A randomized prospective study was done to determine whether i.v. 5-methyltetrahydrofolate vs oral folate improved survival in ESRD patients. Homocysteine, CRP, Lp(a), albumin, folates, vitamin B6 and B12 were checked. The 5-MTHF treated group was associated with lowered C reactive protein and higher survival than the folate treated group.
Name: 5-MTHF (5-methyltetrahydrofolate)
Description: 50 mg intravenous at the end of each hemodialysis sessionType: DrugA
Name: folic acid
Description: 5 mg per day of oral folic acidType: DrugB
Allocation: Randomized
Parallel Assignment
There are 2 SNPs
Gene polymorphisms analysis on C677T and A1298C loci and differences in polymorphisms distribution in both groups. --- C677T --- --- A1298C ---
Gene polymorphisms analysis on C677T and A1298C loci and differences in polymorphisms distribution in both groups. --- C677T ---