The aim of the study is to evaluate the pharmacodynamic impact of metformin in healthy Caucasian volunteers with and without single polymorphisms M420del or R61C in OCT1, thus the study hypothesis is that metformin only affect the hepatic gluconeogenesis in healthy volunteers with functional OCT1-transporters.
Name: Metformin
Allocation: Randomized
Parallel Assignment
There is one SNP
The Inhibitory Effect of Metformin on Gluconeogenesis in Relation to Polymorphisms in Organic Cation Transporter 1 The aim of the study is to evaluate the pharmacodynamic impact of metformin in healthy Caucasian volunteers with and without single polymorphisms M420del or R61C in OCT1, thus the study hypothesis is that metformin only affect the hepatic gluconeogenesis in healthy volunteers with functional OCT1-transporters. --- R61C ---
Inclusion Criteria: - Healthy volunteers - Written consent - Genotyped in OCT1 for (M420del and R61C) Exclusion Criteria: - Daily medication - Alcohol abuse - Pregnancy - Breastfeeding Inclusion Criteria: - Healthy volunteers - Written consent - Genotyped in OCT1 for (M420del and R61C) Exclusion Criteria: - Daily medication - Alcohol abuse - Pregnancy - Breastfeeding Pharmacogenetics of Metformin null --- R61C ---
Inclusion Criteria: - Healthy volunteers - Written consent - Genotyped in OCT1 for (M420del and R61C) Exclusion Criteria: - Daily medication - Alcohol abuse - Pregnancy - Breastfeeding Inclusion Criteria: - Healthy volunteers - Written consent - Genotyped in OCT1 for (M420del and R61C) Exclusion Criteria: - Daily medication - Alcohol abuse - Pregnancy - Breastfeeding Pharmacogenetics of Metformin null --- R61C --- --- R61C ---