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Report for Clinical Trial NCT00623220

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

A Randomized Controlled Trial on the Effectiveness of Inhaled Nitrous Oxide for Pain Relief During ROP Screening Exam in the Pre-term Infant

The primary objective of the proposed study is to show that inhaled equimolar mixture of oxygen and nitrous oxide (EMONO) will reduce pain associated with retinal exam in the preterm infant, as compared to the current standard treatment (oral sucrose and topical anaesthesia). The investigators also aim to show that EMONO can be used safely in preterm neonates undergoing retinal exam, and will not result in any increase in apnea, bradycardia, or desaturation in the 24 hours following the exam. Finally, the investigators aim to show that EMONO will keep the infant calm, and make retinal examination easier and less traumatic.

NCT00623220 Retinopathy of Prematurity
MeSH:Retinal Diseases Retinopathy of Prematurity Premature Birth
HPO:Abnormal retinal morphology Premature birth Retinopathy

2 Interventions

Name: N2O

Description: EMONO
Type: Other
Group Labels: 1

A

Name: oxygen

Description: oxygen
Type: Other
Group Labels: 1

B


Primary Outcomes

Measure: The primary objective is to show decrease of pain response in the treatment group as measured by the PIPP (Premature Infant Pain Profile) score

Time: PIPP score before, during and after eye exam

Secondary Outcomes

Measure: Heart and respiratory rate will be monitored using one of our NICU integrated monitors. Continuous pulse oximetry will be performed with a Masimo Radical pulse oximeter.

Time: during 48 hours

Purpose: Treatment

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 V29C

Heart and respiratory rate will be monitored using one of our NICU integrated monitors: Draeger Infinity Gamma XL (Draeger Medical Canada Inc, Richmond Hill, ON), or HP Agilent V29C/HP 895 (Hewlett Packard Company, Palo Alto, CA). --- V29C ---



HPO Nodes


HPO:
HP:0000479: Abnormal retinal morphology
Genes 1446
SRD5A3 CACNA1F NDUFS7 CTC1 CSPP1 RP1 NAA10 PORCN TET2 SYNJ1 FBN2 COL1A1 COL2A1 PEX1 MLX COX3 PDZD7 B9D1 XYLT2 DNM2 KRT25 MITF KCNB1 PEX11B ZNF423 PDE6H TNFRSF11A NEU1 IFT172 PRRT2 ATF6 VPS33A TRNL1 RP1 CLN6 PROM1 C8ORF37 CHRDL1 OCRL KCNJ11 CERKL DAG1 TMEM98 GM2A DSE PDCD10 CABP4 PEX10 MYO5A GCDH SERPINC1 HADHA ROM1 MAFB ATP6 TACO1 HADHA ERAP1 PRPH2 RDH5 GGCX ND4L COL11A1 CHST14 CTSA TRNK RNU4ATAC REEP6 TBX1 FLNB PEX11B ABCA4 PRPF4 ND1 TUB RHO PGK1 BBS2 POMT2 PRPH2 INS PEX2 COL4A1 ABCA4 LIPH VPS13B HFE COX2 AP3D1 FASTKD2 HSPD1 MIR140 FKTN POMK TRAPPC9 PRPH2 NYX SDCCAG8 CEP164 USH2A SBDS SNRNP200 POMGNT2 PRPF6 RPE65 GUCA1A LRP5 SDHA CNGA1 NDUFS3 TUBB CLCN2 CNNM4 CP FGF3 ND3 ARHGEF18 ACOX1 SLC24A1 PRPF3 SLC7A14 MYOC VHL COX6B1 SMPD1 NDP RPGRIP1L DNM1 CBS CDHR1 PROM1 RPGRIP1 NDUFB8 LAMA1 ADAM9 COX7B FLCN CEP41 RPL10 MYO5A TMEM107 TMEM67 MEFV FOXC1 CAV1 GNAT2 BEST1 NCAPG2 INPP5E DGCR2 CRX TMEM216 HADHA SLC45A2 TRNS1 PTEN ELOVL4 NEK1 IMPG2 COL2A1 RPGRIP1 CENPF ERCC3 POMT1 HGSNAT SCAPER SEC24C TSC1 DHDDS AP5Z1 CDK4 B3GLCT POMT1 ERCC6 POC1B BBS12 ERCC2 ACVRL1 FBN1 HCN1 TMEM67 PDE6C NRL IFT122 ZNF469 TUBGCP6 SDHA SDHB AGXT GCK TMEM107 BBIP1 IFNG B9D2 HLA-DPA1 LMNA POMGNT1 PAX2 ACVRL1 LPL CNGA1 RS1 PNPLA6 COL5A2 GNAT1 IDUA KRIT1 NDUFA12 ECHS1 B4GAT1 BBS1 CFAP410 MITF NDUFV2 PAX6 MAN2B1 ERCC3 CWC27 LRP2 SZT2 ARHGEF18 CTNNB1 SDHD IFT140 SDCCAG8 C8ORF37 MMACHC CCDC22 CTNS FZD4 PEX5 LCA5 IFT172 IFT80 RERE PDE6G PRPF31 GRM6 NDUFS2 BEST1 SLC24A1 WDR19 LARGE1 MTTP ASXL1 NOD2 ELN SMPD1 HSD11B2 LRP5 YWHAG IFT140 ND5 NDUFAF6 SDHD PEX3 CHEK2 EXOSC3 SDHA PROM1 TREX1 SEMA4A PRPH2 PEX10 ARL6 RLBP1 UBA5 SMCHD1 ABCA4 HADHB HGSNAT SALL4 HK1 GBA TELO2 PEX26 TULP1 NUS1 KIF1B PEX12 ARL6 COL9A2 PMM2 REEP6 ARV1 DGCR6 RREB1 GGCX SLC19A3 RPGRIP1L LOXL3 C1QTNF5 GNAT2 WDPCP ERCC4 WRN VHL DEAF1 BCOR SAG PEX2 POMT2 LRP5 GUCA1A ND5 PANK2 SLC38A8 PEPD STXBP1 G6PC PEX26 HLA-DRB1 TUBGCP4 PAX6 COL2A1 NPHP1 WRN CLRN1 GUCY2D GP1BB CYFIP2 COL11A1 CDKN2B RPE65 SLC19A2 PCDH15 ABCC6 MAX TMEM231 FOXE3 PEX1 CLDN19 PRF1 PRTN3 TYR PGAP1 PIGL PROM1 GNB3 GMPPB GUCA1B STUB1 XYLT1 ARL3 TTC21B AKT1 ADAM9 AIPL1 C8ORF37 CEL NDUFA10 DGCR8 GABRA2 OFD1 TRNF MYO6 TMEM107 SALL4 ACTL6B TP53 COL2A1 CTSD NDUFS1 SEMA4A CDH23 TRAK1 SMPD1 CEP290 RAB18 CLTC CEP41 STAT3 BEST1 MKS1 LETM1 PEX6 RB1 LRAT IFT172 CYTB CEP290 CDHR1 NDUFAF3 RIMS1 PRPF6 TENM3 CC2D2A FKTN CFHR1 IQCB1 FRG1 PROM1 CACNA2D4 SCO2 RDH11 TXN2 KIF5A PEX2 BAP1 BEST1 KIF11 OCA2 ND4 CDH3 TACO1 NR2E3 KRT74 KIF1B ARL2BP NDUFA9 NDUFS2 POMGNT1 GSS TRNT1 VHL CEP290 KCNJ13 RPGRIP1 EPG5 PEX16 COL18A1 BBS4 IQCB1 TMEM98 RPGR IKBKG ABCC6 CC2D2A COX20 PRPH2 COL2A1 MC1R LARGE1 KIF11 PDX1 POU3F4 SDHA NPHP1 FAM161A SDHB PEX14 CHD7 AHR RRM2B PTCH1 CYP1B1 ELMO2 USH2A BBS9 RD3 MITF GUCY2D FOXRED1 GALNT3 SH2B1 GMPPB GABRB2 AP5Z1 CYSLTR2 WHRN COL2A1 NOD2 TRIM32 APOB SDHC POMGNT1 CLIP2 ERCC8 SLC19A2 PEX5 HSD11B2 DAG1 MGMT NPHP3 POMGNT1 MKKS COL4A1 KIAA1549 CP TMEM127 HLA-B SYCE1 PRPH2 GPR179 DACT1 FAM111A MC1R CEP120 NDUFB11 COL4A1 PRSS56 CEP290 GTF2E2 NMNAT1 TMEM127 RD3 UBAC2 HNF1A CSPP1 PAX6 BBS12 RLBP1 RPGR TSC2 RNASEH1 TMEM67 IDUA IL23R MTTP CHM GNA11 ND6 KCNA2 CNNM4 NEK2 PLK4 RMRP COL4A1 PEX7 CERKL CEP290 ADGRV1 NGLY1 NEU1 WDR60 TYR NDUFA13 POMT1 BCOR TTC8 ACD P3H2 MIR204 NSD2 GNAT1 BCOR RB1 GTF2H5 TARS1 TTLL5 ATP6V1A RET VHL GPR143 PEX10 RBP4 TMEM231 SDHAF1 BMP4 PEX6 CNGB1 CNGB3 TERT TRIM32 GDF6 SDHAF2 PEX14 PEX13 MPLKIP UNC119 MKS1 RNF216 ALDH1A3 ARL6 BBS2 TULP1 CLN5 OTX2 PPP3CA TRPM1 PPP2R3C PRPF31 BBIP1 OPN1LW FOXE3 PDHA1 CNGA3 B3GALNT2 ND5 TEK TTPA POMT1 FDXR LRP2 GTF2I CRB1 COL2A1 TRNW PEX1 KLHL7 LRAT SLC12A6 SAG SCN1A BCS1L CIB2 ARL13B KCNJ11 SYNGAP1 PRPH2 ADAMTS18 TREX1 ABCA4 CLRN1 TRAF3IP1 FGFR1 TRNH COL2A1 CRB1 KLHL7 ERCC1 MFSD8 ATXN7 PEX3 PDE6A PNPLA6 ALG12 SCO1 PROM1 CASK RAB28 ARL2BP PCYT1A HPS4 TBX1 ATP6 TFAP2A AP3B2 TYR HCCS TMEM231 INPP5E GZF1 TXN2 NPHP1 PRPH2 KRT71 APOE TTC8 PEX13 ATOH7 ND4 FLVCR1 TRAF3IP1 ARL3 RPE65 ISCA1 PDX1 OPN1LW APOE TTC8 TUBGCP4 AHI1 LYST RPGRIP1 SPATA7 BBS5 PCYT1A PEX6 WWOX FAS RBP3 COL9A3 TSPAN12 AHR PCDH15 NPHP4 COL11A1 FKRP SDHAF1 RET HADH TULP1 PEX16 VPS13B LTBP2 BBS5 RLBP1 ATP6 ND1 BLOC1S3 ATP6V0A2 TRNE MAPRE2 NSMCE2 PARS2 TTLL5 POMT2 RPGR PRCD LIPT1 WWOX COL2A1 NTRK2 PEX16 PIEZO2 USH1C HNF4A PITPNM3 KLF11 WDR19 SPG11 CEP290 OAT TMEM231 GNAQ EFEMP1 CHN1 SURF1 GDNF WDR34 SEMA3E ARL6IP6 ARMC9 CHM ZNF408 MFRP NECAP1 C8ORF37 WWOX COL11A1 TERT COL2A1 PEX5 GUCY2D SPATA7 BAP1 BBS10 HGSNAT ABCC8 PEX13 GGCX CYTB HLA-A TRIM44 APPL1 HEXB GDF3 PEX6 RPGR CTSA GUCA1A CRB1 FGF12 ACTB RRM2B NOTCH3 CYP4V2 PRSS56 TUBB4B MAK PRPH2 CACNA2D4 BEST1 COL9A1 IL12A MCOLN1 FSCN2 FAM111A ERCC6 CLCNKB ND4 CRX KCNV2 DPM1 BBS2 CRB1 ROM1 LARGE1 PEX12 ENG ESS2 IDUA RP9 RNU4ATAC FGFR2 SACS CA4 MSTO1 TRNL1 KCNA2 RP9 GPIHBP1 WT1 RBP4 IL12A-AS1 ATF6 HADHA NELFA HSD17B10 SURF1 CABP4 TINF2 PEX19 FTL MKS1 GUCA1A COX10 PEX2 C12ORF57 MFRP APC GPR179 TUB RAB28 VCAN POMK IDH3B LOXL1 CSPP1 WDR19 AKT1 PAX6 ACO2 ZFYVE26 ERCC5 NDE1 ABHD12 CRX PITPNM3 ITM2B CACNA1F SAG STN1 PTEN CEP78 ND2 TK2 UFD1 KIAA0586 FBLN5 IFT74 FLNB MERTK TMEM216 CACNA1A YAP1 PGK1 SOX10 CTNS IDH3B TRNQ NDP XRCC4 NDUFB11 KIZ PAX4 JMJD1C TPP1 OAT HMCN1 CHST6 RBP3 CC2D2A RPE65 COX8A C2CD3 AP3B2 ND6 GABRA5 CFI ATF6 PTPN22 ATP6 SDHD DUX4 ND5 RPGR RTTN ABCA4 FAS AMACR ALMS1 TSC1 NDUFS2 TMEM67 PRPH2 PIGL ALDH3A2 MCOLN1 PEX19 PRCD PORCN SEMA3E PCARE PRPF3 DHDDS COX7B PEX7 CACNA1F NF2 RPGR ZNF513 NEK1 CCND1 ARL6 VHL TULP1 BEST1 SLC52A2 SLC25A11 RDH12 CACNA1F DYNC2H1 GUCA1B PDE6B MKS1 SAG GRM6 CNGA3 ASAH1 ND1 STAT4 HACE1 CTNNB1 GRN C2CD3 ERCC5 DRAM2 FKRP COG1 PDE6C ND6 FSCN2 POMT1 PLOD1 FIBP ND2 RPS6KA3 SF3B1 CLRN1 COMT IMPDH1 FBN1 ATP6 MVK PRPS1 HADHB ALDH3A2 MTFMT NAA10 MKKS SELENOI POMK ROM1 PTEN PDE6B RNF113A GUCY2D BEST1 ND2 CDKN2A SLC24A5 TRNS1 RAB3GAP2 MAPKAPK3 COX1 NDP AHI1 RXYLT1 KCNJ13 CRYAB SUMF1 RGR SACS PAX6 PEX14 ND4 CAPN5 WARS2 C8ORF37 APOC2 NMNAT1 ZNF423 FKRP SDCCAG8 NHS CNKSR2 PCNA PTPN22 RAI1 TRIM37 ELN AIPL1 TERC COX10 COX15 DNAJC21 ARV1 ABCC8 EYS CNGB3 CNGB3 TERF2IP ACTA2 DHX38 PET100 PLK4 ABCA4 CCR1 FKRP USH1C ERCC2 PDZD7 PCARE DPP6 ATP1A2 AHI1 PDE6C TRNV RP2 RLBP1 IFT140 WASHC5 CACNA1A C8ORF37 GDF6 COX14 CDH3 PANK2 NYX AARS1 BMP4 PDE6D TRPM1 LRAT RFC2 ERCC3 CLDN19 PEX12 TMEM67 PUF60 TRNN NEK2 CDH3 NDUFV1 BCS1L CCNQ KRAS IDS CACNA1F ND6 OPN1MW CTLA4 CNGB3 POMT2 PET100 EP300 FKTN PPT1 BEST1 HLA-B IFT88 XYLT2 PEX3 COX15 TRNL1 GRK1 SDHD TRNW RHO RAX2 ARSG IFT140 TBX22 EPAS1 OPA1 MICOS13 DRAM2 CEP55 NDP PHYH LRAT PMM2 BBS7 HEXA BBS2 RDH12 ATXN7 HACE1 IQCB1 TNFRSF11B MYO7A IDH3A KLRC4 CFH SUMF1 BBS9 NDUFAF1 TAF2 PEX26 CST3 POMGNT1 RPGRIP1 RHO INSR CHD7 HBB ENPP1 PRDX1 WFS1 PEX16 MERTK RDH11 MAB21L1 B4GAT1 PROM1 COA8 IFT27 LIMK1 ZFYVE26 TBL2 PAX2 UBE3B LZTFL1 RPGR HPS5 PDE6A INS AIPL1 PDE6G CEP164 PRPF4 TEAD1 TRNT1 ARL6 SLC37A4 SLC1A2 IMPG2 PMPCA PEX1 CC2D2A CEP290 GATA3 RBP3 INPP5E KIZ MDH2 ATP8 PRPF8 TOPORS RB1 COX3 TOPORS RDH12 PCYT1A MAK KIAA0586 FKTN HPS6 COL9A2 LRP5 ADAMTSL1 RLBP1 SCAPER NDUFAF2 EXOSC2 USP45 RGR NSMCE2 ACTB TMCO1 GUCY2D MMACHC CRPPA PRPF8 HIRA POMT2 PEX7 RAI1 BBS10 LRIT3 USH2A TUBGCP6 SURF1 CEP83 SMCHD1 SIX6 SLC35A2 COL18A1 BBS1 TIMP3 ZNF408 SH3BP2 ATXN2 POLG EDN3 ELOVL4 OPN1MW KRIT1 OPN1MW POC1B NR2E3 LARGE1 WDR19 PEX10 TBC1D20 KLHL7 XYLT2 CTNS IGFBP7 IFT172 SEMA4A HLA-DPB1 CNGB1 TNFRSF11B SDCCAG8 ND1 SHH RAX2 DLST PDE6G GCK MDH2 TMEM138 SMAD4 PANK2 AGBL5 CFAP410 COL11A1 C4A CDH3 INVS RDH5 CRB1 POT1 INPP5E CA4 TRNK ERCC2 WDR19 SLC45A2 CRX EYS PEX2 RIMS1 TMEM67 PIK3CA TTC21B PDE6B PDE6H RPGRIP1L LRIT3 COQ2 CFHR3 IMPG1 PROS1 TUBB RP2 MSTO1 GNAT1 LPAR6 RAI1 TRNL1 EEF1A2 MKS1 FLII RHO NDUFA9 TMEM237 NDUFS4 SLC25A15 ANO10 OFD1 AIPL1 CLN3 OPN1LW ADAR CFAP410 CHST14 TCTN2 CACNA1B RHO PRDM5 CCDC28B BBS7 SDHB GRIN2D CEP290 TBX1 TLR4 NR2E3 IFT27 ZNF513 TINF2 NF2 NDUFAF5 IQSEC2 ATP6V1A PAX6 ZNF408 ANK1 IL10 RNF113A FKRP SAR1B PEX11B ETHE1 GDF2 ALMS1 RCBTB1 COA8 MFSD8 TSC2 CDHR1 IMPG2 MORC2 SALL4 PAX6 ETHE1 RHO NPHP4 CFH OFD1 DYNC2LI1 ARVCF ND4L CRPPA MAF COX3 IMPDH1 RNU4ATAC POLR3A RS1 CEP120 COL4A1 MPDZ BCOR IFT172 ABCA4 MYD88 COL5A1 JAG1 TYR MYOC HMX1 NDUFA4 RXYLT1 ASAH1 FH TTC8 PNPLA6 LZTFL1 HHAT GNAQ NRL GLB1 NDUFA2 CLRN1 PUF60 CNGA1 FLVCR1 BBS4 DHDDS PEX26 ZEB2 BAP1 AIRE TRNS2 MLXIPL CRB1 RNF216 USP45 KLHL7 SLC24A5 NMNAT1 LAMA1 PNPLA6 RAX2 IKBKG EDNRB SEMA4A COX1 POGZ GRK1 BLK NDP GABRG2 BAZ1B SNRNP200 PRPS1 FRG1 CACNA1F SLC25A15 IL12B MAX CYP1B1 SLC7A14 NEUROD1 PEX1 GNB5 CRX SCN8A PEX5 ABCC6 RAB3GAP1 NDUFS8 WDR34 SLC13A5 WDPCP ACTG1 POMGNT2 TMEM216 USH1G CACNA2D4 SLC52A3 ADAMTSL4 RP1L1 PRPH2 GDF3 SDHB PNPLA6 HCCS C12ORF57 APC TMEM138 CCM2 PLOD1 RET SDHA DHX38 SALL1 PDE6B PANK2 IMPDH1 IFT140 IMPG2 POGZ FZD4 B3GALNT2 SALL1 FAM161A SCN3A IMPG1 CTNNA1 GTF2IRD1 PEX12 SDHD CREBBP FBLN1 ATP6V1E1 PEX19 PEX1 GUCY2D PHYH GNPTAB
Protein Mutations 0
SNP 0