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Report for Clinical Trial NCT00226551

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

ß2 Adrenergic Receptor Polymorphisms and Vasodilation of Internal Mammary Artery Induced by Isoproterenol

Single nucleotide polymorphisms at codon 46 and 79 of the gene encoding for the ß2 adrenergic receptor (ß2AR) modify its pharmacological properties and may alter the response to ß2AR agonists. The goal of the present study was to evaluate the role played by the Arg16Gly and Gln27Glu polymorphisms on isoproterenol induced relaxation of internal mammary arteries segments ex-vivo. Internal mammary leftover segments were collected from 96 patients undergoing coronary artery bypass graft operation. Four rings that were prepared from each specimen were allowed to reach equilibrium with physiological Krebs solution prior to precontraction with U46619. Using the organ bath technique, cumulative dose response curve of isoproterenol was constructed and mean EC50 calculated for each patient.

NCT00226551 Coronary Disease
MeSH:Coronary Disease

1 Interventions

Name: Isoproterenol

Type: Drug


Primary Outcomes

Measure: Mean Ec50% in response to rising concentration of isoproterenol

Allocation: Non-Randomized

Single Group Assignment


There are 2 SNPs

SNPs


1 Q27E

The goal of the present study was to evaluate the role played by the Arg16Gly and Gln27Glu polymorphisms on isoproterenol induced relaxation of internal mammary arteries segments ex-vivo. --- Arg16Gly --- --- Gln27Glu ---


2 R16G

The goal of the present study was to evaluate the role played by the Arg16Gly and Gln27Glu polymorphisms on isoproterenol induced relaxation of internal mammary arteries segments ex-vivo. --- Arg16Gly ---



HPO Nodes