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Report for Clinical Trial NCT01555697

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Biomarker Strategies for Medication-Enhanced Cognitive Training in Schizophrenia

Cognitive training is moderately effective at reducing symptoms and improving life function in schizophrenia patients. The present application develops a strategy for increasing the effectiveness of cognitive training through the use of pro-cognitive medications. Specific biomarkers will be studied that identify patients most sensitive to these pro-cognitive medications, to test the feasibility of using these biomarkers in a large clinical trial of medication-enhanced cognitive training in schizophrenia.

NCT01555697 Schizophrenia
MeSH:Schizophrenia
HPO:Schizophrenia

2 Interventions

Name: Memantine

Description: Each participant receives a single pill of placebo or active drug (memantine, 10 or 20 mg) and completes about 6 hours of testing in the laboratory. One week later, that participant receives a single pill of the alternate comparator and is again tested in the laboratory. Thus, in total, each participant receives one placebo pill and one active pill, separated by one week.
Type: Drug
Group Labels: 1

Memantine

Name: Placebo

Description: Each participant receives a single pill of placebo or active drug (memantine, 10 or 20 mg) and completes about 6 hours of testing in the laboratory. One week later, that participant receives a single pill of the alternate comparator and is again tested in the laboratory. Thus, in total, each participant receives one placebo pill and one active pill, separated by one week.
Type: Drug
Group Labels: 1

Placebo


Primary Outcomes

Description: Prepulse inhibition of the startle reflex

Measure: Prepulse inhibition

Time: 3 years

Secondary Outcomes

Description: MATRICS Consensus Cognitive Battery Performance

Measure: MATRICS

Time: 3 years

Purpose: Health Services Research

Allocation: Randomized

Crossover Assignment


There is one SNP

SNPs


1 V158M

PPI-enhancing effects of MEM in healthy subjects are associated with: 1) increased WM; and 2) phenotypes linked to the high activity Val158Met COMT polymorphism. --- Val158Met ---



HPO Nodes


HPO: