SNPMiner Trials by Shray Alag

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Report for Clinical Trial NCT00592540

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Unrelated Donor Bone Marrow Transplantation for Definitive Treatment of Patients With Phosphoglycerate Kinase (PGK) Deficiency

Phosphoglycerate kinase (PGK) deficiency is a rare x-linked disorder characterized by hemolytic anemia, seizures, muscle fatigue, and progressive neurological dysfunction. The disease is caused by the deficiency of PGK, an enzyme required for ATP formation through the glycolytic pathway. PGK is an enzyme that is ubiquitous to all cells of the human body, but red blood cells, muscles, and nerve cells are most severely affected by the absence of PGK due to their reliance upon the glycolytic pathway. Mutations of the PGK gene are highly variable and result in diverse phenotypes, ranging from mild hemolytic anemia only to severe mental retardation and early death in childhood. The more severe phenotypes show progressive neurologic deterioration between infancy and adolescence. This is a 2 patient study aimed at studying the role of stem cell transplant in PGK deficiency. Because the disease is so rare, the study will be limited to the 2 sibling patients followed by our group, though it would be open to other participants who would meet inclusion/exclusion criteria if such presented to us. The objective of this study is to evaluate the feasibility and efficacy of stem cell transplants to treat patients with PGK deficiency, Amiens subtype.

NCT00592540 Phosphoglycerate Kinase (PGK) Deficiency

1 Interventions

Name: Unrelated Donor BMT

Description: Unrelated donor bone marrow transplantation has not been performed with these patients in the past
Type: Procedure
Group Labels: 1

Unrelated Donor BMT

Primary Outcomes

Measure: To evaluate the feasibility and efficacy of stem cell transplants to treat two patients with PGK deficiency, Amiens subtype.

Time: 5+ years

Purpose: Treatment

Allocation: N/A

Single Group Assignment

There is one SNP


1 D164V

This D164V mutation has been identified previously as PGK-Amiens or PGK-New York in a French and in a Chinese family respectively.3,6 --- D164V ---

HPO Nodes