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Report for Clinical Trial NCT03402048

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Randomized Phase III Multicenter Trial of Customized Chemotherapy Versus Standard of Care for1st Line Treatment of Elderly Patients With Advanced Non-Small-Cell Lung Cancer

This is a randomized phase III trial that will randomize elderly patients(70 years of age and older) who are not considered eligible for standard doublet or triplet regimens. In a 2:1 fashion, patients will be randomized to the customization arm or the standard arm, respectively. This trial will be offered to patients who are previously untreated for stage IV NSCLC. The primary objective is to evaluate if chemotherapy selection based on histology and tumoral molecular determinants ERCC1, RRM1 and TS (arm A, the experimental arm) results in superior outcome in elderly patients with untreated, advanced NSCLC compared to standard of care treatments (arm B, the standard arm).

NCT03402048 Stage IV, NSCLC Lung Neoplasms Bronchial Neoplasms Carcinoma, Bronchogenic Lung Diseases Neoplasms Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms
MeSH:Lung Neoplasms Thoracic Neoplasms Respiratory Tract Neoplasms Bronchial Neoplasms Carcinoma, Bronchogenic Lung Diseases Neoplasms Respiratory Tract Diseases
HPO:Abnormal lung morphology Bronchial neoplasm Neoplasm Neoplasm of the lung Neoplasm of the respiratory system

5 Interventions

Name: Carboplatin

Type: Drug
Group Labels: 2

control arm experimental arm

Name: Gemcitabine

Type: Drug
Group Labels: 2

control arm experimental arm

Name: Pemetrexed

Type: Drug
Group Labels: 2

control arm experimental arm

Name: Docetaxel

Type: Drug
Group Labels: 2

control arm experimental arm

Name: Vinorelbine

Type: Drug
Group Labels: 2

control arm experimental arm


Primary Outcomes

Description: primary endpoint is OS (determined from the date of randomization).Assuming an exponential survival distribution for both treatment arms and a median survival time of 8 months in the control arm we anticipate to detect an improvement of three months in OS.

Measure: Overall Survival

Time: from the date of randomization

Secondary Outcomes

Description: PFS at 6 months (determined from the date of randomization). The anticipated 6-month PFS in arm B is approximately 25% and the goal in the experimental arm is to achieve a 32% improvement to 33%.

Measure: Progression Free survival

Time: at six months determined from the date of randomization

Other Outcomes

Description: adverse events and serious adverse events as a measure of safety and tolerability

Measure: AE and SAE (according to CTCAE version 4.0)

Time: every week from the day 1 treatment until the end of treatment (up to 18 weeks)

Description: Rate of successfully conducted gene expression analysis in patients that have signed the informed consent document

Measure: Rate of successfully conducted gene expression analysis in patients that have signed the informed consent document

Time: up to10 business days of submission of the tumor specimen

Purpose: Treatment

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 T790M

T790M and D770. --- T790M ---



HPO Nodes


HPO:
HP:0002088: Abnormal lung morphology
Genes 1217
GATA6 COL13A1 DNAI1 EPG5 CSPP1 ABCA12 IL2RG PORCN TGFB2 COL1A1 SOX11 IL17RC PEX1 SLC12A6 CSF2RA TCF4 NAA10 TCTN3 INSR GAS8 TTC37 SERPINF2 BRAF DOCK6 RBPJ NOD2 CLEC7A PSAP VPS33A CTRC ATM TGFB1 BCL10 BAP1 CCDC39 STN1 CD8A OCRL DNAH11 CHD7 TINF2 FOXP3 ERCC6 RANBP2 CR2 C11ORF95 PIEZO2 LACC1 DSE SETBP1 ZMPSTE24 CD3D MALT1 ADGRG6 PLP1 TINF2 SPAG1 TAP2 AGA ERAP1 IL7R CFI RUNX2 LAT DNAAF4 MAP3K8 IL17RA CHST14 ADA DNASE1L3 DNAI2 DNAH5 FOXP1 TBX1 PIEZO1 DNAH1 NKX2-5 ELP1 DCLRE1C MTHFD1 LOX TSC2 FGFR3 SOS1 IRF8 CHAMP1 EFEMP2 WDR35 CCDC39 PIK3CD HABP2 SDCCAG8 PRKN CD81 TNFSF12 ARMC4 NCF2 SMN1 RMRP TBC1D23 CHRNA1 DSG1 GDF1 NKX2-1 POLR3H SMPD1 WDR60 ATP5F1A UBE2A GLE1 COL2A1 FLCN EIF2AK4 ACTA1 RPL10 IPW MYO5A MEFV NHP2 RYR1 PIGN DGCR2 NFKB1 CCBE1 DNAH11 FCGR2B SLC26A2 FBLN5 RAG1 SOX4 PTEN PTPN11 ARMC4 DCLRE1C PSAT1 STAT3 SERPINF2 STAT3 STAT3 PARN SEC24C TSC1 RAB3GAP2 GLI3 C1R GBA ALB ADAMTS3 PIGN UMPS HLA-DRB1 LEPR SLCO2A1 BLM ACVRL1 THOC2 MMP21 CARD11 CFTR USP9X DNMT3B COL6A1 TNFSF11 FAM20C RYR1 PPP2R1B PEPD HLA-DPA1 MUSK LMNA GATA6 FBLN5 LMOD3 DIS3L2 SNORD115-1 SCNN1G GNPTAB COL5A2 KIAA0319L CXCR4 IDUA CCR6 BMP2 SNX10 MED25 CFAP410 BCOR LTBP4 STRA6 TERT EDARADD POLE FOXF1 STAT1 LIPN DRC1 VPS13A NFKB1 STK36 PTPN11 CCDC22 SLC1A4 SULT2B1 PPP1CB TAP1 IFT80 CFAP298 ZBTB24 GATA4 PIK3R1 DNAH5 GLI1 TGFB3 HPS1 DNASE1 WDR19 CEP55 ELN SMPD1 ICOS DCTN4 NUMA1 DKC1 LIG4 SMAD4 FBLN5 ACADVL PRPS1 BCL6 GPC3 AGRN RIPK1 FMO3 SNAP25 CSF2RA MUSK MAGEL2 HGSNAT STAT5B DNAAF5 GBA TTC25 CEP57 RAB27A FGF20 SLC2A10 PMM2 DGCR6 RREB1 ASAH1 CCR6 LFNG SLC35A1 IKBKB PGM3 CCDC40 BICC1 EPHB4 PEPD NSDHL MCM4 COG4 SPINK5 HLA-DRB1 WRN BMP15 KCNJ6 GP1BB GLI3 STING1 GPC3 NABP1 RARB ARHGAP31 MAPK1 ERBB2 B2M POLA1 NBN KRAS CYBC1 CFB STAT3 SP110 MCIDAS PRTN3 EOGT IL2RB MEFV MKKS PIGL ATM TERT HOXD13 ENG CHAT DICER1 DGCR8 PKD1L1 MIF FRAS1 DNAJB13 TERT ZMYND10 MKRN3-AS1 TPM2 CD247 SCNN1A COL3A1 TRAF3IP2 SMPD1 MITF RSPH4A FLI1 COLQ LETM1 NFE2L2 ITCH LPIN2 TBCE VAMP1 TPP2 PIK3CA ZBTB24 ZAP70 CD3G CASP8 NR2F2 H19 OSTM1 COPA MESP2 PKHD1 BNC1 PRKAR1A CTCF RBM10 GLI3 GAA PRKAG2 SLC46A1 CHRM3 MYSM1 DNAI2 SLC29A3 CD3E SPAG1 RELA COL11A2 PML TNFRSF13C RSPH3 SCNN1G SFTPA2 SH3KBP1 CD79B SRP54 SMAD3 WNT4 LMNA CHRNG EPG5 KITLG BACH2 UBB SPIDR MAP3K20 FUZ GREB1L GATA6 TERT GSN KIF11 DHCR24 RFX5 IKBKB LEPR KEAP1 TERC EDNRB CRTAP BCL2 TRPS1 STAT6 SLC35A1 TERC CHRNG INVS COG6 CASP8 CARD11 DNAAF4 RRAS CLIP2 USB1 PYROXD1 FSHR PARN LYST RPL10 WDR60 RFXAP TCF3 PSMC3IP MECP2 IGH CTSC HLA-B TAPBP NOTCH2 GRIP1 GNS DLL3 CEP120 CBL SCNN1B GTF2E2 PARN GPKOW ATP11A TMEM260 TNFRSF13C CEP120 IL21R RFXANK CAV1 TBC1D24 SLC25A24 UBAC2 DHCR7 SGSH GATA4 PNP NFIX USB1 TSC2 TRIP13 IDUA IL23R RFXAP ADA RAG2 DRC1 ADNP NGLY1 WDR60 FLNA POU6F2 BCOR IL2RG NCF1 ROR2 SCN9A SCNN1A TGFB2 NSD2 INTU GTF2H5 SON MYH11 TARS1 LIFR BRAF RET OFD1 ARHGAP31 NOTCH2 SOX18 CTLA4 HELLS ZMYND10 NDN EFEMP2 ALOXE3 NFKBIA PLEC SFTPC TRIP13 MPLKIP RAG1 MYLK IGH USP9X PIGN XIAP NXN TBX5 RASGRP1 NHLRC2 ITGA8 ACTA1 DLL4 ATP6V1E1 TNFRSF11A DSP PCNT CD79B HLA-B GTF2I SMARCD2 EMG1 IL2RA PTPN22 IRF5 BGN ARID1B RSPH9 SAMD9 GUSB BTNL2 TNFRSF13B CYBA DKC1 KIAA0556 ALG12 PTH1R SLC26A2 GPR35 NUP107 HPS4 TBX1 CR2 TRPV4 KRAS PRKCD SLC11A1 EGFR NSMCE3 PLG UNG SGCG RAPSN DNAAF6 RPS15A APOE LYST ACTA2 SNRPN MESP2 TCIRG1 TBC1D24 TIMM8A RAG2 MUC5B IL17F NPAP1 HYDIN SERPINA1 IRF5 FAS CIITA KPTN CACNA1C PEX13 PLCG2 GATA6 COL6A2 DICER1 CTC1 LRRC6 SFTPB FADD TTC7A RNF168 FARSB HYLS1 NPHP3 IFNGR1 GAS8 CFTR SLC34A2 FLCN ALG9 AGTR1 WDR19 TRPV3 IGLL1 CRKL TMEM94 SLC26A2 CLPB FREM2 MYOD1 WDR34 SCNN1B CCN2 PRSS1 TBX6 TSC1 KLHL40 DDR2 CCDC103 MEFV PDGFRA IL2RG NCF4 WT1 RYR1 CACNA1B DYNC2H1 POLR3A DNAAF2 TRAIP CLCA4 JAK3 OFD1 IGHM NECTIN1 IER3IP1 TNFRSF1B DCLRE1C LGI4 BCR NOTCH3 SCARB2 EVC2 IL12A LRRC56 WT1 FASLG RSPO2 PWRN1 HSPG2 RAG2 BUB1 NKX2-1 ESS2 RNU4ATAC IRAK1 ELN MST1 HYDIN SLC2A10 RAF1 TGFBR2 IL12A-AS1 MRPS22 IRAK4 MYH7 DNAH9 NELFA TNFSF12 MYH3 GPC4 SMAD4 TINF2 GRHL3 DOK7 POLA1 ATP6V0A2 TRIM28 LCK DNAI1 SMARCA4 ORC6 CSPP1 MASP2 AKT1 BMPR2 SLC5A7 RSPH3 NAB2 CRELD1 TGFBR2 NIPAL4 LZTR1 G6PC3 CCNO DVL3 FAM13A SFTPC SLC52A3 UFD1 NHP2 EPM2A SCNN1A KIAA0586 MYSM1 RIT1 UNC119 CCDC65 RAG1 ARID2 LRBA FLNB B3GLCT FGFR1 CDCA7 GDF1 FLNA DCLRE1C DHCR24 RAG1 TPM3 SERPINH1 BRCA2 HELLPAR NFKB2 FBN1 NOP10 SFTPA2 FGFR3 JMJD1C RAF1 CD46 RAG2 FAT4 MBTPS2 FCGR2A PHGDH SNORD116-1 WAS SLC18A3 CFTR KDM6A TGFBR1 ICOS SLC25A22 RPGR HLA-DRB1 NCF1 ARSB MKS1 NME8 CITED2 EWSR1 ALMS1 HES7 TSC1 INHBA CR2 IRF1 GRIP1 NEB GFI1 SERPINA1 ARID1A TAF1 NPHP3 HACD1 RNF125 EVC LAMTOR2 SMARCB1 NEK1 CCND1 VHL GLA IDUA CDC42 TERT LAMB2 WDR34 CCDC151 CYP2A6 FOXE1 LEP TECPR2 RSPH4A SPECC1L BIRC3 DYNC2H1 ABL1 PRKDC GLB1 IRF2BP2 TYK2 TCIRG1 STAT4 LRRC56 CFTR TNFRSF13B FRAS1 CORO1A STK11 DNAAF6 IL1RN NRAS PHGDH FCGR3A ASCC1 BTK GMNN ETFA ABCA12 RAC1 COMT NAA10 ACP5 FBN1 RNF168 CD19 GBA LAMA2 NAA10 NFKB2 WAS NFKB2 AK2 MGP SOX10 PTEN GBA RNF113A DNAJB13 FAT4 BLM INPPL1 TNFRSF1A FADD RPGR DNAL1 CFAP298 GATA2 NUP88 BTK REST ZBTB16 FUCA1 DNAAF1 CSF2RB AGGF1 RAG1 ZMPSTE24 GAS2L2 FANCB PTPN22 INPPL1 ALPL MGP HPGD C1QA ELN SLC25A1 DNAAF3 RAG2 TGFB1 FCN3 CAV1 RSPH9 CYBB FANCB BUB3 FLCN GPC6 SMARCE1 ELN COL6A3 DYNC2LI1 AICDA CCN2 ELANE MEFV TERC CCR1 PAX3 CCDC103 ERCC2 KAT6B TRIP11 HLA-DRB1 ITGA8 FASLG KRAS PAX6 CD3E CD19 SMARCC2 WASHC5 TAPT1 SLC18A3 HLA-DRB1 WRAP53 CEP57 MANBA DNAAF5 RFC2 SMAD3 ERCC3 WNT4 CD3D WIPF1 MS4A1 TERC BCL11B CFTR TGFB1 SHROOM4 BLNK CCNQ IL7R MYL2 RHOH CTLA4 RARA RARB RIPK4 CCDC40 EP300 NEK9 IFIH1 SOX18 FLCN SCN10A KIF1A GNPTAB CRELD1 SCNN1B JAK3 IFT140 DOCK8 MBTPS2 ZFPM2 SPINK1 HLA-DRB1 PRKCD ACTA1 NGLY1 MARS1 FOXE3 CCNO FOXC2 RSPH1 KLRC4 PIGT NPM1 SAMD9L MYBPC3 LAMTOR2 ELN TK2 GUSB CARMIL2 ETFDH NRAS LRRC8A ARID1B SELENON LIMK1 FSHR FIP1L1 TBL2 RIT1 ACE RELB SDR9C7 NADK2 PERP SFTPC CHRND AARS2 SLC22A18 ITPR1 TBL1XR1 IL2RG CDC45 ALDH18A1 ICOS STRA6 FCGR2A MARS1 AFF4 KIAA0586 WNT3 IL7R RASA2 RTEL1 HPS6 HERC2 DONSON ERF TP53 IL17RA SCNN1G CLCN7 SCN11A SFTPB WT1 HIRA DPM2 NCF2 TP53 AFF4 EXOSC9 CCBE1 TRIP4 MYH3 NEK8 ELANE NME8 SLC35C1 DNAAF1 DPF2 KMT2D RIPPLY2 CD79A WT1 CCDC114 NBN BLNK TIRAP PCGF2 AGT COL2A1 PLVAP FAS ADAMTS2 DHCR7 DNAAF2 BMPER BUB1B IFT172 RSPH1 CTLA4 HLA-DPB1 CD81 PGM3 NOTCH1 ELN ADA EGFR RLIM NCF4 RB1 STAT1 FLNB CCDC114 CFI RFXANK RSPO2 MSN C4A TNFRSF13B COQ7 MINPP1 PTPN22 CD28 CIITA GALNS NR5A1 DPP9 CC2D2A DNMT3B TTC21B ITGA3 BMPR2 CFAP300 STX1A EHMT1 ITGA7 MFAP5 BTK MYO9A TTC25 SPEF2 TNFRSF13C MKRN3 MAT2A SKIV2L ZNHIT3 SOS2 SFTPA1 CXCR4 PIK3R1 RRAS2 RTEL1 RTEL1 COL3A1 CHST14 TSC1 TRIP11 CD55 FOXJ1 SLC7A7 TBX1 CYTB TLR4 SLC26A2 CYP4F22 COG4 AP3D1 ITCH MCTP2 CD79A GAS2L2 IL10 GLDN NOTCH3 ALOX12B RAG1 ALMS1 RCBTB1 GBA TFRC TSC2 CASP10 NKX2-5 PNP DYNC2LI1 TRIM28 STAT4 ARVCF SH2D1A IL21 ZAP70 PDGFRB RNU4ATAC DNAAF3 P4HTM KLHL41 CCNQ AGA BCOR MYD88 COL5A1 ABCA3 JAG1 TREX1 IGLL1 GLE1 IFT81 LTBP3 ASAH1 NPM1 IKZF1 DICER1 SLC7A7 CYBA HFE CBL RFX5 MS4A1 WNT3 JAGN1 PUF60 ZEB2 NAGLU BTNL2 FAM111B CFAP221 MLXIPL HRAS COL13A1 WDR35 SIK1 TRIP4 PWAR1 ECM1 LMNA TGM1 COL11A2 IRAK4 PRKG1 SELENON FGF20 CD19 IKBKG TGFBR1 DLL3 ELP1 IFT80 BAZ1B CTLA4 REN CHRNG ABCA3 ZNF341 WDR34 EXTL3 KAT6B TERT XIAP MYRF SPP1 CSF2RB CYBB PIK3R1 CCND1 NOP10 MUC5B FBN1 PRSS2 PLOD1 SYT2 KAT6B IGHM PANK2 IFT43 MRAS FAS CFH PTPRC MESP2 FOXP1 FLNA TBCD LBR VPS33A SMN1 IL6 NIPBL LEP NHLRC1 CCDC151 DOCK8 LRRC6 GTF2IRD1 SNAI2 CREBBP AP3B1 ETFB VANGL1 LMNA PRKAR1A A2ML1 CDT1 CCDC65
HP:0002664: Neoplasm
Genes 1489
WHCR ATP7A PHOX2B KRT17 IL2RG HMGA2 PORCN KRAS TET2 IDH2 FLT3 ERCC4 AR BRCA1 BRCA2 GATA1 TCF4 TCTN3 GPR101 SMAD7 KRT6B PIK3CA KCNJ10 MAP2K2 REST TTC37 MC2R TRPS1 SIX6 ALX4 PIK3CA BRAF TP53 STK11 TSR2 EXT2 EDN1 RNF43 TRNL1 ATM SDHC EXT1 BCL10 BAP1 NF1 OCRL TP53 CHD7 TINF2 ERCC6 NF1 MAFA PMS2 ASXL1 PHOX2B CTNNB1 CR2 RET TCTN3 C11ORF95 PTPN3 PIEZO2 ABCB11 SETBP1 PDCD10 LRP5 LMOD1 MALT1 ASXL1 LZTR1 TINF2 RAD51C RECQL4 MAP2K1 FOXO1 PTCH2 RPS20 FLI1 BMPR1A SMARCAD1 BMPR1A MAP3K8 DNASE1L3 SUFU TP53 FOXP1 PTCH1 PDGFRB ND1 PIK3CA ZSWIM6 SETD2 INS NRAS HBB MEN1 AIP CLCNKB RPS10 HFE COX2 TSC2 DHH CTRC MEN1 EYA1 BRCA1 GINS1 MSH3 GLI2 TRNS1 HABP2 SSX1 SUFU PRKN CD81 TNFSF12 MYH11 KIT VEGFC WWOX H19 SDHD FGF3 TNFRSF1B RMRP XRCC2 HRAS MTM1 EPHB2 PLCD1 NBN CDKN1B TUBB RECQL4 EDNRB VHL ACAN MSH6 CDKN2B DCC TJP2 HRAS CDKN2A VHL REST NKX2-1 ANTXR1 RPL35 DNM2 FGFR3 SNAI2 NLRP1 ACTG2 GNB1 EWSR1 CBFB NSD1 FLCN ERBB2 MLH1 H19 EIF2AK4 RPL10 TMEM107 TRNK RAD54L RAD51C INPP5E NFKB1 CDKN1A KDM6B F13B SLC26A2 TRNS1 RPL26 CYLD H19 PTEN PTPN11 DCLRE1C MPL FLCN NEK1 MITF MSH3 NUTM1 IL7 STAT3 TRNS2 TG ERCC3 MNX1 NRAS MLH3 TSC1 GLI3 CDK4 SDHC NF1 BRCA2 CIB1 ATRX BRCA2 ADAMTS3 ZFPM2 COL2A1 TET2 ZIC2 SLCO2A1 BLM GJA1 MAP3K1 PIK3CA SDHA RTEL1 CDK4 KCNH1 SH2B3 APC ESCO2 FANCC TERT USP9X APC RAD54B NF2 SDHB RPS14 PPP2R1B RPS19 RPL35A MSH2 WRAP53 RASA1 LMNA ACVRL1 POLH SDHB DIS3L2 PIGA GNPTAB CXCR4 MSH2 SLC25A13 BMP2 NNT PSENEN FOXI1 APC IL1RN MITF ACD PTEN MPL RUNX1 ERCC3 ERCC4 DLEC1 CHEK2 BRCA2 JAK2 SBDS BRCA1 SDHD SEMA3D MSH6 HFE TREM2 APC CCDC22 MINPP1 DISP1 FAM20C MAP2K1 ALK BRCA1 STIM1 SLC25A13 RFWD3 HRAS GLI1 TET2 DVL3 COL7A1 HMBS TFAP2A ICOS CALR PTEN UROD DKC1 FDPS LIG4 TXNRD2 SRSF2 ND5 SDHD CHEK2 NRAS BCL6 GPC3 XPC MEN1 ERCC2 AXIN2 MYC RAD51 GBA KIF1B SDHB EXT2 EXT2 NTHL1 SRY RPGRIP1L MPL MTOR CASP8 RB1CC1 IGF2 FANCC ERCC4 WRN PGM3 VHL ING1 PLAG1 WT1 MYLK KLLN PIK3CA G6PC RPS7 MCM4 ANTXR1 POLH BRCA2 DLL1 OGG1 WRN F13A1 SBDS EFL1 TAF15 GLI3 GPC3 KRAS CDKN2B MAPK1 DIS3L2 GPR101 NRTN DKC1 KLLN NSUN2 MAP3K1 ERBB2 PHKG2 SRGAP1 CYLD NBN ALK MAX WT1 ACTB PALB2 TBX18 FIBP CASP10 DVL1 TYR MSH2 RECQL4 PIGL EDN3 WT1 ATP7B RPL27 RET USP8 FGFR2 PDGFRL H19 CCND1 ATM AXIN2 COL7A1 AKT1 TERT MUTYH HOXD13 DICER1 THPO GDF5 CEL SDHB EXT2 SRP72 TERT TRNF TP53 LIN28B APC NPM1 FGFR3 PTEN SMPD1 SLC22A18 SDHC PRDM16 KIT STK11 RPL11 LETM1 CALR SDHC RB1 PIK3CA PLCB4 COL4A5 CASP8 SKI H19 COL1A1 CC2D2A CASP10 GCGR GLI3 PIK3CA RPS29 RSPO1 PTEN MYSM1 BAP1 SRY UBE2T BRCA1 USP8 COL7A1 RNASEH2B KIF1B MN1 RELA SMAD4 VHL SH3KBP1 BCR CD79B SRP54 SRP54 SSX2 CHRNG RPL18 NF1 WWOX RERE LZTS1 WT1 MSH3 TYROBP ASCL1 IKBKG ABCC6 FAH KIT GDNF FANCE TERT BIN1 FANCL KIF11 SDHB WDPCP SLC6A17 TP53 HNF1A KEAP1 POLE HSPA9 SMO PTCH2 PTCH1 PMS1 ELMO2 BCL2 NSD2 EXT1 SRD5A3 STAT6 MVD TERC SF3B1 MNX1 FGFR1 CYSLTR2 POU2AF1 SMARCB1 NOD2 GJB2 SDHC FLT4 KRT9 CDH1 IRF1 SEC23B MYCN MGMT RPL10 RPL5 KIF7 TCF3 KRAS MUTYH TMEM127 KRAS IGH CTSC GNAS CD28 WWOX HNF1A BUB1B MC1R WNT10A CBL WT1 BRAF ADAR GAS1 GTF2E2 SMARCB1 RPS17 PARN TMEM127 BRIP1 SHH SRC GNAI3 STAR GDNF SLC22A18 FOXH1 SNAI2 GPC4 TNFRSF13C KARS1 TBC1D24 BMPR1A TET2 CD27 CASP8 DHCR7 KDSR HNF1A SH3GL1 PNP USB1 TSC2 TRIP13 TMEM67 EDN3 PMS1 PTPN11 GNA11 CREB1 ADA RAG2 PRSS1 KCNQ1 GPR101 PRF1 MTAP FANCA MSH6 TRNQ BRCA2 KRT1 RNASEL POU6F2 ACD SCN9A APC NSD2 INTU BRAF POU6F2 BRCA2 RB1 GTF2H5 PIK3CA FANCM TARS1 BRAF CASR RET VHL GPR143 TRNP GCM2 TMEM231 CPLANE1 RPS15A SOX9 GFI1B EPCAM MEN1 TERT KRAS SDHAF2 NF1 TRIP13 GATA2 SLC26A4 APC MPLKIP SAMD9L IL6 GNAS IGH AKT1 FANCD2 ESR1 SDHA APC MYF6 RASGRP1 SMAD4 MLLT10 LIG4 CPLANE1 BRCA2 MC1R MRE11 DLST SUFU LMO1 SDHB ABCA5 RMRP SDHC NUP214 AKT1 SMARCD2 DLC1 C1S TRNW THPO CHEK2 KIT SLC37A4 BCHE KCNJ11 ARID1B APC2 SAMD9 TMC6 SLX4 TNFRSF13B FGFR1 TRNH RAD21 KCNN3 DKC1 VANGL1 AXIN2 TCOF1 RPS19 SLC26A2 GPR35 CR2 TFAP2A KRAS FGFR3 PRKCD JAK2 EGFR AIP CTNNB1 KCNJ10 FANCI LYST TET2 SLC25A11 TP53 TCTN3 MUTYH ANTXR2 SEMA3C MMP1 AKT1 PDX1 JAK2 TCIRG1 PTCH1 MUC5B EXT1 DNMT3A BMPR1A SERPINA1 FAN1 CDC73 PTCH2 PIK3CA H19 FERMT1 GPC3 RET RET APC PALLD LPP BRD4 GNAS BMPR1B MAPRE2 DICER1 CTC1 TAL1 DICER1 STK11 HRAS GATA1 BCL10 KCNE3 XRCC4 HNF4A BDNF KLF11 SF3B1 MLH3 GNAQ TRPV3 IGLL1 PAX7 CRKL GDNF GATA2 ARL6IP6 ENG PTCH1 NEK9 TSC1 RNF139 ERCC3 PDGFRA IL2RG CTHRC1 WT1 BAP1 ATP7A SRP54 ABCC8 ESCO2 GPC4 OFD1 TNFSF15 APPL1 RNF6 CTSA TNFRSF1B TP53 PHOX2B DCLRE1C DDB2 BCL10 BCR KRT14 ALX3 EVC2 CD70 SMARCB1 AHCY SDHAF2 RAD51D SPINK1 SDHD ATM GABRD WT1 FASLG CTBP1 NOTCH1 NF2 DPM1 ERCC6 STS PHOX2B BUB1 FLT4 L2HGDH LAMC2 NTHL1 STAG3 ENG SDHD CTNNB1 DAXX NRAS MST1 MSTO1 SLC26A4 RAF1 STS FGFR3 EXOC6B VAMP7 NELFA HRAS ANTXR2 LEMD3 TNFSF12 GPC4 MLH1 SMAD4 RAD50 SUFU TRIP13 REST GNAS CBL RHBDF2 ASXL1 SMAD4 TCF4 ERCC6 WT1 BRAF APC TRIM28 TERT DNAJC21 RPL15 PAX3 SETBP1 CDH1 GNAS SMARCB1 AKT1 ASCL1 KRAS NAB2 ERCC5 RECQL4 KRAS DNMT3A EDN3 POLD1 FAM149B1 CDKN1C KRAS TP53 SMARCE1 PTEN PALB2 SEMA4A TEK NBN NHP2 GPC3 ETV6 FGF8 COL11A2 SMAD4 RNASEH2A NRAS MC1R TDGF1 FGFRL1 FGFR1 CTNNB1 IGH DNAJC21 CCND1 RET DIS3L2 DHCR24 CARD14 BRCA2 SQSTM1 NFKB2 TRNQ NDP SFTPA2 PAX4 COL7A1 TP53 RSPRY1 IFNG HMMR PALB2 FAT4 MBTPS2 MDM2 KRAS GNAS C2CD3 POT1 ABL1 WNT5A FANCE ABL1 ICOS SDHD RAD21 NSD1 SOS1 IL12A LIG4 PIK3CA TBXT RAD51 EWSR1 FZD2 FLNA BRCA2 NRAS TWIST1 TET2 TSC1 INHBA CAT CTNNB1 PIGL IRF1 PTCH2 TRNH MLH1 GFI1 CDC73 RET FANCD2 EVC NF2 TNPO3 SOX2 DYNC2H1 HRAS NEK1 CCND1 KRT10 AKT1 KIT PALB2 VHL CYLD IL1B GJC2 MLH1 SDHC FGFR2 CYP2A6 FOXE1 ARMC5 ERCC2 SLC25A11 LAMA3 FLCN BRCA1 BIRC3 MVK TOP2A PDGFB TCF4 RFWD3 ATP6V1B2 GDNF GATA4 CTNNB1 CDKN1B C2CD3 BRCA2 FUZ STK11 AKT1 FGFR2 SHOX TGFBR1 BTK LEMD3 FIBP SF3B1 SUFU PRLR NR5A1 FN1 ERBB2 CD19 RNR1 PTPN11 KIT RAD51 WAS PTEN TGFBR2 RPS24 CYLD RNF113A MYO1H ALX3 JAK2 BLM CTNNB1 CDKN2A PARN SH2B3 POLD1 CHEK2 COX1 KRT1 EXT1 BRAF PRCC MSH2 GATA2 REST NRAS RB1 TINF2 BMPR1A NR4A3 AGGF1 SIX3 RAG1 ND4 COL2A1 CDKN2A SDHD TREX1 WNT10A SEC23B XPA MET TP53 CDKN1B RPS27 PCNA HMBS RPS26 KIT FGFR2 TRIM37 HPGD ERCC5 PAX6 SLX4 PICALM PSAP FCN3 BMPR1A USF3 XPC DNAJC21 KRT16 BUB3 H19-ICR GPC6 STAC3 RPS28 FANCA RNF43 AP2S1 PDGFB DYNC2LI1 CYP11B1 ABCA5 PTCH1 TERF2IP KRAS DYNC2LI1 CDH1 CDC73 TERC SPRED1 PDGFB TRNF MTMR14 MAD2L2 FOXI1 ERCC2 GJB4 KAT6B MSH6 FASLG KRAS SEC23A RUNX1 CD19 WASHC5 KIT HLA-DRB1 WRAP53 FLT3 CEP57 KDR TREX1 TMEM216 PDGFRA ERCC3 KIT NOTCH3 WIPF1 TERC CTLA4 NQO2 CDKN2A RSPO1 STK4 PTPN11 GJB2 KRAS MET SPINK1 PDGFRB RHOH BUB1 ND6 CDKN2C TFE3 EP300 CHIC2 HNF1B NUMA1 BRCA1 SRY FLCN MLH3 SCN10A GNPTAB KRAS NODAL TGFBR2 PPM1D DOCK8 EPAS1 PHOX2B OCA2 KCNQ1OT1 CYP2D6 ITK DICER1 PRKCD ASPSCR1 SUFU IDH1 RUNX1 ATRX FOXC2 MFN2 SAMD9L SCN4A KIF1B DHH POLE VHL POLR1D KCNAB2 BRAF SLC12A3 CARMIL2 ENPP1 NRAS LRRC8A KIT SH2B3 MST1R CEBPA NRAS MRAP TP53 ND5 FH LAMB3 CALR SLC37A4 PERP KLHDC8B FH SFTPC TGIF1 CHEK2 SLC17A9 SLC22A18 TERT CDH23 MDH2 KRT17 PTEN FGFR3 RB1 YY1 ELANE EP300 SPRTN GJB3 XPA IDH2 MAGT1 ATR GNA14 OFD1 IL7R GREM1 ESCO2 HRAS PRKAR1A MMP1 TP53 KRT17 COL14A1 RHBDF2 MPL OFD1 RYR1 IFIH1 SCN11A IDH1 JAK2 WT1 TP53 ARSA LIG4 CCBE1 FANCG KCNH1 ELANE COL18A1 HACE1 NUP214 MYC CD79A AR CDH1 BRIP1 WT1 BCR BUB1B ERCC3 KRIT1 NBN IGF2 FANCF PDGFRA BLNK PCGF2 MSH6 MEN1 FAS BRIP1 PTH1R SIX1 RNF6 BRAF DHCR7 BMPER BUB1B TP53 RET CTLA4 HABP2 ARHGAP26 DLST GCK ERCC2 RAD54L POLE HSPG2 GNA11 ADA SMAD4 BCL10 RB1 STAT1 TAF1 RPS14 BCR IL12RB1 IRF5 TMC8 TNFRSF13B CYP26C1 CALR POT1 MINPP1 POLR1C CD28 ATP7A HNF1B ERCC2 ACVR1 RPL31 VANGL1 TP63 ERCC4 SLC45A2 OFD1 LMX1B PIK3CA ASCC1 TET2 IGF2R BARD1 TUBB IGF2 BTK MSTO1 CIB1 PHB CDKN2A TNFRSF10B KIAA0753 TBX2 FOXE1 EPCAM TNFRSF13C SLC26A2 ATRX MGAT2 SKIV2L CXCR4 PIK3R1 RTEL1 TSC1 HAX1 SDHB PRKAR1A DDB2 GFI1 CDH23 XRCC3 PMVK TP53 PIK3CA GJB2 NF2 KLF6 AR ZSWIM6 SDHB CDC73 PIK3CA CCND1 GJB6 ATM SOS1 NOTCH3 DDX41 TSC2 FLT4 FGFR3 RASA1 GDF2 F5 PMS2 PTEN HBB TSC2 CASP10 ADA2 AIP WT1 LETM1 PNP COMP TRIM28 TP53 PALB2 RAD51C CCL2 CDC73 SH2D1A COX3 ZAP70 PIK3CA CYP11B2 PDGFRB PTPN11 PHOX2B FH KIT HNF4A RNASEH2C MYD88 PDE6D JAG1 TYR SEC23A FH NPM1 PHKA2 DICER1 PIK3CA HFE GNAQ DMRT3 MS4A1 MYH8 VANGL2 SHOX PUF60 GATA2 BAP1 B3GALT6 TRNS2 HRAS HDAC4 FANCG SAMHD1 GATA2 LIG4 AXIN1 TNFRSF4 OPCML PRKN FGFR2 ECM1 TGFBR2 LMNA WDPCP KCNQ1OT1 BLK GCM2 ALX1 NRAS KIT AAGAB FAH MAX RARA NEUROD1 TGFBR2 MYD88 PHF21A IDH1 MLH1 FANCB CPLX1 SMARCA4 EXTL3 AIP TERT BCL10 XIAP IGF2 SASH1 PIK3R1 PTEN NAGS TMC6 NBEAL2 NOP10 JAK2 SDHB MSH2 ECE1 BARD1 APC PMS2 CCM2 JAK2 MMEL1 RET SDHA SDHD IGHM CACNA1S FAS NR0B1 POT1 SPIB TAL2 NF2 CDON WT1 TET2 PTPRJ CD96 TRNL1 DOCK8 DCC MPL GNAQ CREBBP CDKN2A TRNK MSR1 KRT5 PRKAR1A ERBB3