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Report for Clinical Trial NCT03588273

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Impact of Bariatric Surgery on the Pharmacokinetics Parameters of Amoxicillin

The objective of this study was to evaluate the impact of bariatric surgery on the pharmacokinetics of amoxicillin. Methods: This study was performed as a randomized, open-label, single-dose clinical trial, with two periods of treatment, in which obese subjects (n=8) received amoxicillin 500 mg capsule orally before and 2 months after the Roux-en-Y gastric bypass surgery. The amoxicillin plasma concentration was determined by liquid chromatography coupled to mass spectrometry (LC-MS/MS).

NCT03588273 Bariatric Surgery Candidate

1 Interventions

Name: Amoxil 500 MG Oral Capsule

Type: Drug
Group Labels: 1

Amoxil 500 mg Oral Capsule Time 0

Primary Outcomes

Description: Blood samples (6 mL) for determination of plasma concentration of amoxicillin were collected via a venous catheter into heparinized tubes at pre-dose (0 h), 0.33, 0.66, 1, 1.5, 2, 2.5, 3, 4, 6 and 8 h post-dose.

Measure: Change on the plasma concentration of amoxicillin

Time: Before and 2 months after bariatric surgery.

Purpose: Basic Science

Allocation: N/A

Single Group Assignment

There is one SNP


1 G1316A

The high pressure liquid chromatography (HPLC) system (Agilent, Germany) consisted of a LC-10AD pump, autoinjector model CTC HST PAL/ 110695 and a G1316A/DE03018295 oven. --- G1316A ---

HPO Nodes