Patients will receive AZD9291 at a dose of 80 mg once daily. Systemic evaluation will be done by PET-CT scan after 6 weeks. In responding patients AZD9291 will be given orally 80 mg daily for 12 weeks. Non-responding patients will receive AZD9291 for the period of 6 or 12 weeks (according to the results of response assessment at each time-point).
Name: Tagrisso
Description: taking orally everyday for 6 or 12 weeks.Type: DrugTagrisso 80 mg
Description: assessed by PET-CT
Measure: Overall Response Rate as defined by RECIST 1.1 Time: 12 weeksSingle Group Assignment
There is one SNP
3. Treatment-naïve stage IIIA/B NSCLC with an activating sensitizing EGFR mutation/T790M • Uncommon sensitizing EGFR mutations are allowed. --- T790M ---
Exclusion Criteria: 1. EGFR TKI - resistant EGFR mutations (e.g., insertion in exon 20) • T790M is allowed. --- T790M ---