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Report for Clinical Trial NCT03492801

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Longitudinal Monitoring of Tumor Specific Mutations in Patients With Lung Cancer

This pilot research trial studies the collection of blood samples in monitoring tumor specific mutations in patients with non-small cell lung cancer that has spread to other places in the body or cannot be removed by surgery. Collecting blood samples may help measure the changes in lung cancer, better learn methods to track cancer in the bloodstream, and improve cancer treatments.

NCT03492801 Stage III Non-Small Cell Lung Cancer AJCC v7 Stage IIIA Non-Small Cell Lung Cancer AJCC v7 Stage IIIB Non-Small Cell Lung Cancer AJCC v7 Stage IV Non-Small Cell Lung Cancer AJCC v7
MeSH:Lung Neoplasms Carcinoma, Non-Small-Cell Lung
HPO:Neoplasm of the lung Non-small cell lung carcinoma

2 Interventions

Name: Biospecimen Collection

Description: Undergo collection of blood samples
Type: Procedure
Group Labels: 1

Ancillary-Correlative (biospecimen collection)

Name: Laboratory Biomarker Analysis

Description: Correlative studies
Type: Other
Group Labels: 1

Ancillary-Correlative (biospecimen collection)


Primary Outcomes

Description: Blood samples collected will be used to evaluate the ability of next generation sequencing (NGS) to monitor the evolution of cancer-specific mutations in patients undergoing treatment for non-small cell lung carcinoma and for whom the molecular profile of the tumor cells prior to treatment is known.

Measure: Blood sample collection for tumor specific mutations study from patients with non-small cell lung cancer

Time: Baseline to 3 years

Time Perspective: Prospective

Case-Only


There is one SNP

SNPs


1 T790M

Compare the sensitivity of digital droplet polymerase chain reaction (ddPCR) to that of NGS for detecting the appearance of EGFR T790M mutations in patients treated with an EGFR tyrosine kinase inhibitor. --- T790M ---



HPO Nodes


HPO: