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Report for Clinical Trial NCT00687518

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Effects of Intravenous Injection of Erythropoietin on Hepcidin Pharmacokinetics in Healthy Volunteers

The aim of this study is to measure the variations of serum and urinary hepcidin levels following a single intravenous injection of erythropoietin in healthy volunteers. Hepcidin is a major regulator of iron homeostasis. It acts by binding on ferroportin, and limits cellular efflux of iron through enterocytes and macrophages. Anemia and hypoxia are known to modulate hepcidin synthesis. In these situations, erythropoietin synthesis is increased, so it can be postulated that erythropoietin could modulate hepcidin synthesis.

NCT00687518 Iron Metabolism Disorders
MeSH: Metabolic Diseases Iron Metabolism Disorders

2 Interventions

Name: Erythropoietin

Description: Intravenous injection of 50 U/kg of erythropoietin

Type: Drug

1

Name: Placebo

Description: Intravenous injection of equivalent volume of saline serum

Type: Drug

2


Primary Outcomes

Measure: serum hepcidin levels

Time: over 24 hours

Secondary Outcomes

Measure: urinary hepcidin levels

Time: over 24 hours

Measure: serum iron and ferritin levels

Time: over 24 hours

Purpose: Basic Science

Allocation: Randomized

Crossover Assignment


There is one SNP

SNPs


1 C282Y

Inclusion Criteria: - healthy volunteers - male aged 18 - 30 - normal routine laboratory values - normal ECG - normal iron status Exclusion Criteria: - C282Y mutation of the HFE gene - alcohol or tobacco consumption Inclusion Criteria: - healthy volunteers - male aged 18 - 30 - normal routine laboratory values - normal ECG - normal iron status Exclusion Criteria: - C282Y mutation of the HFE gene - alcohol or tobacco consumption Iron Metabolism Disorders Metabolic Diseases Iron Metabolism Disorders null --- C282Y ---

Inclusion Criteria: - healthy volunteers - male aged 18 - 30 - normal routine laboratory values - normal ECG - normal iron status Exclusion Criteria: - C282Y mutation of the HFE gene - alcohol or tobacco consumption Inclusion Criteria: - healthy volunteers - male aged 18 - 30 - normal routine laboratory values - normal ECG - normal iron status Exclusion Criteria: - C282Y mutation of the HFE gene - alcohol or tobacco consumption Iron Metabolism Disorders Metabolic Diseases Iron Metabolism Disorders null --- C282Y --- --- C282Y ---



HPO Nodes