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Report for Clinical Trial NCT03342170

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Influence of ABO Blood Group on the Risk of Complications in Alcoholic or Viral C Cirrhosis? Analysis From Two French Prospectives National Cohorts CIRRAL and CIRVIR of Patients With Alcoholic or Viral Cirrhosis Child Pugh A

The non-O blood group is a risk factor of deep vein thrombosis and recurrence of thromboembolic events, especially when associated with Factor 5 Leiden or prothrombin G20210A mutations. A recent study suggests that non-O blood group may promote portal vein thrombosis in non cirrhotic patients. In addition, in general population and chronic hepatitis C, non-O blood group combined with one or the other of the above genetic abnormalities is associated with an increased risk of liver fibrosis and accelerated fibrogenesis. The suspected mechanism could be an increased procoagulant factor VIII and an increased Willebrand plasma level, due to a low ADAMTS 13 activity, the result of which is an hypercoagulable state and a microthrombotic process. In cirrhotic patients procoagulant factors and ADAMTS 13 which are respectively increased and decreased, have be shown to be prognostic markers of hepatocellular function and portal hypertension. It has been hypothesized that the hypercoagulable state and the microthrombotic process could contribute to the worsening of the disease and enoxaparin has been shown to positively modify the prognosis of cirrhosis. The role of non-O blood group in decompensation of cirrhosis and occurrence of complications including non-tumor portal vein thrombosis has never been studied. The investigators plan a longitudinal observational study to determine the incidence of complications in alcoholic and viral cirrhosis in case of non-O blood group compared to O blood group. The aim of this study is to determine whether ABO blood group may promote complications in alcoholic or viral cirrhosis. This is an ancillary study of two national cohorts assessing natural history and hepatocellular carcinoma risk factors in alcoholic (CIRRAL) and viral (CIRVIR) cirrhosis.

NCT03342170 Alcoholic or Viral C Compensated Cirrhosis
MeSH: Liver Cirrhosis Fibrosis
HPO: Cirrhosis Hepatic fibrosis

1 Interventions

Name: G20210A prothrombin gene mutation and Factor 5 Leiden mutation

Description: blood sample

Type: Genetic

CIRRAL CIRVIR


Primary Outcomes

Description: patient follow up during 3 years

Measure: cumulated incidence of complications at 3 years

Time: from inclusion to 3 years

Time Perspective: Prospective

Cohort


There is one SNP

SNPs


1 G20210A

The non-O blood group is a risk factor of deep vein thrombosis and recurrence of thromboembolic events, especially when associated with Factor 5 Leiden or prothrombin G20210A mutations. --- G20210A ---



HPO Nodes


HPO:
Cirrhosis
Genes 164
TTC37 TMEM67 GDF2 ATP7B F5 MPV17 HJV IGF2R SLC40A1 POLG ARHGAP31 CCDC115 ATP8B1 BSCL2 HFE TREX1 TTC37 JAK2 BCS1L TFR2 AGPAT2 ACVRL1 TERC FOS POU2AF1 APOE TYMP SLC30A10 BSCL2 CTC1 NOP10 UROD CAV1 INPP5E NOTCH1 TP53 ENG NHP2 FECH DOCK6 LIPA KRT8 SKIV2L RPGRIP1L SMAD4 PPARG LIPA TFAM NGLY1 TERC RPGRIP1L AP1S1 MARS1 DCDC2 SKIV2L RTEL1 GPC1 PARN BSCL2 ALMS1 TERT KRT18 SERPINA1 GBA TNFSF15 HSD3B7 ATP7B ABCB11 SFTPC GALT GLRX5 USB1 PEX1 HFE ITCH TINF2 ALDOB IL21R AKR1D1 F5 GPR35 SLC25A13 ENG TMEM67 CYP7B1 MPI APC TERC TALDO1 CTNNB1 TERT SLC7A7 NR1H4 GBE1 HSD3B7 JAG1 CASP8 HFE BMP2 HAMP CC2D2A EOGT FARSB COG4 TERT SCARB2 ABCB4 CAVIN1 SMPD1 MUC5B RBPJ TALDO1 PIGA AXIN1 TCF4 NPM1 COG4 WRAP53 AP1B1 IL12A LBR JAK2 ASS1 TINF2 DKC1 PHKG2 NPHP3 TRMT5 DKC1 FAH SPIB PHKG2 AGPAT2 DGUOK HBB MST1 ATP6AP1 COG6 ABHD5 PHKA2 SLC40A1 PPARG PDGFRL ACVRL1 DLL4 SLC30A10 IL12RB1 AMACR KRT18 IRF5 SFTPA2 IFT43 MET PIK3CA TREX1 MMEL1 KRT8 PPARG RRM2B TERT NHP2 CC2D2A POLG TNPO3
Hepatic fibrosis
Genes 140
CSPP1 TTC37 DYNC2H1 BBS9 TMEM67 MET IFT122 DZIP1L TMEM67 SLC40A1 WDPCP ARHGAP31 ABCB4 TTC37 GPD1 WDR35 NPHP3 POU2AF1 BBS10 SDCCAG8 C8ORF37 IQCB1 DLL4 PLIN1 BBS1 WDPCP SLC25A13 CEP290 NOP10 INPP5E NOTCH1 SCYL1 PTRH2 DOCK6 TMEM67 BBS7 CC2D2A SKIV2L RPGRIP1L DCDC2 TCTN2 LIPA TMEM67 IFT172 PMM2 NPHP3 RPGRIP1L CTNNB1 AP1S1 PKHD1 WDR35 GPC1 TTC8 NEK1 B9D1 PMM2 TNFSF15 RPGRIP1 NPHP1 BBIP1 INSR FADD INVS OFD1 CCDC28B PEX1 MKS1 PNPLA6 NEK8 CC2D2A LZTFL1 INPP5E RPGRIP1L ANKS6 GPR35 NPHP4 TMEM67 CEP290 MPI TMEM231 IFT80 MPI ARL6 AGL WDR60 CEP55 ASL ALG9 CC2D2A EOGT BBS2 MKKS IFT27 GLIS3 BBS5 INSR CEP290 TRIM32 ABCD3 TRAF3IP1 TMEM107 SDCCAG8 BBS1 DOLK MKS1 RBPJ TALDO1 TCF4 IL12A NPHP1 NHP2 WDR19 TMEM67 HJV HAMP TRAF3IP1 CYP7B1 NPHP3 SPIB PHKG2 IFT140 DGUOK MST1 B9D2 PHKA2 SLC40A1 WDR34 BBS4 PKHD1 TMEM216 SCYL1 DLL4 CEP164 IL12RB1 IRF5 MMEL1 BBS12 IFT172 CC2D2A TNPO3