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Report for Clinical Trial NCT01730911

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Quick Start Insertion of Mirena and ParaGard Intrauterine Contraceptive Devices

Intrauterine devices (IUDs) are an effective form of contraception, but only about 3.4% of women in the US report using them. Women must often wait for their menses to start, or for results of screening for sexually transmitted infections (STIs), before their doctors will place IUDs for them. This is not the case with other birth control methods. Researchers know that it is safe to start oral contraceptive pills, transdermal patches or vaginal rings on the same day of a doctor's visit. In the investigators clinical practice, the investigators often place IUDs on the same day of a woman's visit, but outcomes have not been formally assessed. Currently, there are two kinds of IUDs available in the United States: the ParaGard T380A and the Mirena levonorgestrel intrauterine system (LNG-IUS). The investigators want to know if women who have IUDs placed at any time during their menstrual cycle have different experiences regarding the following, compared to those who have IUDS placed during the first 7 days of their cycle: bleeding or cramping patterns, active pelvic infections, becoming pregnant more often during that first cycle (window pregnancy). Women who come to their provider seeking an IUD for birth control will be asked to participate in this study. The investigators will ask them to keep track of their bleeding and cramping for three subsequent months to see if patterns differ according to the day in their menstrual cycle that the device was inserted. They will be randomly assigned either to record this information on paper, or to send in the information by responding to daily text messages. The investigators want to know if women who have an IUD placed at any time during the menstrual cycle have different outcomes compared to those who have IUDs placed during the first 7 days of their cycle. If the investigators have this information, the investigators can make recommendations to physicians, help counsel patients, and potentially expand access to IUDs.

NCT01730911 Bleeding Cramping Pregnancy With IUD in Place IUD Expulsion IUD Removal
MeSH: Muscle Cramp Spasm Hemorrhage
HPO: Hyperkinetic movements Muscle spasm

1 Interventions

Name: Text message

Description: Participants will receive daily text messages to report bleeding and cramping experienced, if they are randomized to this arm.

Type: Other

Mirena, text message ParaGard, text message


Primary Outcomes

Measure: Number of bleeding and cramping days

Time: 3 months

Purpose: Health Services Research

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 T380A

Currently, there are two kinds of IUDs available in the United States: the ParaGard T380A and the Mirena levonorgestrel intrauterine system (LNG-IUS). --- T380A ---



HPO Nodes


HPO:
Hyperkinetic movements
Genes 28
YME1L1 GRIN1 CACNA1E PTS PYCR2 TRAPPC11 CACNA1B NGLY1 GNAO1 NEUROD2 GCH1 SLC9A6 PRRT2 PNKD IQSEC2 PDE10A TRAPPC11 SUCLA2 ALDH5A1 ZNF142 SLC6A3 SYT1 FRRS1L NGLY1 RTTN GNE THOC2 PSAP
Muscle spasm
Genes 178
CACNA1S ACADVL GMPPB PRPH SMN2 RYR1 KY ATXN3 HSPB1 SNCA DNAJC13 PRPH DNA2 MYH7 UBQLN2 POLG2 WASHC5 VPS13C PON1 KCNA1 COL4A1 BSCL2 DNA2 SQSTM1 HADHB EPHA4 OPA3 POLG PMP22 ANG DCTN1 PON2 SOD1 SNCA BSCL2 TWNK TRNW SCN4A DGUOK GLT8D1 ATXN3 OPTN DCTN1 PRKN PFKM CHMP2B HNRNPA1 GFPT1 CFAP410 PFN1 GARS1 PYGM FKRP REEP1 MFN2 LDHA SOD1 DNAJC6 CACNA1S LRRK2 GNAS PINK1 TRAPPC11 C9ORF72 TRPM7 CPT2 TFG AMPD3 VAPB ATXN2 ATP1A1 GBA CHCHD10 FKRP PPARGC1A FLVCR1 GARS1 GFPT1 LAMP2 MPZ KCNJ18 CRPPA SLC12A3 TAF15 FUS ALG14 LAMA2 PGK1 COL4A1 TREM2 AR KCNJ1 FDX2 PHGDH GLA CAV3 FBXO38 STIM1 HINT1 FKRP DPAGT1 STX16 DMD SLC12A3 ALDH18A1 DOK7 ATXN2 TBK1 ATP6 SCN4A ALG2 UCHL1 MATR3 SLC12A1 ATXN3 DAO PGK1 CASQ1 GIGYF2 CHCHD10 SCN4A HINT1 NEFH GNAS STIM1 GNAS CAV3 ATP2A1 AR PARK7 SLC25A4 TRPM6 CCNF PSAT1 ANXA11 SLC16A1 CASR ORAI1 LRRK2 ATXN3 FIG4 TARDBP VAPB RRM2B RTN2 ABCB6 CASQ1 MAP3K20 PODXL HADHA HTRA2 GNA11 GMPPB EIF4G1 TRAPPC11 ERBB4 CHRNE GABRA3 FKTN GFPT1 POMT1 PON3 GLE1 VPS35 NEK1 SMN1 GARS1 ISCU PGAM2 ACADM CLCNKB UNC13A VCP NEFH DLD VCP AMPD1 MORC2