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Report for Clinical Trial NCT03737253

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Prospective Randomised Clinical Study on Pharmacogenetics of Gonadotropin Receptors in Relation to Pregnancy and Life Birth Rate as Well as Unwanted Side Effects Such as Ovarian Hyper Stimulation Syndrome During Assisted Reproduction.

The aim is to be able to predict the hormonal response according to gonadotropin receptor genotype and hormone type used for treatment of women undergoing in vitro fertilization or egg donation. Outcome will be measured as pregnancy success, live born babies and unwanted side effects.

NCT03737253 Female Infertility
MeSH:Infertility Infertility, Female
HPO:Female infertility Infertility

2 Interventions

Name: Follitropin alpha

Description: The objective is to measure the effect of the drug according to gonadotropin receptor genotype.
Type: Drug
Group Labels: 2

Follitropin alpha Menotropin

Name: Menotropin

Description: The objective is to measure the effect of the drug according to gonadotropin receptor genotype.
Type: Drug
Group Labels: 2

Follitropin alpha Menotropin


Primary Outcomes

Description: Association between pregnancy rate and genotype is evaluated

Measure: Pregnancy

Time: up to 12 months after treatment

Secondary Outcomes

Description: Number of eggs developed in response to drug according to genotype is measured

Measure: Number of oocytes

Time: up to 6 months after treatment

Description: Live birth rate according to genotype is analyzed

Measure: live birth

Time: up to 12 months after treatment

Other Outcomes

Description: Association between overreaction to hormonal stimulation and genotype is analysed

Measure: Ovarian hyper stimulation syndrome

Time: Up to 6 months after treatment

Description: No or poor development of eggs in response to drug is analysed, genotype taken into account

Measure: Poor response

Time: Up to 6 months after treatment

Purpose: Health Services Research

Allocation: Randomized

Parallel Assignment


There are 2 SNPs

SNPs


1 N312S

This assumption is supported by a recent study on more than 600 women undergoing in vitro fertilization, demonstrating that whereas only 10% of women with asparagine in both genes (FSHR N680S and LHR N312S) became pregnant, 40% of those with serine did (Lindgren I et al. --- N680S --- --- N312S ---


2 N680S

This assumption is supported by a recent study on more than 600 women undergoing in vitro fertilization, demonstrating that whereas only 10% of women with asparagine in both genes (FSHR N680S and LHR N312S) became pregnant, 40% of those with serine did (Lindgren I et al. --- N680S ---



HPO Nodes


HPO: