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Report for Clinical Trial NCT00405249

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

14-Day Randomized Double-Blind Comparative Viral Kinetic Study of Elvucitabine Versus Lamivudine Once Daily to HIv-1 Subjects With M184V

The purpose of this 28 day study is to assess the viral kinetics and safety of elvucitabine.

NCT00405249 HIV Infections
MeSH:HIV Infections

1 Interventions

Name: elvucitabine

Type: Drug



Purpose: Treatment

Allocation: Randomized

Single Group Assignment


There is one SNP

SNPs


1 M184V

14-Day Randomized Double-Blind Comparative Viral Kinetic Study of Elvucitabine Versus Lamivudine Once Daily to HIv-1 Subjects With M184V. --- M184V ---

Inclusion Criteria: - HIV infected, clinically stable, adults - HIVRNA 5000 -150,000, CD4 100 - Genotypically documented M184V variant - Receiving stable ART. --- M184V ---

Exclusion Criteria: - Hep B - HIV-1 genotype for 4 protease inhibitors - HIV-1 genotype positive for 2 NNRTI mutations - Previous therapy with system myelosuppressive potential within 3 months of study start - Use of Epogen or Neupogen - History of cirrhosis - Alcohol or drug dependence - Inability to tolerate oral medication - Women who are pregnant or breast feeding Inclusion Criteria: - HIV infected, clinically stable, adults - HIVRNA 5000 -150,000, CD4 100 - Genotypically documented M184V variant - Receiving stable ART. --- M184V ---

Exclusion Criteria: - Hep B - HIV-1 genotype for 4 protease inhibitors - HIV-1 genotype positive for 2 NNRTI mutations - Previous therapy with system myelosuppressive potential within 3 months of study start - Use of Epogen or Neupogen - History of cirrhosis - Alcohol or drug dependence - Inability to tolerate oral medication - Women who are pregnant or breast feeding HIV Infections HIV Infections This is a 14 day on treat/14 day off treatment randomized, double blind viral kinetic study of elvucitabine versus lamivudine administered once daily to HIV infected subjects with a documented M184V variant. --- M184V ---



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