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Report for Clinical Trial NCT03332017
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
The purpose of the study is to evaluate the efficacy, safety and tolerability and of
BGB-3111plus obinutuzumab versus obinutuzumab alone in participants with relapsed/refractory
non-Hodgkin follicular lymphoma.
Name: BGB-3111
Description: BGB-3111 will be administered as two 80-mg capsules by mouth twice a day (160 mg twice a day)Type: Drug
Arm A
Name: obinutuzumab
Description: Obinutuzumab will be administered 1,000 mg intravenously on days 1, 8, and 15 of cycle 1, then 1,000 mg on day 1 of cycles 2 to 6, then 1,000 mg every 8 weeks. 1 cycle = 28 days.Type: Drug
Arm A Arm B
Primary Outcomes
Measure: Objective response rate (ORR)
Time: up to 3 years
Secondary Outcomes
Measure: Progression free survival (PFS)
Time: up to 3 years
Measure: Duration of response (DOR)
Time: up to 3 years
Measure: Time to response (TTR)
Time: up to 3 years
Description: Safety and Tolerability
Measure: Incidence, timing, severity of treatment-emergent adverse events (TEAEs)
Time: up to 3 years
Purpose: Treatment
Allocation: Randomized
Parallel Assignment
There is one SNP
SNPs
1 P4503A
Requires ongoing treatment with a strong Cytochrome P4503A (CYP3A) inhibitor or
inducer. --- P4503A ---
HPO Nodes
HPO:Lymphoma
Genes 133
ATM KRAS CD19 IGH DDX41 BCL10 BIRC3 FOXP1 MS4A1 TP63 RAG1 LIG4 NFKB2 MSH6 TERC RECQL4 NTHL1 WIPF1 CTC1 LYST NOP10 RASGRP1 TNFRSF1B XRCC4 PRKCD NHP2 MAGT1 TNFRSF13B IGH RMRP RUNX1 CTLA4 DCLRE1C FAS ICOS RNF43 NSUN2 XIAP IL7R CASP10 BCL6 CDKN2A ATM IL2RG RTEL1 PARN NBN KIT TNFRSF13C TCF4 ICOS TNFSF12 CHEK2 USB1 CD19 CR2 NRAS MSH2 WAS BCL10 CASP10 MYD88 COL14A1 PRKCD TNFRSF13B MYC MDM2 SH2D1A CCND1 BCL10 CFTR CD27 PGM3 TCF4 CHD7 IGH LIG4 BLM BCL2 TET2 HLA-DRB1 PRSS1 NPM1 KIF11 ITK WRAP53 RAD54B TINF2 FAS DKC1 APC CD81 LIG4 BLM CD28 DKC1 AAGAB RAG2 TNFRSF1B MLH1 TNFRSF13C DNASE1L3 NFKB1 PMS2 ASXL1 IL2RG PRF1 PTEN MALT1 RAD54L CTLA4 CD28 PNP SRSF2 TNFSF12 STAT3 POLE ADA CR2 ADA FASLG PIK3R1 TP53 CTRC ZAP70 MYD88 RB1 RMRP SPINK1 TERT KLHDC8B NBN RHOH hr>Non-Hodgkin lymphoma
Genes 32
ATM FAS CASP10 CTLA4 FAS BCL10 CD28 BIRC3 FOXP1 TNFRSF1B MYC CCND1 ASXL1 ATM MALT1 CTLA4 CD28 SRSF2 KIT POLE IGH ADA TET2 FASLG PIK3R1 NTHL1 RASGRP1 TNFRSF1B PRKCD NBN RHOH IGH hr>