FAT4 F8 CD19 SALL4 UROD TNFSF11 PTPN22 AKT1 SLC2A10 SGPL1 CYBA TTC37 JAK2 PSMB9 GP1BB KRT14 TERC EXT2 F13B TRAC TSR2 PFKM OCLN HBB NLRC4 FANCE LYST HBG1 TBXAS1 ABCG8 TGFB3 CYP2A6 APOB TRNW FAM111A NDE1 DCLRE1C TPM1 IL7R COL4A5 NOD2 ARFGEF2 NDUFA10 IL2RG RAG1 PIK3CA DNM2 TCF4 TERC NDUFV1 GNA14 GALT SLC2A1 STAT1 ANK1 FANCF SLC25A38 AKR1D1 WAS PGM1 IL2RA PGK1 LIPT1 ATM CRYAB STAT4 IKZF1 ATRX SLC35C1 SH2B3 MYH9 SH2D1A CCND1 VPS13A CDC42 UBR1 ADA2 SCO2 CYP26C1 NDUFA9 ASXL1 ALAS2 HLA-DRB1 C15ORF41 RPS14 GATA2 CDH23 NBN EPCAM NHP2 MMADHC CBLIF SRP54 DKC1 TPI1 RECQL4 CD28 GLB1 IRAK1 DGUOK MMUT BLOC1S3 ENG TGFBR3 ABCC6 TSR2 PTEN NCF4 NRAS PHKA2 FERMT1 MAN2B1 FLT3 SERPINF2 MMP1 PICALM PIK3CD APOA1 CP LAMB3 IVD GNE ATRX STIM1 IKBKG TERT SAMHD1 RBM8A DNMT3B PHF21A NFKB2 TMTC3 MPL RPL18 CLPB FLNA ETV6 TP63 RTEL1 OPA1 CTC1 TREX1 PROS1 STAT3 RMRP SF3B1 CFTR SERPINE1 COL4A1 DOLK SLC25A11 XRCC4 PRKCD HBB CCM2 COQ2 PIGA CFHR1 MPL LRP5 HMGCL TNFRSF4 CA2 FZD4 TERC PMM2 HTRA2 KIT RAB27A CBS PLA2G4A GUCY1A1 VKORC1 WFS1 RPS7 IL2RB COX8A MMAB ALG8 NUTM1 DIAPH1 RBM20 TP53 LEP PUF60 TRNF CYBA TBL1XR1 EP300 COX14 GNA11 F5 TF COL7A1 TINF2 RBPJ THBD ICOS CLDN1 KIF11 PEX5 BPGM PLAU LZTR1 SLC4A1 SLC46A1 PTPRC FGB RYR1 PLEC RPS28 ARVCF CLCN7 NBN MST1 CFH SLC11A2 FGG TMEM127 CD28 HAX1 MRPS7 CD8A AMACR RAF1 SDHA CHST14 JMJD1C ND5 ELANE HELLS APC FLI1 HPS5 STAT3 ADAM17 TTC37 RHAG ATP7B BLNK SHPK CYB5A BLNK FOXP1 MAT2A F7 BUB1B PEX2 GNAQ PMS2 MSH6 ACTN2 MPLKIP AIP POMP CPA1 ITGB2 BCS1L LRBA DNMT3B EFL1 VHL RPSA RUNX1 FANCD2 DES USP18 CLCN7 BRD4 XRCC4 MSH2 NPHP1 SNX10 JAK2 MAP2K1 COL17A1 ALAD AK1 APOE NDUFAF5 SMPD1 ITGA2B IDH1 CTLA4 SCN10A PEX11B SDHD GATA1 NPM1 RPS20 SLX4 USP8 PRKAR1A PROC JAK2 MPL SRD5A3 FOXP3 COL1A1 PSMB8 FGA MTR HPS4 HBA1 CSRP3 MSH6 CCBE1 OTULIN PGM3 SCN9A FANCL FLNA HLA-DRB1 COX3 FLNA TP53 RBM10 STN1 SDHD CIITA GSS WRAP53 TET2 HLA-B RAC2 COX2 DNAJC21 FAS TINF2 EPAS1 RPS29 LIG4 OSTM1 MAP1B IFT140 RPS19 SSR4 GP1BA BTNL2 SPTA1 CRIPT SDHA GDNF STAT3 ACVRL1 SPTA1 PTEN DLL4 ZBTB16 FOXRED1 GNAS ABCC6 COX4I2 RB1 RNASEH2B STAT5B NLRP3 NHP2 GATA1 G6PC3 COL7A1 LIG4 NF1 YARS2 COL1A1 AK2 RASA2 SLC35A1 MS4A1 LIG4 PUS1 NRAS APOE STOX1 RFWD3 GGCX PADI4 UROS HBA1 ANO6 RAF1 NOP10 LIPA RFXANK STXBP2 TRNT1 HLA-B HBD HBG1 NHP2 GSN PCNT VWF HOXA11 ALX4 BMPR1A NDUFS4 XK PIGL STAT4 CYB5R3 GBA F9 XYLT2 EPG5 HSPA9 TET2 SLC29A3 ABCC2 PEX3 ATP11C NAXD BRCA1 GATAD1 BMPR2 ELANE EPO CFH ITCH RET SBDS KLKB1 RPL26 HOXA11 BCR STAT1 SLC35A1 CASP10 TERT TRIP13 MYD88 GLA CYCS GP9 ACVR1 COLGALT1 HAMP PTEN CD244 TNXB RPS10 GCK SMARCAL1 COL4A2 CIITA BCL2 ZNF341 MAX PALB2 PUS1 TGFB3 LEPR RAG2 CD46 SLC27A4 IKBKG ETHE1 PDGFB LAMTOR2 RPL26 ITGA2B RAG1 CBFB BLM UMPS INHBA CASK CALR IL23R VPS13B SNX10 SLFN14 PIK3CA CTLA4 ND6 STT3B WT1 COG1 STEAP3 ADA ATP7A LMNA KCNQ1 DLST ZAP70 LOX UFD1 F2 EIF2AK3 TCF3 STAT3 RAG2 TAZ NBN EPO RPS15A NAGS TCIRG1 RYR1 SDHAF2 F13A1 FADD CXCR4 RBM8A NF2 CARD11 ATP6V1A LMNA FLT3 PEX13 RPS29 F10 CTC1 SDHB NF1 KIF1B PNPO CD70 MPL TPMT MPL FAS ICOS HBB NSD1 PLEKHM1 TFAM SH2B3 SDHC VPS33A CYP4V2 G6PC PRKAR1A THBD MPDU1 CISD2 SLC4A1 C1R RNASEH2B RPS19 ARMC5 PDE4D DPAGT1 CAPN3 CEL MYC TP53 ALDOA PLOD3 CBS FGB RAG1 CEBPA SCARB2 LBR HNF4A GPX1 UBE2A ACTA2 KRAS RAC2 UBAC2 TINF2 CD4 PDCD10 RAG2 CTNNB1 RFXAP HBB MAD2L2 PET100 PRF1 COL1A1 FKBP14 SRSF2 SARS2 ERMARD PNPO FGA FGA MMACHC MYD88 PRKCSH TET2 CTRC RTEL1 EPOR RRM2B KIF23 GATA1 TONSL JAK2 RHOH DCLRE1C ERCC6L2 MECOM EPHB4 RPL35A TBC1D24 MSN NIPBL NFKB1 NFIX JAK2 SF3B1 TYMP F2 COL5A2 DSG2 GREM1 ARF1 FAM111A RFX5 SBDS HBB RASGRP1 NOP10 GATA2 ENG SURF1 C1GALT1C1 IRAK4 HBA2 MECOM SLC19A3 MPL PEX19 AEBP1 CLPB HBA1 CBL FKBP14 LBR RRAS2 FN1 GPC1 IL2RG PSTPIP1 BMPR1A HBB KRT5 COX6B1 ENG TBCE ATP6V1E1 MFAP5 FANCF NRAS LARS2 KLF11 ADA2 GCDH SURF1 RPS7 IL12B FOXN1 IFIH1 PLOD1 SMAD4 MDM2 USB1 MYH7 LIG4 PRDM5 AGXT SAMD9 ABCD3 SCN5A PGK1 NDUFS2 CIITA SEC23B PRSS1 MSH2 SRP54 APP CLN3 XPR1 CFHR3 STX11 FGG DNASE1 PLEC SLC17A5 IL12A-AS1 THPO NABP1 TSC1 HBG1 FH FANCG PHGDH DNAJC21 TCN2 SPTB RPS26 SLC39A13 GATA1 CD3E ELANE RPS27 TCF3 SLC29A3 MYBPC3 F9 COMT SAR1B CD151 AGA ABL1 BMS1 POLG KRT1 STIM1 BCL11B PLEC SLC7A7 ITGA2B CST3 SERPINC1 MGAT2 MYSM1 TRNH SLC20A2 PEX10 IDH1 MPL ALAS2 GP1BB APP DMD SRP54 NHEJ1 TRNL1 SLC25A15 ALAS2 CP MAGT1 RAD51 TNFRSF13B PRLR TREM2 GP1BB SBDS SKIV2L VPS13A ACAD9 PRF1 TTC7A SC5D FANCB JAK3 CHIC2 DDOST PAX4 RTEL1 VHL NLRP12 TRNS1 TDP2 BRAF CAD IL7R XRCC2 CD19 FTCD CYBB RIN2 PTPN11 KIT KCNJ1 PLEC HSD3B7 SMAD4 RPL5 SOS2 BRCA2 TCF4 RRAS SERPINC1 TRNW F11 UNC13D DOLK C1QA RPL35 TSC2 KLRC4 KIF1B P2RY12 IKZF1 ADAMTS3 EPB42 DKC1 STK11 ELANE SAMD9L RPL15 NLRC4 RPS15A FASLG CREBBP GATA2 CTRC XYLT1 PPCS HBG2 SPINK1 ETHE1 C3 PRKAR1A PRDX1 KCNJ5 RPL18 FBN1 KRAS ARHGAP31 PRSS2 COA8 ECHS1 NBEAL2 FASLG INS ABCC8 TBXAS1 PTPN22 AASS TCIRG1 NEU1 VKORC1 SLC2A1 ATRX BAG3 RHAG RPL27 FAN1 CBL HK1 CTNNB1 BMPR1A CFB ERBB3 SALL4 PTPN11 PARN ITGA2 RARA FGG RNF113A HELLPAR PMM2 ABCC6 TEK ICOS TNFSF12 CHEK2 FZD4 GLRX5 MDH2 FMO3 TTC7A PRSS2 ENG PCCB TALDO1 TET2 HPS6 SLC4A1 AGK ALDOB PKLR TNFRSF13B MYC COG8 PTF1A COL1A2 RPS10 SAMD9L BCL10 HBB POT1 NDUFS2 VPS45 ABHD5 WAS PTEN TGFB1 SIK3 PEX26 BUB3 AMMECR1 HLCS RAD54B SLC4A1 DNM1L MYLK SLC2A1 WFS1 LIG4 NFKBIL1 ADAR DNASE1L3 CAP2 PLEC MPO ELN DKC1 HMOX1 SETBP1 TTN COL7A1 AP3D1 PKLR ETV6 PMS1 TCN2 FGB ATP7A TEK FIG4 F5 CFHR1 GDF2 ITGB4 AHCY CARD9 RASGRP2 HMGCL CYBB NDUFA2 RAG1 TREX1 MLH1 COL4A1 CTPS1 CDCA7 TNNT2 LMNB2 TF SDHC RAG1 PEX1 FKTN CD79A TFRC C1S PRDM16 PIEZO1 FOXP3 KIT A2ML1 CD3D PROS1 MMAA NDUFAF6 ARL6IP6 CTLA4 NSUN2 CTLA4 XIAP TRNS2 LIPA BCL6 EPB41 NDUFV2 HBA2 RHBDF2 IGLL1 FBN1 HPS1 UNC119 ARHGAP26 JAK2 RAG1 ERF SH2B3 CFHR3 PARN GALT SC5D FAS RPL27 TLR4 SF3B1 FDX2 PRKCD RPS24 LAMA3 KCNQ1 UBE2T C2 TERT SLC12A3 CD109 RHAG LAMC2 MCFD2 XIAP MPIG6B GGCX CHD7 IGH BLM SERPIND1 FH LAMA4 HADH RNASEH2C SMARCD2 B2M STING1 TGFBR1 CD36 PEX6 CD40LG ZMPSTE24 CD46 ITGB4 BRIP1 RAB27A ADA2 ABCB6 GATA1 NBEAL2 SAMHD1 MLH1 PRSS1 PMS2 ASXL1 MALT1 UROS BRIP1 FANCL TCIRG1 YARS2 ABCA1 MTRR PCCA CEP57 VWF TP53 TBX1 RPS28 KCNE1 NDUFS8 SMAD3 MLX
Burkitt lymphoma
Genes 8
RASGRP1 FAS CASP10 FAS FASLG PRKCD RHOH MYC
Chronic lymphatic leukemia
Genes 8
ADAR TREX1 IFIH1 PIK3R1 RNASEH2A SAMHD1 RNASEH2B RNASEH2C
Chronic myelogenous leukemia
Genes 9
KIT MPL ASXL1 TET2 ABL1 JAK2 THPO BCR SRSF2
Leukemia
Genes 190
ATM KRAS KIT RPS15A NF1 MPL RPL35A RPL11 RPL18 DDX41 SBDS LPP ETV6 BUB1B F13A1 DNMT3A JAK2 NUP214 FANCD2 MSH6 FANCA PIGL NRAS TCIRG1 BUB1 TET2 FLT3 TAL1 ATRX TREX1 PDGFRA SRP54 RPS29 PTPN11 CALR FANCE WIPF1 SF3B1 GATA2 GLI1 STS SH3GL1 XRCC4 MPL SH2B3 EFL1 PIGA TREM2 CBL MPL RUNX1 MPL PIGL THPO FANCG NSD1 BRD4 NSUN2 SH2B3 RARA GATA2 NPM1 CBL CHIC2 ERBB3 GFI1 TERT KIT BCR ARHGAP26 DYNC2LI1 EVC SCN10A GATA1 ELANE RNASEH2B RPS14 SH2B3 JAK2 RPL15 SBDS NRAS RPL26 RPL27 ADA2 RPS7 TYROBP F13B MSH2 BCR WAS TERC TP53 TRIP13 MYD88 NUTM1 RPS24 GNB1 TP53 DNMT3A TERT NUMA1 NUP214 RPL5 SAMD9L TET2 CFTR POT1 FANCC RPS10 EP300 EVC2 BUB1B CEBPA BRCA2 DNAJC21 CALR SCN9A LIG4 ADAR BLM TET2 JAK2 SMPD1 RNASEH2C SCN11A GATA2 BUB3 PRSS1 KIF11 BCR RPL35 TAL2 SRP54 IFIH1 ABL1 PDGFRB KRAS RNASEH2A TET2 MLLT10 SRP54 DNAJC21 DKC1 RUNX1 APC LIG4 CBFB BLM THPO CALR NBN JAK2 MLH1 RPS19 ELANE SAMD9L RPL31 PMS2 ASXL1 TSR2 MLF1 PIK3CA DNAJC21 RUNX1 GFI1 SRSF2 SETBP1 HAX1 RPS26 RPS17 FLT3 RPS27 PIK3R1 KRAS CEP57 PICALM CREBBP GATA2 CTRC MYD88 TET2 RPS28 ABL1 RB1 SPINK1 GATA1 NBN JAK2 SAMHD1
Lymphoma
Genes 133
ATM KRAS CD19 IGH DDX41 BCL10 BIRC3 FOXP1 MS4A1 TP63 RAG1 LIG4 NFKB2 MSH6 TERC RECQL4 NTHL1 WIPF1 CTC1 LYST NOP10 RASGRP1 TNFRSF1B XRCC4 PRKCD NHP2 MAGT1 TNFRSF13B IGH RMRP RUNX1 CTLA4 DCLRE1C FAS ICOS RNF43 NSUN2 XIAP IL7R CASP10 BCL6 CDKN2A ATM IL2RG RTEL1 PARN NBN KIT TNFRSF13C TCF4 ICOS TNFSF12 CHEK2 USB1 CD19 CR2 NRAS MSH2 WAS BCL10 CASP10 MYD88 COL14A1 PRKCD TNFRSF13B MYC MDM2 SH2D1A CCND1 BCL10 CFTR CD27 PGM3 TCF4 CHD7 IGH LIG4 BLM BCL2 TET2 HLA-DRB1 PRSS1 NPM1 KIF11 ITK WRAP53 RAD54B TINF2 FAS DKC1 APC CD81 LIG4 BLM CD28 DKC1 AAGAB RAG2 TNFRSF1B MLH1 TNFRSF13C DNASE1L3 NFKB1 PMS2 ASXL1 IL2RG PRF1 PTEN MALT1 RAD54L CTLA4 CD28 PNP SRSF2 TNFSF12 STAT3 POLE ADA CR2 ADA FASLG PIK3R1 TP53 CTRC ZAP70 MYD88 RB1 RMRP SPINK1 TERT KLHDC8B NBN RHOH
Monoclonal immunoglobulin M proteinemia
Genes 2
MYD88 MYD88
Multiple myeloma
Genes 3
LIG4 CCND1 GBA
Myelodysplasia
Genes 93
NAGS MPL SLX4 TET2 TERT TRIP13 DDX41 SBDS TP53 ATRX TET2 SF3B1 BUB1B TCIRG1 DNAJC21 RFWD3 BUB1 TET2 FANCL ATRX ASXL1 TET2 JAK2 SAMD9 SRP54 RPS14 PALB2 GINS1 SMARCD2 GATA2 SF3B1 BUB3 GATA2 SRP54 TET2 FANCB FANCE TET2 FANCM RFWD3 EFL1 RAD51 PIGA SRP54 DNAJC21 RAF1 DKC1 MPL RUNX1 MPL FANCD2 BRAF LIG4 FANCG RECQL4 THPO NBEAL2 CALR JAK2 TERC ERCC4 FANCI ELANE GATA2 SRP72 FANCG ASXL1 FANCC BRCA1 ERBB3 PTPN11 BRIP1 GFI1 SRSF2 HSPA9 KIT HAX1 GFI1B MAD2L2 CEP57 RPS14 FANCF SH2B3 XRCC2 RPS19 TINF2 SBDS TET2 BRCA2 RAD51C UBE2T JAK2 FANCA
Myeloproliferative disorder
Genes 14
CALR THPO PDGFRA CALR SH2B3 JAK2 GATA2 BCR ABL1 PDGFRB MPL SH2B3 GATA1 RUNX1
Pancytopenia
Genes 125
KRAS GBA SBDS TCIRG1 ACD FANCD2 JAK2 FANCA TCIRG1 SRP54 NLRC4 RFX5 TERT FANCE GBA SF3B1 GBA SBDS LRBA NOP10 LMBRD1 GATA2 HAVCR2 XRCC4 TNFSF11 EFL1 MMAA COQ2 PIGA SBDS MPL IRF2BP2 TERT XIAP TNFRSF4 PML TERC PRF1 GBA SRP72 PRKAR1A PSTPIP1 GFI1 TET2 TERT RARA GBA PRF1 TERC NAXD RFXANK NPM1 SLX4 ITCH TINF2 SBDS MPL NRAS RFXAP HOXA11 TERC PCCB MMAB TERT SP110 UBE2T SH2D1A SAMD9L TERT TINF2 MTHFD1 TBL1XR1 DHFR FARSB ADA2 CD27 RNASEH2A FANCC XIAP FIP1L1 SLC46A1 SCARB2 DNAJC21 LIG4 HLA-DRB1 STN1 GBA GATA2 CIITA TINF2 NBN WRAP53 BCOR TALDO1 ITK SRP54 NHP2 IFNG IKZF1 RAB27A SRP54 DNAJC21 DKC1 LIG4 OSTM1 NABP1 CALR ELANE SAMD9L COG6 DNAJC21 TCN2 NUMA1 IFNG MRPS7 ATR PCCA ZBTB16 IVD TET2 TCN2 STAT3 PALB2 STAT5B NHP2