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Report for Clinical Trial NCT01604681

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

The Effect of Flaxseed Oil Supplementation on Biomarkers, Quality of Life and Cognitive Function in Hypertensive and Dyslipidemic Subjects With or Without the C677T and A1298C Polymorphisms in MTHFR Gene in Different Municipalities of Rio de Janeiro

The purpose of this study is to evaluate the effect of supplementation with flaxseed oil combined with a nutritional counseling in reducing cardiovascular risk factors in homocysteine , biomarkers of inflammation, oxidative stress, improving quality of life and cognitive decline in hypertensive and dyslipidemic genotyped for the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene.

NCT01604681 Hypertension Dyslipidemia
MeSH:Dyslipidemias
HPO:Abnormal circulating lipid concentration

2 Interventions

Name: Placebo

Description: 6 capsules per day, thirty minutes before lunch and dinner, eating 3 capsules (3 g) at a time.
Type: Dietary Supplement
Group Labels: 1

placebo group

Name: Flaxseed Oil

Description: 6 capsules per day, thirty minutes before lunch and dinner, eating 3 capsules (3 g) at a time.
Type: Dietary Supplement
Group Labels: 1

Flaxseed oil group


Primary Outcomes

Description: To evaluate the effect of nutritional counseling associated with linseed oil supplementation on biomarkers estutados according to the C677T and A1298C polymorphisms of the MTHFR gene.

Measure: Polymorphisms

Time: Up to 3 months

Secondary Outcomes

Description: To evaluate the effect of nutritional counseling associated with linseed oil supplementation on cognitive decline.

Measure: Cognitive decline

Time: Up to 3 months

Description: To evaluate the effect of nutritional counseling associated with linseed oil supplementation on Quality of life.

Measure: Quality of life

Time: Up to 3 months

Description: To evaluate the effect of nutritional counseling associated with linseed oil supplementation on biomarkers of oxidative stress.

Measure: Oxidative stress

Time: Up to 3 months

Description: To investigate the effect of supplementation of flaxseed oil combined with nutritional guidance on lipid profile, according to the consumption of saturated fat.

Measure: Lipid profile

Time: Up to 3 months

Allocation: Randomized

Parallel Assignment


There are 2 SNPs

SNPs


1 A1298C

The Effect of Flaxseed Oil Supplementation on Biomarkers, Quality of Life and Cognitive Function in Hypertensive and Dyslipidemic Subjects With or Without the C677T and A1298C Polymorphisms in MTHFR Gene in Different Municipalities of Rio de Janeiro. --- C677T --- --- A1298C ---

Supplementation With Flaxseed Oil in the State of Rio de Janeiro The purpose of this study is to evaluate the effect of supplementation with flaxseed oil combined with a nutritional counseling in reducing cardiovascular risk factors in homocysteine , biomarkers of inflammation, oxidative stress, improving quality of life and cognitive decline in hypertensive and dyslipidemic genotyped for the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene. --- C677T --- --- A1298C ---

To evaluate the effect of nutritional counseling associated with linseed oil supplementation on biomarkers estutados according to the C677T and A1298C polymorphisms of the MTHFR gene.. Cognitive decline. --- C677T --- --- A1298C ---

Our goal is to evaluate the effect of supplementation with flaxseed oil combined with nutritional counseling in reducing cardiovascular risk factors in homocysteine, biomarkers of inflammation, oxidative stress, improving quality of life and cognitive decline in hypertensive individuals dyslipidemic and genotyped for polymorphisms C677T and A1298C methylenetetrahydrofolate reductase gene (MTFHR). --- C677T --- --- A1298C ---

Will be collecting information on the socio-economic status of study participants through a structured questionnaire will be carried out assessment of food consumption - frequency of consumption and 24 hours, clinic - blood pressure, anthropometric - height, weight, waist circumference and BMI, body composition - bioelectrical impedance analysis, biochemical tests - lipid profile, blood glucose, insulin, homocysteine, serum folate concentrations in erythrocytes and, cobalamin, vitamin C, E and A, minerals - zinc, iron, copper and selenium, markers of oxidative stress and inflammatory response and molecular analysis - C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene. --- C677T --- --- A1298C ---

Our results demonstrate the effectiveness of supplementation with flaxseed oil, in reinforcing the results of nutritional counseling in reducing cardiovascular risk factors and biomarkers studied, besides adding to the knowledge about the interactions between markers of inflammation, oxidative stress with oil supplementation flaxseed and polymorphisms C677T and A1298C MTHFR gene, on which there are no reports in the literature. --- C677T --- --- A1298C ---


2 C677T

The Effect of Flaxseed Oil Supplementation on Biomarkers, Quality of Life and Cognitive Function in Hypertensive and Dyslipidemic Subjects With or Without the C677T and A1298C Polymorphisms in MTHFR Gene in Different Municipalities of Rio de Janeiro. --- C677T ---

Supplementation With Flaxseed Oil in the State of Rio de Janeiro The purpose of this study is to evaluate the effect of supplementation with flaxseed oil combined with a nutritional counseling in reducing cardiovascular risk factors in homocysteine , biomarkers of inflammation, oxidative stress, improving quality of life and cognitive decline in hypertensive and dyslipidemic genotyped for the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene. --- C677T ---

To evaluate the effect of nutritional counseling associated with linseed oil supplementation on biomarkers estutados according to the C677T and A1298C polymorphisms of the MTHFR gene.. Cognitive decline. --- C677T ---

Our goal is to evaluate the effect of supplementation with flaxseed oil combined with nutritional counseling in reducing cardiovascular risk factors in homocysteine, biomarkers of inflammation, oxidative stress, improving quality of life and cognitive decline in hypertensive individuals dyslipidemic and genotyped for polymorphisms C677T and A1298C methylenetetrahydrofolate reductase gene (MTFHR). --- C677T ---

Will be collecting information on the socio-economic status of study participants through a structured questionnaire will be carried out assessment of food consumption - frequency of consumption and 24 hours, clinic - blood pressure, anthropometric - height, weight, waist circumference and BMI, body composition - bioelectrical impedance analysis, biochemical tests - lipid profile, blood glucose, insulin, homocysteine, serum folate concentrations in erythrocytes and, cobalamin, vitamin C, E and A, minerals - zinc, iron, copper and selenium, markers of oxidative stress and inflammatory response and molecular analysis - C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene. --- C677T ---

Our results demonstrate the effectiveness of supplementation with flaxseed oil, in reinforcing the results of nutritional counseling in reducing cardiovascular risk factors and biomarkers studied, besides adding to the knowledge about the interactions between markers of inflammation, oxidative stress with oil supplementation flaxseed and polymorphisms C677T and A1298C MTHFR gene, on which there are no reports in the literature. --- C677T ---



HPO Nodes


HPO:
HP:0003119: Abnormal circulating lipid concentration
Genes 290
DCAF17 APOA2 PEX5 LMNA POLR3A PNPLA2 PRF1 PHYH APOB PMM2 TNFSF15 TDP1 SMPD1 PEX1 CPT2 PEX6 PIGT LMNA BSCL2 SPINK1 CYP19A1 XRCC4 ABCC8 HSD3B7 ABCG8 ACADVL LDLR AGPAT2 ADCY3 TTPA CETP LIMK1 OCRL TBL2 PEX2 BSCL2 UCP2 GK SLC29A3 SLC37A4 NADK2 ZMPSTE24 MCFD2 LTC4S CETP PEX10 MYO5A TRNL1 PSMB8 LMNA GPIHBP1 LMNB2 DGAT1 SLC12A1 TFG SC5D PEX19 PEX10 LCAT ACAD9 ACAD8 AR LMNA PEX2 MEF2A CTRC PEX7 RAI1 PIK3R5 CEP19 EBP PYGL ACADL BSCL2 POU2AF1 LIPE CFH APOB CLIP2 ACADM PEX5 FHL1 AEBP1 CAVIN1 ANGPTL3 PSMB9 HMGCL DHCR24 FOS FECH TMEM199 GHR PLVAP CYP11A1 LMNA DHCR7 XRCC4 SMPD1 SGPL1 EBP CCT5 PIGH MC4R APOA5 IL12RB1 IRF5 CAV1 STX11 DHCR7 ACAD8 IL12A TRNK AGL POLD1 SLC25A20 PPP1R17 ALMS1 ABHD5 UBE3B LRP6 APOA5 PRSS1 ABCA1 DYRK1B CCDC115 NGLY1 SYNE1 RAI1 LIPA APOA1 ALB FLII PEX7 LDLRAP1 SYNE2 TNPO3 LEPR MSMO1 TMEM43 LCAT FBN1 LDLR GLA SAR1B OCRL ABCG8 KCNJ11 TRMU ABCA1 LEP CAV1 NPC2 HAVCR2 BSCL2 LMNA COG4 ABCD1 IQSEC2 SLC25A13 LMNA GHR LPL UBR1 PEX13 PHKG2 SAR1B PEX11B APTX SLC25A13 CIDEC TBCK ALMS1 XIAP PPARG KCNJ1 PNPLA2 NPHS1 DLD AGL AKT2 GTF2I PEX1 ABCA1 POLR3A NPC1 CTNS SLC37A4 LIPC LMNA SLC25A13 JAG1 ZMPSTE24 LIPA PSMB4 MTTP PHKA2 NUP107 SLC7A7 LIPE ACTN4 CFHR1 APOE ABCA1 PEX14 TRNE APOC3 ACADVL EMD LPL APOC2 NUP107 HMBS CAV1 LDLRAP1 RAI1 LMNA ELN LMAN1 PEX26 ALB PEX19 RAB27A CYP27A1 CFHR3 LMNA TANGO2 ACOX2 FLCN CAVIN1 EPHX2 PPARG CYP7A1 PLIN1 BAZ1B SLC52A1 DEAF1 PEX5 GYS2 SLC22A5 HADH CPT1A NSDHL G6PC PCSK9 ZMPSTE24 PPARG APOC3 HNF1A TRNE NSMCE2 GPD1 CAV3 PANK2 RFC2 HNF4A UNC13D SLC25A13 MMEL1 NPHS2 PEX12 PEX16 PHKA2 PHKG2 TDP1 RSPO1 LMNA PLA2G4A ACADM PCSK9 DCAF17 APOB STXBP2 CIDEC PLA2G7 LBR SPIB NADK2 TANGO2 CYP11A1 PLIN1 PNLIP LCAT CPT1A ABCG5 PEX3 GTF2IRD1 PEX12 AGPAT2 CYP27A1 SETX