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Report for Clinical Trial NCT03577314

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Dental Health in Recurrent Miscarriage

Oral infections can trigger the production of pro-inflammatory mediators that may be risk factors for miscarriage. The investigators investigated whether oral health care patterns that may promote or alleviate oral inflammation were associated with the history of miscarriage in Turkish women.

NCT03577314 Oral Health Miscarriage
MeSH:Abortion, Spontaneous Abortion, Habitual
HPO:Spontaneous abortion

1 Interventions

Name: miscarriage

Description: (ORTHOPANTOMOGRAPH® OP300 PANORAMIC, Instrumentarium Dental, Tuusula, Finland,63 kVp, 0.8 mA, 0.5 s).
Type: Other
Group Labels: 2

healthy miscarriage


Primary Outcomes

Description: If abortion material is obtainable, it will be genetically evaluated for chromosomal abnormalities. At least 8 weeks after termination of pregnancy, karyotype analysis of both couples and thrombophilia panel ( Factor V Leiden, prothrombin gene mutation G20210A, protein S/Protein C/antithrombin deficiency and MTHFR mutations) in the study group will be requested.

Measure: recurrent miscarriage

Time: below 20th week of pregnancy

Secondary Outcomes

Description: All teeth were visually using the International Caries Detection and Assessment System (ICDAS-II). The chosen sites were recorded as: 0 = sound; = first visible sign of noncavitated lesion seen only when the tooth is dried; = visible noncavitated lesion seen when wet and dry; = microcavitation in enamel; = noncavitated lesion extending into dentine seen as an undermining shadow; = small cavitated lesion with visible dentine: less than 50% of surface; = large cavitated lesions with visible dentine in more than 50% of the surface.

Measure: Dental Examination

Time: 1 Day

Description: A single calibrated examiner measured probing depth-PD, 0: healthy bleeding calculus 3:3.5-5.5 mm 4: over 5.5 mm

Measure: Periodontal Examination

Time: 1 Day

Description: A single calibrated examiner measured clinical attachment level- CAL, 0: 0-3 mm 1:4-5 mm 2:6-8 mm 3:over 8mm 4: 9-11 mm 5: over 12 mm

Measure: Clinical attachment level

Time: 1 Day

Description: A single calibrated examiner measured plaque (Pl) 0:no plaque A film of plaque soft deposit s within the gingival pocket Abundance of soft matter within the gingival pocket

Measure: Plaque Examination

Time: 1 Day

Description: A single calibrated examiner measured gingival indices (GI) 0= Normal gingiva; Mild inflammation Moderate inflammation Severe inflammation

Measure: Gingival Examination

Time: 1 Day

Description: A single calibrated examiner measured bleeding on probing (BOP) 0: no bleeding 1: bleeding

Measure: Bleeding Examination

Time: 1 Day

Time Perspective: Prospective

Case-Control


There is one SNP

SNPs


1 G20210A

At least 8 weeks after termination of pregnancy, karyotype analysis of both couples and thrombophilia panel ( Factor V Leiden, prothrombin gene mutation G20210A, protein S/Protein C/antithrombin deficiency and MTHFR mutations) in the study group will be requested.. Dental Examination. --- G20210A ---



HPO Nodes


HPO: