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Report for Clinical Trial NCT00277342

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Potential Association of a Common L-FABP Polymorphism With Lipid-induced Hepatic Insulin Resistance

The investigators hypothesise that a common A277G polymorphism of the liver fatty acid binding protein (L-FABP) gene, which leads to an amino acid exchange, may be associated with alterations of lipid-induced hepatic insulin resistance. In the present study the investigators will investigate potential differences in lipid-induced hepatic insulin resistance, and in the relation between glycogenolysis and gluconeogenesis, in healthy subjects with the A277G polymorphism vs. subjects carrying the wildtype.

NCT00277342 Wildtype Polymorphism Liver FABP
MeSH:Insulin Resistance
HPO:Insulin resistance

1 Interventions

Name: measurement of lipid-induced hepatic insulin resistance

Type: Procedure


Primary Outcomes

Measure: lipid-induced hepatic insulin resistance(WT vs.SNP L-FABP)

Measure: changes in the relation GNG to GL

Secondary Outcomes

Measure: changes in peripheral plasma glucose and lipid responses

Purpose: Diagnostic

Allocation: Randomized

Single Group Assignment


There are 2 SNPs

SNPs


1 A227G

Only one common non-synonymous polymorphism (A227G) leading to an amino-acid exchange in the exonic region of the L-FABP gene has been previously identified. --- A227G ---


2 A277G

Potential Association of a Common L-FABP Polymorphism With Lipid-induced Hepatic Insulin Resistance The investigators hypothesise that a common A277G polymorphism of the liver fatty acid binding protein (L-FABP) gene, which leads to an amino acid exchange, may be associated with alterations of lipid-induced hepatic insulin resistance. --- A277G ---

In the present study the investigators will investigate potential differences in lipid-induced hepatic insulin resistance, and in the relation between glycogenolysis and gluconeogenesis, in healthy subjects with the A277G polymorphism vs. subjects carrying the wildtype. --- A277G ---

The function of the L-FABP gene may be altered by polymorphisms in coding regions of the gene, probably leading to modifications in hepatic triglyceride accumulation and hepatic insulin resistance.We hypothesize that carriers of the A277G SNP, when compared to matched wild-type subjects, may show altered responses of hepatic glucose production upon exposure to increased peripheral fatty acid concentrations, as achieved by lipid / heparin infusions. --- A277G ---



HPO Nodes


HPO: