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Report for Clinical Trial NCT01604681

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

The Effect of Flaxseed Oil Supplementation on Biomarkers, Quality of Life and Cognitive Function in Hypertensive and Dyslipidemic Subjects With or Without the C677T and A1298C Polymorphisms in MTHFR Gene in Different Municipalities of Rio de Janeiro

The purpose of this study is to evaluate the effect of supplementation with flaxseed oil combined with a nutritional counseling in reducing cardiovascular risk factors in homocysteine , biomarkers of inflammation, oxidative stress, improving quality of life and cognitive decline in hypertensive and dyslipidemic genotyped for the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene.

NCT01604681 Hypertension Dyslipidemia
MeSH: Dyslipidemias
HPO: Abnormal circulating lipid concentration

2 Interventions

Name: Placebo

Description: 6 capsules per day, thirty minutes before lunch and dinner, eating 3 capsules (3 g) at a time.

Type: Dietary Supplement

placebo group

Name: Flaxseed Oil

Description: 6 capsules per day, thirty minutes before lunch and dinner, eating 3 capsules (3 g) at a time.

Type: Dietary Supplement

Flaxseed oil group


Primary Outcomes

Description: To evaluate the effect of nutritional counseling associated with linseed oil supplementation on biomarkers estutados according to the C677T and A1298C polymorphisms of the MTHFR gene.

Measure: Polymorphisms

Time: Up to 3 months

Secondary Outcomes

Description: To evaluate the effect of nutritional counseling associated with linseed oil supplementation on cognitive decline.

Measure: Cognitive decline

Time: Up to 3 months

Description: To evaluate the effect of nutritional counseling associated with linseed oil supplementation on Quality of life.

Measure: Quality of life

Time: Up to 3 months

Description: To evaluate the effect of nutritional counseling associated with linseed oil supplementation on biomarkers of oxidative stress.

Measure: Oxidative stress

Time: Up to 3 months

Description: To investigate the effect of supplementation of flaxseed oil combined with nutritional guidance on lipid profile, according to the consumption of saturated fat.

Measure: Lipid profile

Time: Up to 3 months

Allocation: Randomized

Parallel Assignment


There are 2 SNPs

SNPs


1 A1298C

The Effect of Flaxseed Oil Supplementation on Biomarkers, Quality of Life and Cognitive Function in Hypertensive and Dyslipidemic Subjects With or Without the C677T and A1298C Polymorphisms in MTHFR Gene in Different Municipalities of Rio de Janeiro. --- C677T --- --- A1298C ---

Supplementation With Flaxseed Oil in the State of Rio de Janeiro The purpose of this study is to evaluate the effect of supplementation with flaxseed oil combined with a nutritional counseling in reducing cardiovascular risk factors in homocysteine , biomarkers of inflammation, oxidative stress, improving quality of life and cognitive decline in hypertensive and dyslipidemic genotyped for the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene. --- C677T --- --- A1298C ---

To evaluate the effect of nutritional counseling associated with linseed oil supplementation on biomarkers estutados according to the C677T and A1298C polymorphisms of the MTHFR gene.. Cognitive decline. --- C677T --- --- A1298C ---

Our goal is to evaluate the effect of supplementation with flaxseed oil combined with nutritional counseling in reducing cardiovascular risk factors in homocysteine, biomarkers of inflammation, oxidative stress, improving quality of life and cognitive decline in hypertensive individuals dyslipidemic and genotyped for polymorphisms C677T and A1298C methylenetetrahydrofolate reductase gene (MTFHR). --- C677T --- --- A1298C ---

Will be collecting information on the socio-economic status of study participants through a structured questionnaire will be carried out assessment of food consumption - frequency of consumption and 24 hours, clinic - blood pressure, anthropometric - height, weight, waist circumference and BMI, body composition - bioelectrical impedance analysis, biochemical tests - lipid profile, blood glucose, insulin, homocysteine, serum folate concentrations in erythrocytes and, cobalamin, vitamin C, E and A, minerals - zinc, iron, copper and selenium, markers of oxidative stress and inflammatory response and molecular analysis - C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene. --- C677T --- --- A1298C ---

Our results demonstrate the effectiveness of supplementation with flaxseed oil, in reinforcing the results of nutritional counseling in reducing cardiovascular risk factors and biomarkers studied, besides adding to the knowledge about the interactions between markers of inflammation, oxidative stress with oil supplementation flaxseed and polymorphisms C677T and A1298C MTHFR gene, on which there are no reports in the literature. --- C677T --- --- A1298C ---


2 C677T

The Effect of Flaxseed Oil Supplementation on Biomarkers, Quality of Life and Cognitive Function in Hypertensive and Dyslipidemic Subjects With or Without the C677T and A1298C Polymorphisms in MTHFR Gene in Different Municipalities of Rio de Janeiro. --- C677T ---

Supplementation With Flaxseed Oil in the State of Rio de Janeiro The purpose of this study is to evaluate the effect of supplementation with flaxseed oil combined with a nutritional counseling in reducing cardiovascular risk factors in homocysteine , biomarkers of inflammation, oxidative stress, improving quality of life and cognitive decline in hypertensive and dyslipidemic genotyped for the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene. --- C677T ---

To evaluate the effect of nutritional counseling associated with linseed oil supplementation on biomarkers estutados according to the C677T and A1298C polymorphisms of the MTHFR gene.. Cognitive decline. --- C677T ---

Our goal is to evaluate the effect of supplementation with flaxseed oil combined with nutritional counseling in reducing cardiovascular risk factors in homocysteine, biomarkers of inflammation, oxidative stress, improving quality of life and cognitive decline in hypertensive individuals dyslipidemic and genotyped for polymorphisms C677T and A1298C methylenetetrahydrofolate reductase gene (MTFHR). --- C677T ---

Will be collecting information on the socio-economic status of study participants through a structured questionnaire will be carried out assessment of food consumption - frequency of consumption and 24 hours, clinic - blood pressure, anthropometric - height, weight, waist circumference and BMI, body composition - bioelectrical impedance analysis, biochemical tests - lipid profile, blood glucose, insulin, homocysteine, serum folate concentrations in erythrocytes and, cobalamin, vitamin C, E and A, minerals - zinc, iron, copper and selenium, markers of oxidative stress and inflammatory response and molecular analysis - C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene. --- C677T ---

Our results demonstrate the effectiveness of supplementation with flaxseed oil, in reinforcing the results of nutritional counseling in reducing cardiovascular risk factors and biomarkers studied, besides adding to the knowledge about the interactions between markers of inflammation, oxidative stress with oil supplementation flaxseed and polymorphisms C677T and A1298C MTHFR gene, on which there are no reports in the literature. --- C677T ---



HPO Nodes


HPO:
Abnormal circulating lipid concentration
Genes 286
CYP11A1 PEX1 LDLR UBR1 APOB BAZ1B PEX7 PNLIP CCDC115 ABCG8 CYP27A1 BSCL2 HNF1A CIDEC AGPAT2 LMNA RAI1 POU2AF1 GHR IQSEC2 RFC2 HMBS LIPE PEX12 BSCL2 ACADM MYO5A APOB SLC25A13 STXBP2 MSMO1 TRMU UBE3B NSDHL CPT1A SLC37A4 DHCR7 CEP19 EMD LMNA ACAD8 SLC25A20 NADK2 TMEM199 NSMCE2 GTF2IRD1 RAI1 TDP1 NGLY1 ABCA1 PMM2 POLD1 OCRL EBP BSCL2 TFG TNFSF15 LCAT HSD3B7 PLA2G4A DYRK1B PCSK9 DHCR24 PYGL TRNK TRNL1 NPC2 ABCC8 CTNS NADK2 LBR ACOX2 PIGH SLC7A7 CYP7A1 TMEM43 JAG1 DEAF1 LEP CLIP2 LMNA PEX5 NPC1 ELN CAV3 FHL1 PRF1 PLVAP FLCN CAVIN1 CETP SMPD1 PNPLA2 PRSS1 LEPR LRP6 APTX LPL STX11 TBL2 ALMS1 LDLRAP1 APOA5 BSCL2 DCAF17 PNPLA2 ZMPSTE24 SLC22A5 PIK3R5 SPIB RSPO1 PHKG2 SLC52A1 ABCA1 CFH PEX26 SETX SLC37A4 EPHX2 LIPC PPARG PEX13 ACADL PEX12 IL12RB1 ABCA1 SLC29A3 ACADM LMNA ANGPTL3 MMEL1 LMNA PLIN1 MTTP SAR1B CAVIN1 PEX3 PEX2 CYP19A1 TNPO3 ABCG5 DGAT1 TTPA SMPD1 CFHR1 LDLRAP1 GTF2I ACADVL HMGCL APOE FECH SGPL1 LMNB2 GPD1 PSMB9 TDP1 LMNA PEX6 NUP107 APOA2 CAV1 NUP107 AR FOS ZMPSTE24 TBXAS1 LMNA UCP2 CIDEC MEF2A PLIN1 PEX5 PPP1R17 ABCD1 CAV1 XRCC4 PEX10 PEX5 ADCY3 HAVCR2 ABCG8 CPT1A CYP27A1 APOB APOC3 LIPA LMNA PEX2 POLR3A TRNE FBN1 PEX10 PPARG XRCC4 ACAD9 LIPA LCAT SYNE1 LCAT DCAF17 SC5D AKT2 G6PC NPHS1 ACADVL ALMS1 LMNA LTC4S CETP LIMK1 PEX11B RAI1 GK APOC3 CCT5 CFHR3 TRNE PCSK9 ALB APOA5 SLC25A13 DHCR7 PSMB8 PSMB4 CPT2 LIPE APOC2 LDLR KCNJ1 SAR1B AGL CAV1 ACAD8 PEX19 CFTR HNF4A COG4 XIAP GHR OCRL LPL SLC12A1 UNC13D CYP11A1 PEX14 HADH NPHS2 POLR3A TANGO2 PEX1 PEX16 IL12A ZMPSTE24 PEX7 PHKA2 RAB27A FLII ACTN4 PHKG2 PANK2 AGPAT2 PHYH GPIHBP1 ALB PEX19 KCNJ11 ABHD5 LMNA PHKA2 GYS2 ABCA1 GLA MC4R SYNE2 LMNA SLC25A13 IRF5 PLA2G7 CTRC APOA1 EBP PPARG SLC25A13 AGL SPINK1 DLD