SNPMiner Trials by Shray Alag


SNPMiner SNPMiner Trials (Home Page)


Report for Clinical Trial NCT02311140

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Effects of Kalydeco on Upper Airway and Paranasal Sinus Inflammation Measured by Nasal Lavage and on Symptoms

The aim of the proposed trial in assessment of effects of Kalydeco™ treatment on sinonasal involvement in CF patients with at least one mutation of G551D receiving a new therapy with the CFTR potentiator. The focus will be given on changes in epithelial lining fluid inflammatory markers from CF upper airways sampled by nasal lavage. The program is subdivided into a part A assessing inflammatory markers in NL and sinonasal symptoms longitudinally from pre-treatment to months with the new therapy. Part B will only be performed in a smaller subgroup and assess inflammatory markers in NL every second day in the first month of treatment and then every week until the end of month 3 with Kalydeco™ therapy.

NCT02311140 Inflammatory Changes in Epithelial Lining Fluid Sampled Non-invasively by Nasal Lavage in CF Patients With G551D Receiving Kalydeco
MeSH: Sinusitis Inflammation
HPO: Sinusitis

1 Interventions

Name: nasal lavage (routine diagnostic procedure in our centre), assessment of symptoms

Type: Other

Cystic Fibrosis patients with G551D mutation


Primary Outcomes

Measure: Changes in concentration of inflammatory markers

Time: 3 yrs

Time Perspective: Prospective

Cohort


There is one SNP

SNPs


1 G551D

Effects of Kalydeco on Upper Airway and Paranasal Sinus Inflammation Measured by Nasal Lavage and on Symptoms The aim of the proposed trial in assessment of effects of Kalydeco™ treatment on sinonasal involvement in CF patients with at least one mutation of G551D receiving a new therapy with the CFTR potentiator. --- G551D ---

Inclusion Criteria: - G551D and Kalydeco therapy Exclusion Criteria: - no G551D Inclusion Criteria: - G551D and Kalydeco therapy Exclusion Criteria: - no G551D Inflammatory Changes in Epithelial Lining Fluid Sampled Non-invasively by Nasal Lavage in CF Patients With G551D Receiving Kalydeco Sinusitis Inflammation null --- G551D ---

Inclusion Criteria: - G551D and Kalydeco therapy Exclusion Criteria: - no G551D Inclusion Criteria: - G551D and Kalydeco therapy Exclusion Criteria: - no G551D Inflammatory Changes in Epithelial Lining Fluid Sampled Non-invasively by Nasal Lavage in CF Patients With G551D Receiving Kalydeco Sinusitis Inflammation null --- G551D --- --- G551D ---

Inclusion Criteria: - G551D and Kalydeco therapy Exclusion Criteria: - no G551D Inclusion Criteria: - G551D and Kalydeco therapy Exclusion Criteria: - no G551D Inflammatory Changes in Epithelial Lining Fluid Sampled Non-invasively by Nasal Lavage in CF Patients With G551D Receiving Kalydeco Sinusitis Inflammation null --- G551D --- --- G551D --- --- G551D ---

Inclusion Criteria: - G551D and Kalydeco therapy Exclusion Criteria: - no G551D Inclusion Criteria: - G551D and Kalydeco therapy Exclusion Criteria: - no G551D Inflammatory Changes in Epithelial Lining Fluid Sampled Non-invasively by Nasal Lavage in CF Patients With G551D Receiving Kalydeco Sinusitis Inflammation null --- G551D --- --- G551D --- --- G551D --- --- G551D ---

Inclusion Criteria: - G551D and Kalydeco therapy Exclusion Criteria: - no G551D Inclusion Criteria: - G551D and Kalydeco therapy Exclusion Criteria: - no G551D Inflammatory Changes in Epithelial Lining Fluid Sampled Non-invasively by Nasal Lavage in CF Patients With G551D Receiving Kalydeco Sinusitis Inflammation null --- G551D --- --- G551D --- --- G551D --- --- G551D --- --- G551D ---



HPO Nodes


HPO:
Sinusitis
Genes 149
ATM DNAH9 DNAH11 BLNK CYBB SPAG1 BLNK ARMC4 CYBA DNAAF3 GAS2L2 CCDC151 BTK PSMB9 NCF1 FCGR3A CFAP300 CXCR4 CD79B ZMYND10 IL17RA CD19 RNF168 IRF8 CFAP221 RFX5 WIPF1 DNAI2 LRBA RSPH4A NME8 CCDC114 DNAAF4 TNFRSF13B CCDC65 RPGR DNAAF5 DRC1 LRRC8A ICOS TAP2 CFAP300 TAP1 FOXJ1 WAS DNAI1 DNAAF2 IL2RG IGLL1 CCNO NBN ARMC4 UNC119 RSPH1 RSPH1 TNFRSF13C CCDC39 STK36 RFXANK CTLA4 CD79A MGP CD19 CR2 DNAL1 DNAH1 ZMYND10 LRRC6 RSPH3 RSPH9 IL21R RFXAP NCF2 TAPBP DRC1 WAS CYBC1 PSMB4 HLA-DPA1 RSPH9 CCDC103 DNAAF1 PTPN22 DNAAF3 LRRC56 LRRC6 GAS8 CFAP298 CFAP298 ACP5 CCDC40 HYDIN CCDC65 BTK PGM3 NCF4 PIK3R1 USB1 DOCK8 IKBKB ADA DNAAF2 DNAAF6 GAS2L2 CIITA CCDC39 HLA-DPB1 DNAAF1 ICOS SPAG1 CCDC40 OFD1 RSPH4A CFI BTK IGHM DNAI2 RUNX2 CD79B DNAAF4 SH3KBP1 BLM DNAI1 NME8 DNAAF6 NCF4 IGSF3 TNFRSF13C PNP DNAH5 CCDC114 TTC25 ADA MGP TCF3 DNAJB13 RPGR CCDC103 PRTN3 TTC25 FMR1 SPEF2 IGHM DNAAF5 DNMT3B DNAL1 NFKB2 MCIDAS HYDIN