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Report for Clinical Trial NCT00975871

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Correlation of Genetic Polymorphism and Livedo Vasculitis

Livedo vasculitis is disease with recurrent courses of painful foot or ankle ulcerations, followed by healed white scars. The actual mechanism of its pathophysiology is not yet clear. It has been reported to be associated with some gene mutations, for example, factor V Leiden gene. This study is aimed to find the possible relation of these gene mutations in Taiwanese patients.

NCT00975871 Livedo Vasculitis Livedoid Vasculitis Livedoid Vasculopathy Genetic Pleomorphism Leiden Mutation
MeSH: Vasculitis
HPO: Vasculitis



Time Perspective: Prospective

Case-Only


There are 2 SNPs

SNPs


1 C677T

It has been reported to be related to factor V Leiden mutation (heterozygous) (22.2%), prothrombin G20210A gene mutation (8.3%), PAI promotor 4G/4G genotype and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in about total 30% livedo vasculitis patients. --- G20210A --- --- C677T ---


2 G20210A

It has been reported to be related to factor V Leiden mutation (heterozygous) (22.2%), prothrombin G20210A gene mutation (8.3%), PAI promotor 4G/4G genotype and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in about total 30% livedo vasculitis patients. --- G20210A ---



HPO Nodes


HPO:
Vasculitis
Genes 78
HLA-DPA1 IL12B IFIH1 TLR4 PTPN22 CASP10 CD19 MYD88 PTPN22 STAT4 CCR1 MVK PRKCD TNFRSF13B MS4A1 SLC22A4 HLA-B TREX1 FASLG ARPC1B C4A NFKB2 ADA2 CD244 OTULIN PGM3 CASP10 PTPN22 NLRP3 SCN9A LMX1B PADI4 ERAP1 WIPF1 SCN11A TNFRSF1A CIITA RASGRP1 HLA-DPB1 IL10 MEFV PRKCD KLRC4 IL10 CFI UBAC2 HLA-B FAS VPS13A C4A CD81 FAS NFKBIL1 IL12A-AS1 PGM3 IL12A IL23R TNFRSF13C NOD2 DNASE1L3 WAS NFKB1 DOCK8 PNP SAMHD1 MEFV TNFSF12 CR2 SCN10A ICOS FASLG CTLA4 TNFSF12 PRTN3 FAS FAS WAS MLX