SNPMiner Trials by Shray Alag

SNPMiner SNPMiner Trials (Home Page)

Report for Clinical Trial NCT03107156

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Understanding Evidence-Based Practice Patterns in Advanced NSCLC: An Educational/Research Initiative in Mid-Atlantic States

The overarching objective of this study is to close clinical knowledge and performance gaps by providing oncology clinicians with the latest advances and emerging research in the evidence-base and personalized treatment of advanced NSCLC patients. In addition, the research team seeks to meet quality measures relevant to value-based care delivery through IT infrastructure and clinical workflow processes. The research team also hopes to gain insights on clinician practice patterns related to advanced NSCLC, and the correlation between advanced NSCLC patients reported goals of care and advanced NSCLC patients' fit/frailty status and treatment decisions.

NCT03107156 Non Small Cell Lung Cancer
MeSH:Carcinoma, Non-Small-Cell Lung
HPO:Non-small cell lung carcinoma

1 Interventions

Name: Carevive CPS

Description: This intervention will focus on the use of the Carevive CPS at the point of treatment decision making, enabling providers to deliver evidence-based and personalized treatment care plans to their NSCLC patients on active treatment. The Carevive CPS collects electronic patient reported outcomes (ePROS) and clinical data, reported and generated by clinical staff and/or extracted from the electronic medical record (EMR), and uses these to auto-generate the personalized care plans. Care plan content is drive by practice guidelines and other peer-reviewed evidence, and includes patient education, resources, and referrals developed by cancer clinicians and researchers.
Type: Behavioral

Primary Outcomes

Description: Data collected on the Carevive CPS will be analyzed in order to correlate the patient biomarker testing results with treatment selections.

Measure: Adherence (by providers) to evidence-based treatment recommendations for patients with advanced NSCLC

Time: Year 1

Secondary Outcomes

Description: An in-person workshop will be held at which clinicians treating patients with NSCLC will gather in discussion regarding what value-based care is and how it affects their patients.

Measure: Components of value-based NSCLC cancer care.

Time: Year 1

Description: Clinician practice patterns of medical oncologists managing older patients with advanced NSCLC, including sub-analyses of practice patterns for those who are considered "fit", "intermediate fit", and "frail," will occur.

Measure: Clinical practice patterns in medical oncologists managing older patients with advanced NSCLC.

Time: Year 1

Other Outcomes

Description: To explore how frequently older adults with lung cancer are hospitalized or visit the ER as a result of their lung cancer.

Measure: ER utilization and hospitalization in elderly patients with lung cancer

Time: Year 1

Purpose: Supportive Care

Allocation: N/A

Single Group Assignment

There is one SNP


1 L858R

For example, the NCCN notes that there is a significant association between EGFR mutations—especially exon 19 deletion and exon 21 (L858R, L861) and exon 18 (G719X, G719) mutations—and sensitivity to TKIs, and that the exon 20 insertion mutation may predict resistance to clinically achievable levels of TKIs. --- L858R ---

HPO Nodes