SNPMiner Trials by Shray Alag


SNPMiner SNPMiner Trials (Home Page)


Report for Clinical Trial NCT04278027

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Epigenetic Regulation of Brain-Derived Neurotrophic Factor (BDNF) Gene Expression According to Response to Cognitive Remediation in Schizophrenia

This study is a randomised and controlled trial that aims to investigate whether Cognitive Remediation Therapy (CRT) can modulate epigenetic mechanisms by changing methylation levels of BDNF gene in patients with Schizophrenia.

NCT04278027 Schizophrenia
MeSH:Schizophrenia
HPO:Schizophrenia

1 Interventions

Name: Cognitive Remediation Therapy

Description: "CIRCuiTS is a web-based computerised CR therapy, delivered by a therapist but supplemented with independent sessions to facilitate massed practice. It targets metacognition, particularly strategy use, in addition to providing massed practice of basic cognitive functions. The therapist facilitates motivation, metacognitive and strategy development and generalisation of learning by encouraging the participant to learn about and regulate their cognitive performance and to transfer this learning to meet real-world goals. Therapists provide additional scaffolding for CR tasks to ensure consistent successful performance. Independent sessions involve carrying out cognitive tasks allocated by the therapist to ensure scaffolded learning" (Reeder et al.2017)
Type: Behavioral
Group Labels: 1

Cognitive Remediation Therapy


Primary Outcomes

Description: Mean methylation percentage in CpG island BDNF CpG exon I: located at chr11:27743473-27744564 in the BDNF

Measure: Change in methylation at Cytosine-phosphate-Guanine (CpG) exon

Time: Baseline and after 4 months

Description: Mean methylation percentage of CpG region BDNF CpG exon IV: located at chr11:27723060-27723294 in exon IV, upstream of the start codon in exon VII

Measure: Change in methylation at CpG exon IV

Time: Baseline and after 4 months

Secondary Outcomes

Description: Total score in Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery

Measure: Change in cognition

Time: Baseline and after 4 months

Description: Total score in Positive and Negative Syndromes Scale (PANSS)

Measure: Change in Symptoms

Time: Baseline and after 4 months

Purpose: Treatment

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 V66M

It also aims to test whether BDNF valine-66-methionine (Val66Met) polymorphism influences CRT treatment outcome among people with schizophrenia. --- valine-66-methionine ---

It also aims to test whether BDNF valine-66-methionine (Val66Met) polymorphism influences CRT treatment outcome among people with schizophrenia. --- valine-66-methionine --- --- Val66Met ---



HPO Nodes


HPO: