Identification of the genetic polymorphisms that could be correlated either with a better clinical response or with a major predisposition of patients to develop tolerance and/or side effects to the treatment with morphine.
Name: morphine chlorhydrate
Description: Valuation of the rescue doses necessary to maintain NRS<4 in the first 24 hours post-surgery in the two groups of patients, A e B. Group A: homozygous patients for the more frequent allele of the polymorphism A118G of OPRM1 gene (about 80%); group B: both homozygous and heterozygous patients for the less frequent allele (about 20%).
Measure: Assessment of the rescue doses in the two groups homozygous patients for the more frequent allele of the polymorphism A118G of OPRM1 gene; group B: both homozygous and heterozygous patients for the less frequent allele Time: first 24 h after surgeryDescription: Frequency of the variants at the loci OPRM1, COMT, UGTs, ESR1, both in patients with NRS ≤4 and in those having NRS >4 at least once during 24 hours.
Measure: Variants at the loci OPRM1, COMT, UGTs, ESR1,towards median pain measure Time: during 24 h postsurgeryDescription: Frequency of the variants at the loci OPRM1, COMT, UGTs, ESR1, both in patients with NRS ≤4 and in those having NRS >4 at least once during the period between 24-48 hours postsurgery.
Measure: Variants at the loci OPRM1, COMT, UGTs, ESR1,towards median pain measure Time: period between 24 - 48 h postsurgeryDescription: Pharmacokinetic study of both morphine and its principal active and/or toxic metabolites (M3G and M6G).
Measure: Pharmacokinetics of morphine during continuous administration after surgery Time: 48 h after surgeryDescription: Detection of the possible side effects after continuous morphine administration
Measure: Detection of the possible side effects. Time: 72 h postoprativelyDescription: Detection of the association between M3G/M6G ratio and polymorphisms of UGTs and its possible side effects.
Measure: Detection of the association between M3G/M6G ratio and polymorphisms of UGTs Time: within 72 h postoperativelyCohort
There is one SNP
Assessment of the rescue doses in the two groups homozygous patients for the more frequent allele of the polymorphism A118G of OPRM1 gene; group B: both homozygous and heterozygous patients for the less frequent allele. --- A118G ---
Valuation of the rescue doses necessary to maintain NRS<4 in the first 24 hours post-surgery in the two groups of patients, A e B. Group A: homozygous patients for the more frequent allele of the polymorphism A118G of OPRM1 gene (about 80%); group B: both homozygous and heterozygous patients for the less frequent allele (about 20%).. Variants at the loci OPRM1, COMT, UGTs, ESR1,towards median pain measure. --- A118G ---
- Allergies to morphine and derivates Anesthesia Surgery Valuation of the rescue doses necessary to maintain NRS<4 in the first 24 hours post-surgery in the two groups of patients, A e B. Group A: homozygous patients for the more frequent allele of the polymorphism A118G of OPRM1 gene (about 80%); group B: both homozygous and heterozygous patients for the less frequent allele (about 20%). --- A118G ---