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Report for Clinical Trial NCT00320879

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Optimal Dose of Irbesartan for Renoprotection in Type 2 Diabetic Patients With Persistent Microalbuminuria

Aim: To evaluate the renoprotective effect as reflected by short-term changes in albuminuria of ultra high doses of irbesartan in Type 2 diabetic patients with microalbuminuria Design: A double-masked randomized cross-over trial including 60 hypertensive Type 2 diabetic patients with microalbuminuria on ongoing antihypertensive medication. At inclusion, previous antihypertensive treatment will be discontinued and replaced with bendroflumethiazide 5 mg o.d. for the entire study. Following two months wash-out (baseline), patients will be treated randomly with irbesartan 300, 600 and 900 mg o.d., each dose for two months. End-points evaluated at the end of each study period include urinary albumin excretion rate (UAE, mean of three 24-hrs collections), 24-hrs blood pressure (ABP); and GFR (51Cr-EDTA).

NCT00320879 Type 2 Diabetes Microalbuminuria
MeSH:Albuminuria
HPO:Albuminuria

1 Interventions

Name: irbesartan

Type: Drug


Primary Outcomes

Measure: urinary albumin excretion rate

Secondary Outcomes

Measure: ambulatory blood pressure

Measure: glomerular filtration rate

Measure: serum potassium

Measure: serum creatinine

Measure: lipids

Measure: renin

Measure: aldosterone

Measure: NT-proBNP

Measure: markers of endothelial function

Measure: markers of inflammation

Measure: genotypes with possible implications for the risk of cardiovascular disease

Purpose: Treatment

Allocation: Randomized

Crossover Assignment


There are 2 SNPs

SNPs


1 A1166C

Initially we will evaluate the influence of the ACE/ID- , Angiotensin II type I receptor (A1166C) - and the angiotensinogen (M235T) polymorphisms. --- A1166C ---


2 M235T

Initially we will evaluate the influence of the ACE/ID- , Angiotensin II type I receptor (A1166C) - and the angiotensinogen (M235T) polymorphisms. --- A1166C --- --- M235T ---



HPO Nodes


HPO: