SNPMiner Trials by Shray Alag


SNPMiner SNPMiner Trials (Home Page)


Report for Clinical Trial NCT01385722

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Molecular Analysis of Thoracic Malignancies

A research study to learn about the biologic features of cancer development, growth, and spread. We are studying components of blood, tumor tissue, normal tissue, and other fluids, such as urine, cerebrospinal fluid, abdominal or chest fluid in patients with cancer. Our analyses of blood, tissue, and/or fluids may lead to improved diagnosis and treatment of cancer by the identification of markers that predict clinical outcome, markers that predict response to specific therapies, and the identification of targets for new therapies.

NCT01385722 Thymus Cancer Thymoma Thymic Carcinoma Lung Cancer Carcinoma, Non-Small-Cell Lung Mesothelioma
MeSH: Carcinoma Mesothelioma Carcinoma, Non-Small-Cell Lung Thymoma Thymus Neoplasms
HPO: Carcinoma Neoplasm of the thymus Non-small cell lung carcinoma Thymoma


Primary Outcomes

Measure: Collect detailed clinical information on patients with thoracic malignancies via the electronic medical record and a detailed patient questionnaire

Time: 20 years

Time Perspective: Prospective

Cohort


There is one SNP

SNPs


1 L858R

Over 90% of EGFR tyrosine kinase domain mutations associated with sensitivity to EGFR Tyrosine kinase inhibitor (TKI) therapy fall into two categories, in-frame deletions in exon 19, and the L858R point mutation in exon 21. --- L858R ---



HPO Nodes


HPO:
Carcinoma
Genes 16
POLE MSH2 DKC1 SMARCA4 NLRP1 POLD1 CDKN1B MLH1 RSPO1 FGFR3 BCL10 APC STK11 PTEN APC KIT
Neoplasm of the thymus
Genes 8
CDKN1B CDKN1B PTEN CDKN2B MEN1 CDKN2C AKT1 CDKN1A
Non-small cell lung carcinoma
Genes 3
TP53 TP53 BAP1
Thymoma
Genes 6
CDKN1B CDKN1B CDKN2B MEN1 CDKN2C CDKN1A