SNPMiner Trials by Shray Alag

SNPMiner SNPMiner Trials (Home Page)

Report for Clinical Trial NCT03701815

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Assessing the Effect of Multi-disciplinary Lifestyle Medicine Intervention on Brain-derived Neurotrophic Factor Levels Following Stroke

This is a pilot study to determine whether a lifestyle medicine intervention following stroke may increase levels of Brain-Derived Neurotrophic Factor (BDNF).

NCT03701815 Stroke

1 Interventions

Name: Wellness in Rehabilitation program

Description: The 12-week Wellness in Rehabilitation program includes weekly in-person meetings including aerobic exercise, nutrition/cooking training, stress management techniques, education, and group support. A health coach will facilitate continuation of healthy behaviors at home.
Type: Behavioral
Group Labels: 1


Primary Outcomes

Description: Plasma BDNF protein levels, expressed in nanograms per milliliter, measured prior to any exercise upon completion of intervention.

Measure: BDNF level - Final

Time: Week 12

Secondary Outcomes

Description: Plasma BDNF protein levels, expressed in nanograms per milliliter, measured immediately following bout of aerobic exercise.

Measure: BDNF level - Post-exercise

Time: Week 6

Description: Genotyping of venous blood samples to determine ValVal, MetMet, and ValMet distribution.

Measure: BDNF Genotype

Time: Baseline

Description: Measured as VO2 max (ml/kg/min).

Measure: Cardiovascular Fitness - VO2 max

Time: Week 12

Description: Measured as estimated metabolic equivalents (kcal/kg/hour).

Measure: Cardiovascular Fitness - METs

Time: Week 12

Description: Total distance walked 6 minutes on a flat surface.

Measure: 6-minute Walk Test

Time: Week 12

Purpose: Treatment

Allocation: N/A

Single Group Assignment

There is one SNP


1 V66M

An single nucleotide polymorphism exists on the BDNF gene in 30-50% of the human population that results in an amino acid change from valine (val) to methionine (met) at position 66 (val66met) of the precursor peptide proBDNF. --- val66met ---

HPO Nodes