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Report for Clinical Trial NCT01453036

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Eradication of Helicobacter Pylori According to 23S rRNA Point Mutations Associated With Clarithromycin Resistance

1. Back ground Antibiotics resistance of Helicobacter pylori, especially to clarithromycin is one of the main causes of failure of eradication. 23S rRNA point mutation of Helicobacter pylori is associated clarithromycin resistance 2. Hypothesis If the investigators check the 23S rRNA point mutation then choose treatment regimens containing a proton pump inhibitor and combination of two antibiotics (amoxicillin and clarithromycin or metronidazole), the investigators will eradicate Helicoabacter pylori more successfully 3. Material & methods The investigators enroll patients diagnosed with peptic ulcer, endoscopically. Helicobacter pylori is documented with Urea breath test or silver staining biopsy specimen or polymerase chain reaction of biopsy specimen. Check the 23S rRNA A2142G/A2143G point mutation by polymerase chain reaction. If there is mutation, the investigators consider as resistance to clarithromycin and choose the treatment regimen containing a proton pump inhibitor, amoxicillin, metronidazole. If there is no mutation, choose the treatment regimen containing a proton pump inhibitor, amoxicillin, clarithromycin. Verify Helicobacter pylori eradication by urea breath test. Compare eradication rate with conventional treatment,proton pump inhibitor, amoxicillin, clarithromycin.

NCT01453036 Peptic Ulcer Helicobacter Pylori Infection
MeSH: Peptic Ulcer
HPO: Peptic ulcer

2 Interventions

Name: 23S rRNA point mutation test of Helicobacter pylori

Description: mutation test group>> Helicobacter pylori polymerase chain reaction kit by dual-priming oligonucleotide-based multiplex polymerase chain reaction system before eradication of Helicobacter pylori at mutation test groupConventional Conventional AOC group, Conventional AOM group >> no intervention

Type: Procedure

Mutation test group

Name: UBT test & Gastroenterology with biopsy c silver stain

Description: UBT test & Gastroenterology with biopsy c silver stain due to indentify H. pylori infection Conventional AOM group, Conventional AOC group, Mutation test group >> intervention

Type: Procedure

Conventional AOC group Conventional AOM group Mutation test group


Primary Outcomes

Description: Eradication was determined by the C13-urea breath test 6 to 8 weeks after the eradication therapy when PPIs had not been used for at least 2 weeks.

Measure: Helicobacter Pylori Eradication Rate

Time: 8 weeks

Purpose: Treatment

Allocation: Non-Randomized

Parallel Assignment


There is one SNP

SNPs


1 A2143G

Check the 23S rRNA A2142G/A2143G point mutation by polymerase chain reaction. --- A2143G ---



HPO Nodes


HPO:
Peptic ulcer
Genes 27
HPGD ARID1B GTF2I GTF2IRD1 CDKN2B SLCO2A1 BAZ1B CLIP2 CDC73 CDKN2C CISD2 ELN CISD2 CDKN1B AP2S1 RFC2 LIMK1 PLA2G4A MEN1 CDKN1A ERGIC1 CDC73 MEN1 CDKN1B WFS1 GNA11 TBL2