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Report for Clinical Trial NCT00896727

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Prediction of Therapeutic Response Using AQUA™ Quantitative Protein Expression Analysis of ER, PgR, and HER2 of Breast Cancer Tissue Microarrays From SWOG Protocol 9313

RATIONALE: Studying the proteins expressed in tumor tissue samples in the laboratory from patients with cancer may help doctors learn more about biomarkers related to cancer. It may also help doctors predict how patients respond to treatment. PURPOSE: This laboratory study is looking at protein expression in predicting response to treatment using tumor tissue samples from women with stage I, stage II, or stage IIIA breast cancer treated on clinical trial SWOG-9313.

NCT00896727 Breast Cancer
MeSH:Breast Neoplasms
HPO:Breast carcinoma Neoplasm of the breast

4 Interventions

Name: gene expression analysis

Type: Genetic

Name: protein expression analysis

Type: Genetic

Name: fluorescent antibody technique

Type: Other

Name: laboratory biomarker analysis

Type: Other


Primary Outcomes

Description: at baseline

Measure: In-situ protein expression of estrogen receptor (ER), progesterone receptor (PR), HER-2, and p53 as measured by automated quantitative analysis (AQUA™)

Time: Retrospectively at baseline

Description: at baseline

Measure: Main effects of ER, PR, HER-2, and p53, as well as interactions to generate classes formed by clustering of biomarkers, on a large breast cancer tissue microarray to predict disease-free and overall survival

Time: Retrospectively at baseline

Time Perspective: Retrospective

Other


There is one SNP

SNPs


1 S9313A

S9313A Protein Expression Analysis of Breast Cancer Tissue Microarrays From Clinical Trial SWOG-9313 RATIONALE: Studying the proteins expressed in tumor tissue samples in the laboratory from patients with cancer may help doctors learn more about biomarkers related to cancer. --- S9313A ---



HPO Nodes


HPO: