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Report for Clinical Trial NCT02707445

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Prospective Multi-center Registry of Genotyping Related Clopidogrel in Percutaneous Coronary Intervention Patients

This study evaluated epidemiology and clinical outcome of clopidogrel related various genotyping in Korean patients who had undergone percutaneous coronary intervention as a all comer registry form.

NCT02707445 Myocardial Ischemia CLOPIDOGREL, POOR METABOLISM of (Disorder)
MeSH:Myocardial Ischemia Ischemia
HPO:Myocardial infarction

1 Interventions

Name: Clopidogrel

Description: Administration of conventional dual anti-platelet treatment (aspirin 100mg and clopidogrel 75mg daily) for minimum 3 months after percutaneous coronary intervention
Type: Drug
Group Labels: 1

GENIUS


Primary Outcomes

Measure: Myocardial infarction and Death

Time: 1 year after index procedure

Secondary Outcomes

Measure: Any death

Time: 1 year after index procedure

Measure: Cardiac death

Time: 1 year after index procedure

Measure: Myocardial infarction

Time: 1 year after index procedure

Measure: Stent thrombosis (acute, late, very late)

Time: 1 year after index procedure

Description: Revascularization of in-stent restenosis which developed in previously implanted stent on index procedure

Measure: Target lesion revascularization

Time: 1 year after index procedure

Description: Ischemic or hemorrhagic cerebral infarction diagnosed by brain MRI which developed within 1 year after index procedure

Measure: Stroke

Time: 1 year after index procedure

Measure: Bleeding complication

Time: During index procedure

Description: Value which is measured with VerifyNow that can monitor platelet inhibition of clopidogrel

Measure: PRU

Time: Within index procedure

Description: Value which is measured with VerifyNow that can monitor platelet inhibition of aspirin

Measure: ARU

Time: Within index procedure

Purpose: Diagnostic

Allocation: N/A

Single Group Assignment


There is one SNP

SNPs


1 Q192R

Genes which are known to be related with clopidogrel resistance were evaluated; (1-3) CYP 2C19 *2, *3, *17, (4) PON1 Q192R, (5) ABCB1 3435C->T, (6) P2Y12, (7) CYP 2C9 *3. --- Q192R ---



HPO Nodes


HPO: