SNPMiner Trials by Shray Alag


SNPMiner SNPMiner Trials (Home Page)


Report for Clinical Trial NCT00904150

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

A Case-control Study of the Molecular Genetics of Menstrual Migraine (Pure Menstrual and Menstrually-related Migraine)

The investigators hypothesize that genes that play a role in menstrual migraine can be identified using a well characterised migraine population and a comprehensive genome-wide association scan approach. The aim of the study is to identify genes, genetic regions, and the effect of hormones on expression profiles in women with menstrual migraine compared to a control population with no personal or first-degree family history of migraine. In this case control study, saliva samples will be taken from 300 cases and 300 controls for DNA analysis. Blood samples from 30 cases and 30 controls will be taken during the follicular phase as well as the luteal phase of the menstrual cycle for ribonucleic acid (RNA) analysis.

NCT00904150 Migraine
MeSH: Migraine Disorders
HPO: Migraine


Primary Outcomes

Description: PR PROGINS

Measure: Progesterone Receptor Gene Polymorphism PROGINS in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

Description: ESR1 G594A

Measure: Estrogen Receptor 1 G594a Polymorphism in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

Description: ESR1 C325G

Measure: Estrogen Receptor 1 C325G Polymorphism in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

Description: PgR and ESR

Measure: Menstrual Cycle Expression of PGR and ESR in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

Secondary Outcomes

Description: TNF

Measure: Tumour Necrosis Factor Genotype in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

Description: SYNE1

Measure: SYNE1 Genotype in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

Description: TNF and SYNE1

Measure: Menstrual Cycle Expression of TNF and SYNE1 in Women With Menstrual Migraine and Women Without Migraine

Time: 6 years

Time Perspective: Cross-Sectional

Case Control


There are 2 SNPs

SNPs


1 C325G

Estrogen Receptor 1 C325G Polymorphism in Women With Menstrual Migraine and Women Without Migraine. --- C325G ---

ESR1 C325G. --- C325G ---


2 G594A

ESR1 G594A. --- G594A ---



HPO Nodes


HPO:
Migraine
Genes 181
TWNK COL5A2 RPS15A GDF2 RPL35A AMACR RPL11 RPL18 SRPX2 RNASEH1 CCR1 SLC2A1 SLC1A3 GP1BA FGFR3 TREX1 ND1 OPA1 MLH1 TRNH COL4A1 PMS2 TRNS2 TRNS1 GP1BB POLG2 ACVRL1 PRRT2 KCNQ2 KCNA1 ND4 HTR1A KCNQ3 SCN8A RPS29 ERAP1 TRNK TRNL1 MSH6 ATP1A2 POLG COX2 ENG FAN1 TWNK TRNQ TRNQ GRIN2A PRRT2 SLC1A3 KRAS SMAD4 TRNS2 ND6 MSH2 NLRP3 GP9 GATA2 CACNA1A PIK3CA SLC2A1 RELA SCN8A TRNS1 FGFR2 CACNA1A APP GATA1 RPS20 TRNV TWNK CACNA1A RPL15 COX3 SMARCB1 FAS RPL26 RPL27 ADA2 RPS7 GCDH RRM2B ENG COL1A1 POLG IL12B TRNL1 PGK1 TLR4 SCN1A SLC6A19 SCN2A COX1 MYD88 PRRT2 STAT4 MVK VHL RPS24 TRNW PEX11B NFIX RPL5 TRNC HLA-B TRNF NOTCH3 ND1 RPS10 PDGFB SH2B1 PDGFRB TRNW COX3 GABRG2 NF2 NDP PGK1 GPR101 CACNA1A CYTB TNFRSF1A EPCAM CSNK1D APP TWIST1 RPL35 ESR1 SLC25A4 KLRC4 ADAMTSL1 IL10 MYORG TNF COL5A1 TGFBR2 SEMA4A DNM1L UBAC2 TWNK HLA-B PRRT2 COX2 ADA2 NOTCH3 C4A BMPR1A NOP56 EDNRA IL12A-AS1 RRM2B IL12A IL23R RPS19 ACSF3 C11ORF95 RPL31 TSR2 MLH3 ND5 NLRC4 ND6 MEFV AIP RPS26 ACVRL1 RPS17 RPS27 COX1 TREX1 ND5 COL3A1 TRNF POLG RPS28 CACNA1A FGFR3 PMS1 STIM1 SMAD3 MLX